DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul3 and CUL3

DIOPT Version :9

Sequence 1:	NP_723909.2	Gene:	Cul3 / 34896	FlyBaseID:	FBgn0261268	Length:	934	Species:	Drosophila melanogaster
Sequence 2:	NP_011517.1	Gene:	CUL3 / 852886	SGDID:	S000003235	Length:	744	Species:	Saccharomyces cerevisiae

Alignment Length:	812	Identity:	216/812 - (26%)
Similarity:	368/812 - (45%)	Gaps:	115/812 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 RKYPLWLPEYKRRAFNASMDEKYVETIWASLKNAIQEIQKKNNSGLSFEQLYRNAYNMVLHKHGN 230
            :|..:.:||      ...:.|:..|..|.::|.||..|...:.:.|||||:|:..|.:||:|.|.
Yeast     5 KKIKISVPE------KLGLSEESFEESWETVKYAIDHIYSDDMADLSFEQVYKTIYTIVLNKKGP 63

  Fly   231 RLYYGLREVVSEHLEHKVRADVLEALHS-NFLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQQRE 294
            .||..|::.:.:.|.......|.:..|. .||..:.:.|........:..|::||||:||.:...
Yeast    64 ILYNRLKDYLIQKLALLRETIVKDNTHDYEFLGTMARLWEVQCHCFKITGDLMMYMDKVYCKPNR 128

  Fly   295 VDNVYNLGLILFRDQVVR--YSEIQKAL-----REKLLGMVMEERHGEAINHLAI-KNACSMLIT 351
            ...||::.|.|||.::::  .|.:..||     |.:.||.|..|       |.:: |....|:.|
Yeast   129 CMEVYDMCLDLFRIEILQKCSSSLISALISDIERIRNLGSVDSE-------HTSLWKVLIGMMET 186

  Fly   352 LGINSRTVYEEDFEKPFLAQSAAFYK----------FESQNFLAENNAGVYIKKVEARITEESSR 406
            |..|..:.:..|||...::.:..:|.          .||            ::|:......||..
Yeast   187 LHDNRDSFFLTDFEPVLISATEEYYNKAIDIELLTPIES------------LEKIRKLRQFESML 239

  Fly   407 AALYLDKDTEPRIVRVVEEELIKKHMRPIVE-MENSGVVYMIKNSKTEDLACTYKLFSRLKEEGL 470
            .:.:|:.|:..::..|:|..||...:..|:| :.:..:|  |.|.|.  |...|.|.|   ||..
Yeast   240 DSSFLNVDSHNKLKTVLENVLIWGKLSDIIEDLTHEAMV--ISNGKL--LQEIYDLSS---EEKY 297

  Fly   471 KV-IADTMSAYLREQGRMLVKEEEN--GNTNPITFVQNLLDLKDRFDQFLVH-SFANDRI----- 526
            :| :.:::.:|:.:....:...|.|  ...|.||:...:::|......||.. .|.:.|:
Yeast   298 RVTVIESIKSYINKNAINIPFNEGNRKKGQNAITWSSEIVELYRSQHSFLESIDFGSVRLNNLTG 362

  Fly   527 -FKNVISSD-FEHFLNLNNKSP-EYLSLFIDDKLKKGGKGMSEQEI----ESILDKTMVLFRFLL 584
             ..|.|..| |..:.:.....| ||||.::|..:|:..:  .:.||    :.:||.|. |...|.
Yeast   363 DVSNAILGDVFSMYFSKEGALPSEYLSTYVDHCMKRTKE--KDAEIVKIKQDLLDSTK-LIGLLT 424

  Fly   585 EKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSVSNTIMDEFK 649
            |||:||:.||..|::|||..:|:. :.||.|:..:|...|..||||||.|.:|:|:|:.:...|:
Yeast   425 EKDIFEKIYKKQLSRRLLQQRSLV-EIEKWMVQMIKKVLGTFFTSKLEIMLRDISLSSEMYQAFQ 488

  Fly   650 NFVNNNNLSLGGVELTVRILTTGFWPTQTATP---NCNIPAAPREAFDIFKNFYLNKHSGRQLTL 711
            :...|   |:..:....::||...||.|:..|   ..::|....:....|:.:|..|:..|.|..
Yeast   489 HSTIN---SIEYLSFAPQVLTRTSWPFQSTNPIDEGISLPPRMSQILAGFEGYYSLKYKERVLKW 550

  Fly   712 QPQMGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTYQMCVLLLFNNRDVL 776
            ...:....|...|                  :||        .:.:..|.|...:.|||.:.:.|
Yeast   551 AHHLSVIEIGCQF------------------NSG--------YYEISFSVYAGVIFLLFEDYEEL 589

  Fly   777 TYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVNDAFNSKFHRVKI 841
            |..:|::.|.||..::...:.|:|. .|..::|.::|.:...      :|.||..|:|...:||:
Yeast   590 TLGEIYELTHIPIDDVKSLVMSMST-IPRCKILKKSSSSGNM------KFSVNYFFSSPNRKVKV 647

  Fly   842 QTVAAKGESE-PERKETRGKV---DEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLP 902
            ..:|....|: .:...|...|   |.:...|:.|.||||||...:|:|..|:...|.:.:||...
Yeast   648 PVIACPLPSQKSDNLATASSVDTYDNEIVMELSAIIVRIMKTEGKLSHQQLLERTTKRTQSRLSL 712

  Fly   903 SPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934
            :|..:|:.|:.|||:||:||:.:|...|:||:
Yeast   713 TPSILKRSIQLLIEKEYIQRNADDPSYYHYLS 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	196..831	CDD:279260	173/673 (26%)
		CULLIN	582..724	CDD:214545	44/144 (31%)
		Cullin_Nedd8	866..926	CDD:287520	24/59 (41%)
CUL3	NP_011517.1	COG5647	1..744	CDD:227934	215/810 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	149	1.000	Domainoid score	I945
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	205	1.000	Inparanoid score	I833
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoFinder	1	1.000	-	-		FOG0000491
OrthoInspector	1	1.000	-	-		oto99964
orthoMCL	1	0.900	-	-		OOG6_102066
Panther	1	1.100	-	-	LDO	PTHR11932
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R263
SonicParanoid	1	1.000	-	-		X2234
TreeFam	1	0.960	-	-
	13	12.860