DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul3 and CUL3

DIOPT Version :9

Sequence 1:	NP_723909.2	Gene:	Cul3 / 34896	FlyBaseID:	FBgn0261268	Length:	934	Species:	Drosophila melanogaster
Sequence 2:	NP_001244127.1	Gene:	CUL3 / 8452	HGNCID:	2553	Length:	774	Species:	Homo sapiens

Alignment Length:	754	Identity:	524/754 - (69%)
Similarity:	614/754 - (81%)	Gaps:	11/754 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 SMDEKYVETIWASLKNAIQEIQKKNNSGLSFEQLYRNAYNMVLHKHGNRLYYGLREVVSEHLEHK 247
            :||||||.:||..|||||||||:|||||||||:||||||.|||||||.:||.||||||:|||.:|
Human    30 TMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINK 94

  Fly   248 VRADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQQREVDNVYNLGLILFRDQVVR 312
            ||.|||.:|::|||..|||||.||||:||||||||||||||||||..|:||||||||:|||||||
Human    95 VREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVR 159

  Fly   313 YSEIQKALREKLLGMVMEERHGEAINHLAIKNACSMLITLGINSRTVYEEDFEKPFLAQSAAFYK 377
            |..|:..||:.||.|:..||.||.::..||:|||.||:.||:..|:|||||||.|||..||.|::
Human   160 YGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQ 224

  Fly   378 FESQNFLAENNAGVYIKKVEARITEESSRAALYLDKDTEPRIVRVVEEELIKKHMRPIVEMENSG 442
            .|||.|||||:|.||||||||||.||..|....|||.||..||:|||.|||.|||:.||||||||
Human   225 MESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSG 289

  Fly   443 VVYMIKNSKTEDLACTYKLFSRLKEEGLKVIADTMSAYLREQGRMLVKEEENGNTNPITFVQNLL 507
            :|:|:||.|||||.|.||||||: ..|||.:.:.||:||||||:.||.||..|. ||:.::|.||
Human   290 LVHMLKNGKTEDLGCMYKLFSRV-PNGLKTMCECMSSYLREQGKALVSEEGEGK-NPVDYIQGLL 352

  Fly   508 DLKDRFDQFLVHSFANDRIFKNVISSDFEHFLNLNNKSPEYLSLFIDDKLKKGGKGMSEQEIESI 572
            |||.|||:||:.||.|||:||..|:.|||:|||||::||||||||||||||||.||::|||:|:|
Human   353 DLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETI 417

  Fly   573 LDKTMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKD 637
            |||.||||||:.||||||||||.|||:|||.|||||||.||||||||||||||||||||||||:|
Human   418 LDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRD 482

  Fly   638 MSVSNTIMDEFKNFVNNNNLSLGGVELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFKNFYLN 702
            ||:|||.||||:..:....:|||||:||||:||||:||||:|||.||||.|||.||:||:.|||.
Human   483 MSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLA 547

  Fly   703 KHSGRQLTLQPQMGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVP-TTTRKHILQVSTYQMCV 766
            ||||||||||..||:|.:||.|||     ..|.:|.......|..|. :.||||||||||:||.:
Human   548 KHSGRQLTLQHHMGSADLNATFYG-----PVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTI 607

  Fly   767 LLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVNDA 831
            |:|||||:..|:::|.|||||||||||||||||:.|||.||:|.:  :.|:|:||....|.|||.
Human   608 LMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTK--EPKSKEIENGHIFTVNDQ 670

  Fly   832 FNSKFHRVKIQTVAAK-GESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQ 895
            |.||.||||||||||| |||:|||||||.|||:|||||||||||||||:||::.||:||::||.|
Human   671 FTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQ 735

  Fly   896 LKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934
            ||:|||||||.||||||||||||||.|:|||||||.|:|
Human   736 LKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	196..831	CDD:279260	431/635 (68%)
		CULLIN	582..724	CDD:214545	107/141 (76%)
		Cullin_Nedd8	866..926	CDD:287520	47/59 (80%)
CUL3	NP_001244127.1	Cullin	41..670	CDD:279260	431/637 (68%)
		CULLIN	427..569	CDD:214545	107/141 (76%)
		Cullin_Nedd8	706..766	CDD:287520	47/59 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154947
Domainoid	1	1.000	837	1.000	Domainoid score	I60
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2661
Inparanoid	1	1.050	1032	1.000	Inparanoid score	I271
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0000491
OrthoInspector	1	1.000	-	-		oto90785
orthoMCL	1	0.900	-	-		OOG6_102066
Panther	1	1.100	-	-	LDO	PTHR11932
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R263
SonicParanoid	1	1.000	-	-		X2234
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800