Protein Alignment Cul3 and RTT101

DIOPT Version :9

• Sequence 1: NP_723909.2
• Gene: Cul3 / 34896
• FlyBaseID: FBgn0261268
• Length: 934
• Species: Drosophila melanogaster
• Sequence 2: NP_012488.3
• Gene: RTT101 / 853400
• SGDID: S000003583
• Length: 842
• Species: Saccharomyces cerevisiae
• Alignment Length: 921
• Identity: 179/921 - (19%)
• Similarity: 308/921 - (33%)
• Gaps: 268/921 - (29%)

  Fly   148 TSASASAESTEKRF---KEIARKYPLWLPEYKRRAFNASMDEKYVETIWASLKNAIQEIQKKNNS 209
            |.|....|:..|..   ||.|.|:...:|:........:..:.|:.  :.|..|...|.|||
Yeast    54 TLAETITETDVKELECNKEKAAKFRKLMPKMLNNCRELTQRKSYIP--YNSEFNGNDEKQKK--- 113

  Fly   210 GLSFEQLYRNAYNMVLHKHGNRLYYGLREVVSEHLEHKVRADVLEAL-----HSNFLPKLNQAWT 269
               |:         :||:|  ::....:|...|..:..:.|.||..|     ....:||   .||
Yeast   114 ---FQ---------LLHQH--QIVLSFQEFCDELAKLIIDAHVLSFLTRCDYSYEIIPK---NWT 161

  Fly   270 D----HQTSMVMIRDILMYMDRVYVQQREVDNVYNLG---LILFRDQVVRYSEIQKALREKLLGM 327
            .    .|..|..:..|:.|:...|...|:     .||   |.:|:....:..|..|:...:....
Yeast   162 SFYKLFQYVMGAVGPIISYVPVNYPMIRK-----ELGFETLTIFQYYDSKLFECMKSHFGREFST 221

  Fly   328 VMEERHGEAINHLAIKNACSMLITLGINSRTVYEEDFEKPFLAQSAAFYKFESQNFLAE--NNAG 390
            ::.......|:...|.|             |:.|:  |.|.|.      ...:.||..|  :...
Yeast   222 LVSATIHHYIHMFPITN-------------TMLEK--EVPMLR------IMSNCNFSIEGLSPKD 265

  Fly   391 VYIKKVEARITEESSRAALYLDKDTEPRIVRVVEEELIKKHMRPIVEMENSGVVYMIKN------ 449
            .|:|.:.....|||                          ::||.:|...:..|.:.:|
Yeast   266 FYMKTLRQYYCEES--------------------------NLRPRLETFKNFKVLLTRNALLASL 304

  Fly   450 ------SKTEDLACTYKLFSRLK-EEGLKVIADTMSAYLREQGRMLVKEEENGNTNPITFVQNLL 507
                  |...||..::.|.::.. .|.:::..||   |..|:.|....|....    :...:|..
Yeast   305 FSPEWVSDANDLFISHLLLNKKSISEYIEIGKDT---YDEEKERYFKTETHFS----LLMFRNAF 362

  Fly   508 DLKDRFDQFLVHSFAND-----------------RIFKNVI-----------SSDFE-HFLNL-- 541
            :.|:...:|  ..|.:|                 |:|..|:           |...| |..||
Yeast   363 EAKNMLSKF--KEFCDDAVSEKLKAAYGSNHDTERLFDEVVQLANVDHLKIYSDSIEYHLCNLLG 425

  Fly   542 -NNKSPE-YLSLF------IDDKLKKGGKGMSEQEIESILDKTMVLFRF-LLEKDVFERYYKTHL 597
             .:|:.| |:..|      |..|:|...|.:........|::.:.:.|. .:....|..:::..:
Yeast   426 STSKAIEQYVKYFESHLFIIVRKIKTTKKDLPRDMKIKYLNENLPILRLKFVNLPTFPNFFERSI 490

  Fly   598 AKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSVSNTIMDE--------------- 647
            .::.:|....:..|.|:::...|        ..|..:||...::|...::
Yeast   491 FRKTILQSDQNSSFIKDILPVYK--------DSLMELFKQRIITNVSQEDEMRYRDQYQPYLSQF 547

  Fly   648 ----------------FKNFVNNNNLSLGGVELTVRILTT-------GFWPTQTATPNCNIPAAP 689
                            |.:|..|       :|..|:...|       .|:|  .......||...
Yeast   548 FQPVEVMADLRIKYASFLSFYEN-------IEAAVKFGKTYNENNSKSFFP--LIFDRERIPKVF 603

  Fly   690 REAFDIFKNFYLNKHSGRQLTLQPQMGTAYINAVFYGRKAVESEKDKDA------PSSSSSGCGV 748
            :::.::.|||.|           ||......|............:|.||      |..:...|.|
Yeast   604 QQSNEVKKNFVL-----------PQEMDDTWNQFLRNYHEQNKVEDSDASKKELYPMWNLHHCEV 657

  Fly   749 PTTTRKHILQVST--------YQMCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPA 805
            .:   .:|:|..|        :|.|||.|||..|.||...|.::|.:..::|...|:|..
Yeast   658 ES---PYIIQDGTNLIFELTLFQTCVLTLFNESDHLTLQVISEQTKLAYKDLALVLKSFC----- 714

  Fly   806 QRLLVRNSKTKTKDIEPTDEFYVNDAFNSKFHRV---KIQTVAAKGESEPERKETRGKVDEDRKH 867
                  |.|..|:||:.|  :.:|::|.....:|   |::.|..:..| .:...|.|:......|
Yeast   715 ------NYKILTRDIDNT--YSINESFKPDMKKVKNGKLRVVLPRTAS-LQSSNTGGERTSSAHH 770

  Fly   868 E----------IEAAIVRIMKA-RKRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQ 921
            |          ::|.|.|.:|: |..|.::.|...|..|:|...:..   .|..:..|:..:::.
Yeast   771 EGSNSQWTQELLKACITRSVKSERNGLDYDHLFETVKQQIKGFSVGE---FKDALAKLLRDKFIT 832

  Fly   922 RSPEDRKVYNY 932
            |. |....|.|
Yeast   833 RD-ESTATYKY 842

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	196..831	CDD:279260	143/753 (19%)
		CULLIN	582..724	CDD:214545	26/180 (14%)
		Cullin_Nedd8	866..926	CDD:287520	15/70 (21%)
RTT101	NP_012488.3	COG5647	<519..842	CDD:227934	75/363 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900