Protein Alignment Cul3 and CDC53

DIOPT Version :10

• Sequence 1: NP_723909.2
• Gene: Cul3 / 34896
• FlyBaseID: FBgn0261268
• Length: 934
• Species: Drosophila melanogaster
• Sequence 2: NP_010150.1
• Gene: CDC53 / 851424
• SGDID: S000002290
• Length: 815
• Species: Saccharomyces cerevisiae
• Alignment Length: 858
• Identity: 201/858 - (23%)
• Similarity: 357/858 - (41%)
• Gaps: 165/858 - (19%)

  Fly   189 VETIWASLKNAIQEI--QKKNNSGLS-----------FEQLYRNAYNMVLHKH------------ 228
            :|..|..::..|.:|  .:||.:..|           :.::|...||..::|.
Yeast    11 LEATWNFIEPGINQILGNEKNQASTSKRVYKILSPTMYMEVYTAIYNYCVNKSRSSGHFSTDSRT 75

  Fly   229 -------GNRLYYGLREVVSEHLEHKVRADVLEALHSN---FLPKLNQAWTDHQTSMVMIRDILM 283
                   |:.:|        |.|::.::..:|....||   ||....:.|.......:.:.....
Yeast    76 GQSTILVGSEIY--------EKLKNYLKNYILNFKQSNSETFLQFYVKRWKRFTIGAIFLNHAFD 132

  Fly   284 YMDRVYVQ------QREVDNVYNLGLILFRDQVVRYSEIQKALREKLLGMVMEERHGEAINHLAI 342
            ||:|.:||      :|.:.:|..|.|:.:::  |.:...:..|..:||..|...|.|:.|....|
Yeast   133 YMNRYWVQKERSDGKRHIFDVNTLCLMTWKE--VMFDPSKDVLINELLDQVTLGREGQIIQRSNI 195

  Fly   343 KNACSMLITLGINSR-------TVYEEDFEKPFLAQSAAFYKFESQNFLAENNAGVYIKKVEARI 400
            ..|...|:.|||:.:       .||.:.||||||.::..:|...:.::|.:::...||.:....|
Yeast   196 STAIKSLVALGIDPQDLKKLNLNVYIQVFEKPFLKKTQEYYTQYTNDYLEKHSVTEYIFEAHEII 260

  Fly   401 TEESSRAALYLDKDTEPRIVRVVEEELIKKHMRPIVEMENSGVVYMIKNSKTEDLACTYKLFSR- 464
            ..|.....:|.|..|:..:...:.:.||..|   |.::||..|| ::.....|.:...|.|..|
Yeast   261 KREEKAMTIYWDDHTKKPLSMALNKVLITDH---IEKLENEFVV-LLDARDIEKITSLYALIRRD 321

  Fly   465 --------------LKEEGLKVIADTMSAYLREQGRMLVKEEENGN-----------TNPITFVQ 504
                          :|:.|...|:..::.:...     :.:.||.|           .:|..:::
Yeast   322 FTLIPRMASVFENYVKKTGENEISSLLAMHKHN-----IMKNENANPKKLALMTAHSLSPKDYIK 381

  Fly   505 NLLDLKDRFDQFLVHSFANDRIFKNVISSDFEHFLNLN-------------NKSPEYLSLFIDDK 556
            .||::.|.|.:....||.:|......:.:....|:|:|             :|:.|.|:.:.|..
Yeast   382 KLLEVHDIFSKIFNESFPDDIPLAKALDNACGAFININEFALPAGSPKSATSKTSEMLAKYSDIL 446

  Fly   557 LKKGGK-----GMSEQEIESILDKTMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMI 616
            |||..|     .||:::|       :.:|::|.:||.||.:|:...||||:...|.|.:.|:|:|
Yeast   447 LKKATKPEVASDMSDEDI-------ITIFKYLTDKDAFETHYRRLFAKRLIHGTSTSAEDEENII 504

  Fly   617 SKLKTECGCQFTSKLEGMFKDMSVSNTIMDEF----KNFVNNNNLSLGGVELTVRILTTGFWPTQ 677
            .:|:.....::|.|:..||:|:.:|..:.|:|    ||..:.:....  .:|...:|....||..
Yeast   505 QRLQAANSMEYTGKITKMFQDIRLSKILEDDFAVALKNEPDYSKAKY--PDLQPFVLAENMWPFS 567

  Fly   678 TATPNCNIPAAPREAFDIFKNFYLNKHSGRQLTLQPQMGTAYINAVFYGRKAVESEKDKDAPSSS 742
            .......:|.....:.:..|..|..||:||.|        .::..:..|....:..|....|.:
Yeast   568 YQEVEFKLPKELVPSHEKLKESYSQKHNGRIL--------KWLWPLCRGELKADIGKPGRMPFN- 623

  Fly   743 SSGCGVPTTTRKHILQVSTYQMCVLLLFNNRDVLTYDDIHQETDIPERELVRAL------QSLSM 801
                          ..|:.:||.:|||:|:.||||.::|.:.|.:..:.:..|:      :.:..
Yeast   624 --------------FTVTLFQMAILLLYNDADVLTLENIQEGTSLTIQHIAAAMVPFIKFKLIQQ 674

  Fly   802 GKPAQRLLVRNSKTKTKDIEPTDEFYVNDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRK 866
            ..|....||: .:|:.|...|......|..|.|......:|:::..|......|....::.||.:
Yeast   675 VPPGLDALVK-PETQFKLSRPYKALKTNINFASGVKNDILQSLSGGGHDNHGNKLGNKRLTEDER 738

  Fly   867 HE----------IEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQ 921
            .|          :||.|||||||::.|.|..||::..:|...||......:|:.|:.||::.|||
Yeast   739 IEKELNTERQIFLEACIVRIMKAKRNLPHTTLVNECIAQSHQRFNAKVSMVKRAIDSLIQKGYLQ 803

  Fly   922 RSPEDRKVYNYLA 934
            |. :|.:.|.|||
Yeast   804 RG-DDGESYAYLA 815

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	193..832	CDD:459983	163/740 (22%)
		Cullin_Nedd8	864..926	CDD:463146	26/71 (37%)
CDC53	NP_010150.1	COG5647	7..815	CDD:227934	199/856 (23%)