DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cul3 and CUL2

DIOPT Version :9

Sequence 1:	NP_723909.2	Gene:	Cul3 / 34896	FlyBaseID:	FBgn0261268	Length:	934	Species:	Drosophila melanogaster
Sequence 2:	NP_001318910.1	Gene:	CUL2 / 839415	AraportID:	AT1G02980	Length:	742	Species:	Arabidopsis thaliana

Alignment Length:	777	Identity:	225/777 - (28%)
Similarity:	387/777 - (49%)	Gaps:	67/777 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 EKYVETIWASLKNAIQEIQK---KNNSGLSFE-----QLYRNAYNMVLHK----HGNRLYYGLRE 238
            :..:|..|:.::..:.::||   :......|:     |||...:|:...|    :..::|.....
plant     5 DSVLEAGWSVMEAGVAKLQKILEEVPDEPPFDPVQRMQLYTTVHNLCTQKPPNDYSQQIYDRYGG 69

  Fly   239 VVSEHLEHKVRADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQQREVDNVYNLGL 303
            |..::.:..|...:.|......|.:|.:.|.:.:..:..:.....|:||.|.::.....:..:|.
plant    70 VYVDYNKQTVLPAIREKHGEYMLRELVKRWANQKILVRWLSHFFEYLDRFYTRRGSHPTLSAVGF 134

  Fly   304 ILFRDQVVRYSEIQKALREKLLGMVMEERHGEAINHLAIKNACSMLITLGINSRTVYEEDFEKPF 368
            |.|||.|  |.|:|...::.:|.::.:||.||.|:...:||...:....|:.....||||||...
plant   135 ISFRDLV--YQELQSKAKDAVLALIHKEREGEQIDRALLKNVIDVYCGNGMGELVKYEEDFESFL 197

  Fly   369 LAQSAAFYKFESQNFLAENNAGVYIKKVEARITEESSRAALYLDKDTEPRIVRVVEEELIKKHMR 433
            |..||::|...:..:..||:...|:.|.|..:..|..|...||...|||::|..|:.||:....:
plant   198 LEDSASYYSRNASRWNQENSCPDYMIKAEESLRLEKERVTNYLHSTTEPKLVAKVQNELLVVVAK 262

  Fly   434 PIVEMENSGVVYMIKNSKTEDLACTYKLFSRLKEEGLKVIADTMSAYLREQGRMLVKEEENGNTN 498
            .::|.|:||...::::.|.:|||..|:|:..: .:||..:||....::..:|..|:|:.....|:
plant   263 QLIENEHSGCRALLRDDKMDDLARMYRLYHPI-PQGLDPVADLFKQHITVEGSALIKQATEAATD 326

  Fly   499 PI-----------TFVQNLLDLKDRFDQFLVHSFANDRIFKNVISSDFEHFLN---LNNKSPEYL 549
            ..           ..::.|:||.|:|..::...|....:|...:...||.|.|   ....|.|.|
plant   327 KAASTSGLKVQDQVLIRQLIDLHDKFMVYVDECFQKHSLFHKALKEAFEVFCNKTVAGVSSAEIL 391

  Fly   550 SLFIDDKLKKGG--KGMSEQEIESILDKTMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFE 612
            :.:.|:.||.||  :.:..:::|..|:|.:.|..::.:||:|..:::...|:|||.:::.:|..|
plant   392 ATYCDNILKTGGGIEKLENEDLELTLEKVVKLLVYISDKDLFAEFFRKKQARRLLFDRNGNDYHE 456

  Fly   613 KNMISKLKTECGCQFTSKLEGMFKDMSVSNTIMDEFKNFVNNNNLSLGGVELTVRILTTGFWPTQ 677
            :::::|.|...|.|||||:|||..||:::......|..|::.|.....|::.||.:|||||||:.
plant   457 RSLLTKFKELLGAQFTSKMEGMLTDMTLAKEHQTNFVEFLSVNKTKKLGMDFTVTVLTTGFWPSY 521

  Fly   678 TATPNCNIPAAPREAFDIFKNFYLNKHSGRQLTLQPQMGTAYINAVFYGRKAVESEKDKDAPSSS 742
            ..| :.|:|.......:.||.:|..|.:.|:|:....:||..:...| .:|.:|
plant   522 KTT-DLNLPIEMVNCVEAFKAYYGTKTNSRRLSWIYSLGTCQLAGKF-DKKTIE----------- 573

  Fly   743 SSGCGVPTTTRKHILQVSTYQMCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQR 807
                          :.|:|||..|||||||.:.|:|.:|.::.::...:|.|.|.|||..|  .:
plant   574 --------------IVVTTYQAAVLLLFNNTERLSYTEILEQLNLGHEDLARLLHSLSCLK--YK 622

  Fly   808 LLVRNSKTKTKDIEPTDEFYVNDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAA 872
            :|::  :..:::|..||.|..|..|..|..|:::..     ....|||:....||:||::.|:||
plant   623 ILIK--EPMSRNISNTDTFEFNSKFTDKMRRIRVPL-----PPMDERKKIVEDVDKDRRYAIDAA 680

  Fly   873 IVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934
            :|||||:||.|.|..|||:....|...|.|....||||||.||.|:||:|..::...:.|||
plant   681 LVRIMKSRKVLGHQQLVSECVEHLSKMFKPDIKMIKKRIEDLISRDYLERDTDNPNTFKYLA 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	196..831	CDD:279260	180/662 (27%)
		CULLIN	582..724	CDD:214545	46/141 (33%)
		Cullin_Nedd8	866..926	CDD:287520	30/59 (51%)
CUL2	NP_001318910.1	Cullin	12..645	CDD:366357	181/666 (27%)
CUL2	NP_001318910.1	Cullin_Nedd8	669..736	CDD:214883	34/66 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0000491
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11932
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.930