DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cul3 and CUL4B

DIOPT Version :9

Sequence 1:NP_723909.2 Gene:Cul3 / 34896 FlyBaseID:FBgn0261268 Length:934 Species:Drosophila melanogaster
Sequence 2:NP_003579.3 Gene:CUL4B / 8450 HGNCID:2555 Length:913 Species:Homo sapiens


Alignment Length:948 Identity:324/948 - (34%)
Similarity:503/948 - (53%) Gaps:109/948 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 AGSNNFNGATVGNVDSAVPCRIARQNVLGQQARSMNINVPNASSMQQHQQSQNR------LSAQG 87
            |.:.....||.||. |..|...|::..|...:.|.:    |:|:.::...|.:.      |..:.
Human    33 AAAQEVRSATDGNT-STTPPTSAKKRKLNSSSSSSS----NSSNEREDFDSTSSSSSTPPLQPRD 92

  Fly    88 LASASRRSYHLAASGGRVRADNRINTNHPL--------------------TPTPLSMPVPAPAAP 132
            .||.|..|:.|..|   |.|.:.:.....|                    :.:..|.|..|.:..
Human    93 SASPSTSSFCLGVS---VAASSHVPIQKKLRFEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQ 154

  Fly   133 AVVKTETSATTS-----------GPSTSASASAESTEKRFKEIARKYPLWLPEYKRRAFNASMDE 186
            ..:|.::...:|           ..||:.|:.|.|.....|::..|      .:|.:   ..:.|
Human   155 QQLKNKSILISSVASVHHANGLAKSSTTVSSFANSKPGSAKKLVIK------NFKDK---PKLPE 210

  Fly   187 KYVETIWASLKNAIQEIQKKNNSGLSFEQLYRNAYNMVLHKHGNRLYYGLREVVSEHLE---HKV 248
            .|.:..|..||.|::.||...:...:.|:||:...|:..:|....||..||::..:|::   |:.
Human   211 NYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQF 275

  Fly   249 RADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQQRE-VDNVYNLGLILFRDQVVR 312
            |.|.|:::  .||.|:::.|.:|...|:|||.|.:::||.||.|.. :.:::::||.|||..::.
Human   276 REDSLDSV--LFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIIS 338

  Fly   313 YSEIQKALREKLLGMVMEERHGEAINHLAIKNACSMLITLGINSRTVYEEDFEKPFLAQSAAFYK 377
            ..::|....:.:|.::..||:||||:...:::..|||..|     .:|::.||:.||.::...|.
Human   339 DQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDL-----QIYQDSFEQRFLEETNRLYA 398

  Fly   378 FESQNFLAENNAGVYIKKVEARITEESSRAALYLDKDTEPRIVRVVEEELIKKHMRPIVEMENSG 442
            .|.|..:.|.....|:..|..|:.||:.|...|||:.|:..::..||::|:.:|:..|::   .|
Human   399 AEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQ---KG 460

  Fly   443 VVYMIKNSKTEDLACTYKLFSRLKEEGLKVIADTMSAYLREQGRMLVKEEENGNTNPITFVQNLL 507
            :..::..::.:||:..|:||||:: .|::|:......|::..|..:|...|...    |.||.||
Human   461 LNNLLDENRIQDLSLLYQLFSRVR-GGVQVLLQQWIEYIKAFGSTIVINPEKDK----TMVQELL 520

  Fly   508 DLKDRFDQFLVHSFANDRIFKNVISSDFEHFLNLN-NKSPEYLSLFIDDKLKKGGKGMSEQEIES 571
            |.||:.|..:...|..:..|.|.:...||.|:|.. ||..|.::.::|.||:.|.|..:::|:|.
Human   521 DFKDKVDHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEK 585

  Fly   572 ILDKTMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFK 636
            :|||.|::|||:..|||||.:||..||||||:.||.|.|.||:|:||||.|||..||||||||||
Human   586 MLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFK 650

  Fly   637 DMSVSNTIMDEFKNFVNNNNLSLGGVELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFKNFYL 701
            ||.:|..||.:||.::.|.|:. |.:||||.|||.|:|||.... ..::|....:..:|||.|||
Human   651 DMELSKDIMIQFKQYMQNQNVP-GNIELTVNILTMGYWPTYVPM-EVHLPPEMVKLQEIFKTFYL 713

  Fly   702 NKHSGRQLTLQPQMGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTYQMCV 766
            .|||||:|..|..:|...:.|.|     .|.:|:                     ||||.:|..|
Human   714 GKHSGRKLQWQSTLGHCVLKAEF-----KEGKKE---------------------LQVSLFQTLV 752

  Fly   767 LLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVNDA 831
            ||:||..:..:.::|.|.|.|.:.||.|.||||:.||  .|:|.:|  .|.||||..|:|..||.
Human   753 LLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGK--ARVLAKN--PKGKDIEDGDKFICNDD 813

  Fly   832 FNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQL 896
            |..|..|:||..:..| |:..|:..|..:|.:||:::|:||||||||.||.|:||||||:|.:||
Human   814 FKHKLFRIKINQIQMK-ETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQL 877

  Fly   897 KSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934
            |  |...|..:|||||.||:|:|::|..|:...|||:|
Human   878 K--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA 913

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cul3NP_723909.2 Cullin 196..831 CDD:279260 233/639 (36%)
CULLIN 582..724 CDD:214545 75/141 (53%)
Cullin_Nedd8 866..926 CDD:287520 34/59 (58%)
CUL4BNP_003579.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..100 17/71 (24%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:19801544 55..58 0/2 (0%)
Cullin 218..813 CDD:279260 233/641 (36%)
CULLIN 596..736 CDD:214545 75/141 (53%)
Cullin_Nedd8 842..907 CDD:214883 38/66 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53685
OrthoDB 1 1.010 - - D1040292at2759
OrthoFinder 1 1.000 - - FOG0000491
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.930

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