DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul3 and CUL1

DIOPT Version :9

Sequence 1:	NP_723909.2	Gene:	Cul3 / 34896	FlyBaseID:	FBgn0261268	Length:	934	Species:	Drosophila melanogaster
Sequence 2:	NP_001357589.1	Gene:	CUL1 / 8454	HGNCID:	2551	Length:	776	Species:	Homo sapiens

Alignment Length:	807	Identity:	254/807 - (31%)
Similarity:	405/807 - (50%)	Gaps:	108/807 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 VETIWASLKNAIQEIQKKNNSGLS-FEQLYRNAYNMVLHKH------------------------ 228
            ::.||..|:..||::..:.:...| :.:||.:.||.....|
Human    17 LDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQARGAGVPPSKSKKGQTPGGA 81

  Fly   229 ---GNRLYYGLREVVSEHLEHKVRADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYV 290
               |..||..|:|.:..:|.:.:: |..:.:..:.|....|.|.|::.|..::..|..|::|.:|
Human    82 QFVGLELYKRLKEFLKNYLTNLLK-DGEDLMDESVLKFYTQQWEDYRFSSKVLNGICAYLNRHWV 145

  Fly   291 QQREVD-------NVYNLGLILFRDQVVRYSEIQKALREKLLGMVMEERHGEAINHLAIKNACSM 348
             :||.|       .:|:|.|:.:||.:.|  .:.|.:...:|.::.:||:||.||...|......
Human   146 -RRECDEGRKGIYEIYSLALVTWRDCLFR--PLNKQVTNAVLKLIEKERNGETINTRLISGVVQS 207

  Fly   349 LITLGIN---------SRTVYEEDFEKPFLAQSAAFYKFESQNFLAENNAGVYIKKVEARITEES 404
            .:.||:|         :.|||:|.||..|||.:..||..||..||.:|....|:||.|||:.||.
Human   208 YVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEEQ 272

  Fly   405 SRAALYLDKDTEPRIVRVVEEELIKKHMRPI-VEMENSGVVYMIKNSKTEDLACTYKLFSRLKEE 468
            .|..:||.:.|:..:.|..|:.||:||:... .|.:|     ::...|.|||...|.|.||: ::
Human   273 RRVQVYLHESTQDELARKCEQVLIEKHLEIFHTEFQN-----LLDADKNEDLGRMYNLVSRI-QD 331

  Fly   469 GLKVIADTMSAYLREQGRMLVKE-EENGNTNPITFVQNLLDLKDRFDQFLVHSFANDRIFKNVIS 532
            ||..:...:..::..||...::: .|....:|..:||.:||:..:::..::.:|.||..|...:.
Human   332 GLGELKKLLETHIHNQGLAAIEKCGEAALNDPKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALD 396

  Fly   533 SDFEHFLNLN---------NKSPEYLSLFIDDKLKKGGKGMSEQEIESILDKTMVLFRFLLEKDV 588
            .....|:|.|         :||||.|:.:.|..|||..|...|.|:|..|::.||:|:::.:|||
Human   397 KACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKDV 461

  Fly   589 FERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSVSNTIMDEFKNFVN 653
            |:::|...|||||:...|.|||.|.:||||||..||.::||||:.||:|:.||..:.::||..:.
Human   462 FQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLT 526

  Fly   654 NNN-LSLGGVELTVRILTTGFWPTQTATPNCN--IPAAPREAFDIFKNFYLNKHSGRQLTLQPQM 715
            |:. |.|   :.::::|::|.||.|   .:|.  :|:....::..|..||.::||||:||...|:
Human   527 NSEPLDL---DFSIQVLSSGSWPFQ---QSCTFALPSELERSYQRFTAFYASRHSGRKLTWLYQL 585

  Fly   716 GTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTYQMCVLLLFNNRDVLTYDD 780
            ..        |.......|:                  ::.||.||:||.:||.:|..|..|...
Human   586 SK--------GELVTNCFKN------------------RYTLQASTFQMAILLQYNTEDAYTVQQ 624

  Fly   781 IHQETDIPERELVRALQSLSMGKPAQRLLV---RNSKTKTKDIEPTDEFYVNDAFNSKFHRVKIQ 842
            :...|.|....|.:.||.|...|    |||   .|:.....:::|.....:...:.:|..||.|
Human   625 LTDSTQIKMDILAQVLQILLKSK----LLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRVNI- 684

  Fly   843 TVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVFI 907
            .|..|.|.:.|::.|...::||||..|:||||||||.||.|.|..|:.:|.:||.|||.|....|
Human   685 NVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVI 749

  Fly   908 KKRIEGLIEREYLQRSPEDRKVYNYLA 934
            ||.|:.|||:|||:|...::..|:|||
Human   750 KKCIDILIEKEYLERVDGEKDTYSYLA 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	196..831	CDD:279260	203/695 (29%)
		CULLIN	582..724	CDD:214545	54/144 (38%)
		Cullin_Nedd8	866..926	CDD:287520	33/59 (56%)
CUL1	NP_001357589.1	Cullin	21..660	CDD:395716	203/684 (30%)
CUL1	NP_001357589.1	Cullin_Nedd8	706..767	CDD:402267	35/60 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830