DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul3 and Cul4a

DIOPT Version :9

Sequence 1:	NP_723909.2	Gene:	Cul3 / 34896	FlyBaseID:	FBgn0261268	Length:	934	Species:	Drosophila melanogaster
Sequence 2:	NP_666319.2	Gene:	Cul4a / 99375	MGIID:	1914487	Length:	759	Species:	Mus musculus

Alignment Length:	805	Identity:	291/805 - (36%)
Similarity:	443/805 - (55%)	Gaps:	74/805 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 TETSATTSGPST--SASASAESTEKRFKEIARKYPLWLPEYKRRAFNASMDEKYVETIWASLKNA 199
            |:.:|...||:.  ....|.:...|.|::..|     ||            :.|.:..|..|..|
Mouse    22 TKPAALAGGPAKPGGTGGSRKLVIKNFRDRPR-----LP------------DNYTQDTWRKLHEA 69

  Fly   200 IQEIQKKNNSGLSFEQLYRNAYNMVLHKHGNRLYYGLREVVSEHLEHKV---RADVLEALHSNFL 261
            ::.||...:...:.|:||:...|:..||....||..||:|..:|::.::   |.|.|:::  .||
Mouse    70 VKAIQSSTSIRYNLEELYQAVENLCSHKVSPTLYKQLRQVCEDHVQAQILPFREDSLDSV--LFL 132

  Fly   262 PKLNQAWTDHQTSMVMIRDILMYMDRVYVQQRE-VDNVYNLGLILFRDQVVRYSEIQKALREKLL 325
            .|:|..|.||...|:|||.|.:::||.||.|.. :.:::::||.|||:.::....:|....:.:|
Mouse   133 KKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRNHIISDRMVQSKTIDGIL 197

  Fly   326 GMVMEERHGEAINHLAIKNACSMLITLGINSRTVYEEDFEKPFLAQSAAFYKFESQNFLAENNAG 390
            .::..||.|||::...:::..|||..|     .||::.||..||.::...|..|.|..:.:....
Mouse   198 LLIGRERSGEAVDRSLLRSLLSMLSDL-----QVYKDSFELKFLEETNCLYAAEGQRLMQDREVP 257

  Fly   391 VYIKKVEARITEESSRAALYLDKDTEPRIVRVVEEELIKKHMRPIVEMENSGVVYMIKNSKTEDL 455
            .|:..|..|:.||:.|...|||..|:..::..||::|:.:|:..|::   .|:.:::..::..||
Mouse   258 EYLNHVSKRLEEEADRVITYLDHSTQKPLIACVEKQLLGEHLTAILQ---KGLEHLLDENRVPDL 319

  Fly   456 ACTYKLFSRLKEEGLKVIADTMSAYLREQGRMLVKEEENGNTNPITFVQNLLDLKDRFDQFLVHS 520
            ...|:||||:| .|...:....|.|::..|..:|...|...    ..||:|||.||:.|..:...
Mouse   320 TQMYQLFSRVK-GGQHALLQHWSEYIKTFGTTIVINPEKDK----DMVQDLLDFKDKVDHVVEVC 379

  Fly   521 FANDRIFKNVISSDFEHFLNLN-NKSPEYLSLFIDDKLKKGGKGMSEQEIESILDKTMVLFRFLL 584
            |..:..|.|::...||.|:|.. ||..|.::..:|.||:.|.|..:::|:|.||||.|:||||:.
Mouse   380 FQRNERFINLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERILDKIMILFRFIH 444

  Fly   585 EKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSVSNTIMDEFK 649
            .|||||.:||..||||||:.||.|.|.||:|:||||.|||..||||||||||||.:|..||..||
Mouse   445 GKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFK 509

  Fly   650 NFVNNNNLSLGGVELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFKNFYLNKHSGRQLTLQPQ 714
            ..:.|.: :.|.::|||.|||.|:|||.|.. ..::|.......::||.|||.|||||:|..|..
Mouse   510 QHMQNQS-APGPIDLTVNILTMGYWPTYTPM-EVHLPPEMVRLQEVFKTFYLGKHSGRKLQWQTT 572

  Fly   715 MGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTYQMCVLLLFNNRDVLTYD 779
            :|.|.:.|.|     .|.:|:                     .|||.:|..|||:||..|..:::
Mouse   573 LGHAVLKADF-----KEGKKE---------------------FQVSLFQTLVLLMFNEGDGFSFE 611

  Fly   780 DIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVNDAFNSKFHRVKIQTV 844
            :|...|.|.:.||.|.||||:.||  .|:|:::  .|.|::|..|:|..|..|..|..|:||..:
Mouse   612 EIKMATGIEDSELRRTLQSLACGK--ARVLIKS--PKGKEVEDGDKFIFNADFKHKLFRIKINQI 672

  Fly   845 AAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVFIKK 909
            ..| |:..|:..|..:|.:||:::|:||||||||.||.|.||||||::.:|||  |...|..:||
Mouse   673 QMK-ETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLK--FPVKPGDLKK 734

  Fly   910 RIEGLIEREYLQRSPEDRKVYNYLA 934
            |||.||:|:|::|..:....|:|:|
Mouse   735 RIESLIDRDYMERDKDSPNQYHYVA 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	196..831	CDD:279260	231/639 (36%)
		CULLIN	582..724	CDD:214545	74/141 (52%)
		Cullin_Nedd8	866..926	CDD:287520	33/59 (56%)
Cul4a	NP_666319.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		4/17 (24%)
		Cullin	65..659	CDD:279260	231/640 (36%)
		CULLIN	442..582	CDD:214545	74/141 (52%)
		Cullin_Nedd8	688..753	CDD:214883	36/66 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0000491
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.830