DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul3 and CUL3

DIOPT Version :9

Sequence 1:	NP_723909.2	Gene:	Cul3 / 34896	FlyBaseID:	FBgn0261268	Length:	934	Species:	Drosophila melanogaster
Sequence 2:	NP_174005.1	Gene:	CUL3 / 839226	AraportID:	AT1G26830	Length:	732	Species:	Arabidopsis thaliana

Alignment Length:	770	Identity:	374/770 - (48%)
Similarity:	511/770 - (66%)	Gaps:	43/770 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 RKYPLWLPEYKRRAFNASMDEKYVETIWASLKNAIQEIQKKNNSGLSFEQLYRNAYNMVLHKHGN 230
            :|....:..:|.|..   :|.||.:..|..|:.||.:|..::.||||||:||||||||||||.|.
plant     5 KKRNFQIEAFKHRVV---VDPKYADKTWQILERAIHQIYNQDASGLSFEELYRNAYNMVLHKFGE 66

  Fly   231 RLYYGLREVVSEHLEHKVRADVLEALH-SNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQQRE 294
            :||.|....::.||:.|  :.::||.. .:||.:||:.|.:|..::.|||||||||||.|::..:
plant    67 KLYTGFIATMTSHLKEK--SKLIEAAQGGSFLEELNKKWNEHNKALEMIRDILMYMDRTYIESTK 129

  Fly   295 VDNVYNLGLILFRDQVVRYSEIQKALREKLLGMVMEERHGEAINHLAIKNACSMLITLGINSRTV 359
            ..:|:.:||.|:||.||.:::|...|...||.:|.:||.||.|:...::|...|.:.||   .:|
plant   130 KTHVHPMGLNLWRDNVVHFTKIHTRLLNTLLDLVQKERIGEVIDRGLMRNVIKMFMDLG---ESV 191

  Fly   360 YEEDFEKPFLAQSAAFYKFESQNFLAENNAGVYIKKVEARITEESSRAALYLDKDTEPRIVRVVE 424
            |:||||||||..|:.|||.|||.|:...:.|.|:||.|.|:|||..|.|.|||..:|.:|..|||
plant   192 YQEDFEKPFLDASSEFYKVESQEFIESCDCGDYLKKSEKRLTEEIERVAHYLDAKSEEKITSVVE 256

  Fly   425 EELIKKHMRPIVEMENSGVVYMIKNSKTEDLACTYKLFSRLKEEGLKVIADTMSAYLREQGRMLV 489
            :|:|..||:.:|.|||||:|.|:.|.|.|||...|.||.|: ..||..:.|.|:::|||.|:.||
plant   257 KEMIANHMQRLVHMENSGLVNMLLNDKYEDLGRMYNLFRRV-TNGLVTVRDVMTSHLREMGKQLV 320

  Fly   490 KEEENGNTNPITFVQNLLDLKDRFDQFLVHSFANDRIFKNVISSDFEHFLNLNNKSPEYLSLFID 554
            .:.|. :.:|:.|||.|||.:|::|:.:..:|.||:.|:|.::|.||:|:|||.:|||::|||:|
plant   321 TDPEK-SKDPVEFVQRLLDERDKYDKIINTAFGNDKTFQNALNSSFEYFINLNARSPEFISLFVD 384

  Fly   555 DKLKKGGKGMSEQEIESILDKTMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKL 619
            |||:||.||:::.::|.||||.|:|||:|.||||||:|||.|||||||..|:||||.|:::|.||
plant   385 DKLRKGLKGITDVDVEVILDKVMMLFRYLQEKDVFEKYYKQHLAKRLLSGKTVSDDAERSLIVKL 449

  Fly   620 KTECGCQFTSKLEGMFKDMSVSNTIMDEFKNFVNNNNLSLGGVELTVRILTTGFWPTQTATPNCN 684
            |||||.||||||||||.||..|.   |..:.|..::.....|..|.|::||||.||||.|.| ||
plant   450 KTECGYQFTSKLEGMFTDMKTSE---DTMRGFYGSHPELSEGPTLIVQVLTTGSWPTQPAVP-CN 510

  Fly   685 IPAAPREAFDIFKNFYLNKHSGRQLTLQPQMGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVP 749
            :||......:.|:::||..|:||:|:.|..||||.|.|:|                    |.|
plant   511 LPAEVSVLCEKFRSYYLGTHTGRRLSWQTNMGTADIKAIF--------------------GKG-- 553

  Fly   750 TTTRKHILQVSTYQMCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSK 814
               :||.|.|||:|||||:||||.|.|:|.:|.|.|:||..:|.|.||||:..|...   |...:
plant   554 ---QKHELNVSTFQMCVLMLFNNSDRLSYKEIEQATEIPAADLKRCLQSLACVKGKN---VIKKE 612

  Fly   815 TKTKDIEPTDEFYVNDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKA 879
            ..:|||...|.|.|||.|.|||::|||.||.|:.|:|||::|||.:|:||||.:||||||||||:
plant   613 PMSKDIGEEDLFVVNDKFTSKFYKVKIGTVVAQKETEPEKQETRQRVEEDRKPQIEAAIVRIMKS 677

  Fly   880 RKRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934
            ||.|.||.::::||.||:.|||.:|..||||||.||||::|:|...|||:|.|||
plant   678 RKILDHNNIIAEVTKQLQPRFLANPTEIKKRIESLIERDFLERDSTDRKLYRYLA 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	196..831	CDD:279260	302/635 (48%)
		CULLIN	582..724	CDD:214545	77/141 (55%)
		Cullin_Nedd8	866..926	CDD:287520	36/59 (61%)
CUL3	NP_174005.1	Cullin	29..630	CDD:395716	304/639 (48%)
CUL3	NP_174005.1	Cullin_Nedd8	662..721	CDD:402267	37/58 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	553	1.000	Domainoid score	I50
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	683	1.000	Inparanoid score	I143
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0000491
OrthoInspector	1	1.000	-	-		otm3226
orthoMCL	1	0.900	-	-		OOG6_102066
Panther	1	1.100	-	-	O	PTHR11932
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2234
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840