Protein Alignment Cul3 and CUL4A

DIOPT Version :10

• Sequence 1: NP_723909.2
• Gene: Cul3 / 34896
• FlyBaseID: FBgn0261268
• Length: 934
• Species: Drosophila melanogaster
• Sequence 2: NP_001008895.1
• Gene: CUL4A / 8451
• HGNCID: 2554
• Length: 759
• Species: Homo sapiens
• Alignment Length: 861
• Identity: 300/861 - (34%)
• Similarity: 451/861 - (52%)
• Gaps: 116/861 - (13%)

  Fly    88 LASASRRSYHLAASGGRVRADNRINTNHPLTPTPLSMPVPAPAAPAVVKTETSATTSGPSTSASA 152
            :|..:.|....:|..||        ||....|..|:   .|||.|.               .|..
Human     1 MADEAPRKGSFSALVGR--------TNGLTKPAALA---AAPAKPG---------------GAGG 39

  Fly   153 SAESTEKRFKEIARKYPLWLPEYKRRAFNASMDEKYVETIWASLKNAIQEIQKKNNSGLSFEQLY 217
            |.:...|.|::..|     ||            :.|.:..|..|..|::.:|...:...:.|:||
Human    40 SKKLVIKNFRDRPR-----LP------------DNYTQDTWRKLHEAVRAVQSSTSIRYNLEELY 87

  Fly   218 RNAYNMVLHKHGNRLYYGLREVVSEHLEHKV---RADVLEALHSNFLPKLNQAWTDHQTSMVMIR 279
            :...|:..||....||..||:...:|::.::   |.|.|:::  .||.|:|..|.||...|:|||
Human    88 QAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSV--LFLKKINTCWQDHCRQMIMIR 150

  Fly   280 DILMYMDRVYV-QQREVDNVYNLGLILFRDQVVRYSEIQKALREKLLGMVMEERHGEAINHLAIK 343
            .|.:::||.|| |...:.:::::||.|||..::....:|....:.:|.::..||.|||::...::
Human   151 SIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLR 215

  Fly   344 NACSMLITLGINSRTVYEEDFEKPFLAQSAAFYKFESQNFLAENNAGVYIKKVEARITEESSRAA 408
            :...||..|     .||::.||..||.::...|..|.|..:.|.....|:..|..|:.||..|..
Human   216 SLLGMLSDL-----QVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVI 275

  Fly   409 LYLDKDTEPRIVRVVEEELIKKHMRPIVEMENSGVVYMIKNSKTEDLACTYKLFSRLKEEGLKVI 473
            .|||..|:..::..||::|:.:|:..|::   .|:.:::..::..|||..|:||||:: .|.:.:
Human   276 TYLDHSTQKPLIACVEKQLLGEHLTAILQ---KGLDHLLDENRVPDLAQMYQLFSRVR-GGQQAL 336

  Fly   474 ADTMSAYLREQGRMLVKEEENGNTNPITFVQNLLDLKDRFDQFLVHSFANDRIFKNVISSDFEHF 538
            ....|.|::..|..:|...|...    ..||:|||.||:.|..:...|..:..|.|::...||.|
Human   337 LQHWSEYIKTFGTAIVINPEKDK----DMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETF 397

  Fly   539 LNLN-NKSPEYLSLFIDDKLKKGGKGMSEQEIESILDKTMVLFRFLLEKDVFERYYKTHLAKRLL 602
            :|.. ||..|.::..:|.||:.|.|..:::|:|..|||.|:||||:..|||||.:||..||||||
Human   398 INKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLL 462

  Fly   603 LNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSVSNTIMDEFKNFVNNNNLSLGGVELTVR 667
            :.||.|.|.||:|:||||.|||..||||||||||||.:|..||..||..:.|.:.| |.::|||.
Human   463 VGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDS-GPIDLTVN 526

  Fly   668 ILTTGFWPTQTATPNCNIPAAPREAF---------DIFKNFYLNKHSGRQLTLQPQMGTAYINAV 723
            |||.|:|||.|          |.|..         ::||.|||.|||||:|..|..:|.|.:.|.
Human   527 ILTMGYWPTYT----------PMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAE 581

  Fly   724 FYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTYQMCVLLLFNNRDVLTYDDIHQETDIP 788
            |     .|.:|:                     .|||.:|..|||:||..|..::::|...|.|.
Human   582 F-----KEGKKE---------------------FQVSLFQTLVLLMFNEGDGFSFEEIKMATGIE 620

  Fly   789 ERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVNDAFNSKFHRVKIQTVAAKGESEPE 853
            :.||.|.||||:.||  .|:|:::  .|.|::|..|:|..|..|..|..|:||..:..| |:..|
Human   621 DSELRRTLQSLACGK--ARVLIKS--PKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMK-ETVEE 680

  Fly   854 RKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEGLIERE 918
            :..|..:|.:||:::|:||||||||.||.|.||||||::.:|||  |...|..:|||||.||:|:
Human   681 QVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLK--FPVKPGDLKKRIESLIDRD 743

  Fly   919 YLQRSPEDRKVYNYLA 934
            |::|..::...|:|:|
Human   744 YMERDKDNPNQYHYVA 759

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	193..832	CDD:459983	231/652 (35%)
		Cullin_Nedd8	864..926	CDD:463146	35/61 (57%)
CUL4A	NP_001008895.1	Cullin	63..660	CDD:459983	231/652 (35%)
		Cullin_Nedd8	688..753	CDD:214883	36/66 (55%)