DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul3 and CUL4

DIOPT Version :9

Sequence 1:	NP_723909.2	Gene:	Cul3 / 34896	FlyBaseID:	FBgn0261268	Length:	934	Species:	Drosophila melanogaster
Sequence 2:	NP_568658.1	Gene:	CUL4 / 834663	AraportID:	AT5G46210	Length:	792	Species:	Arabidopsis thaliana

Alignment Length:	866	Identity:	309/866 - (35%)
Similarity:	459/866 - (53%)	Gaps:	106/866 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 ASASRRSYHLAASGGRVRADNRINTNHPLT------------PTPLSMPVPAPAAPAVVKTETSA 141
            ||||..|.:.:....:.:.|...:..||.|            |||
plant    13 ASASDDSSYSSPPMKKAKNDLHHSPQHPNTADKVVGFHMEEDPTP-------------------- 57

  Fly   142 TTSGPSTSASASAESTEKRFKEIARKYPLWLPEYKRRAFNASMDEKYVETIWASLKNAIQEIQKK 206
                    |:|:....:....:..:|:.:.|.:.|     .::...:.|..|..|::||:.|..|
plant    58 --------AAANLSRKKATLPQPTKKFVIKLNKAK-----PTLPTNFEENTWEKLQSAIRAIFLK 109

  Fly   207 NNSGLSFEQLYRNAYNMVLHKHGNRLYYGLREVVSEHLEHKVRADVLEALHSN------FLPKLN 265
            .......|.||:...|:.|||...:||..:.:...||:     :..|::|...      ||.::.
plant   110 KKISFDLESLYQAVDNLCLHKLDGKLYDQIEKECEEHI-----SAALQSLVGQNTDLTVFLSRVE 169

  Fly   266 QAWTDHQTSMVMIRDILMYMDRVYV-QQREVDNVYNLGLILFRDQVVRYSEIQKALREKLLGMVM 329
            :.|.|....|:|||.|.:.:||.|| |...|.:::.:||.|||..:....|:::...:.||.|:.
plant   170 KCWQDFCDQMLMIRSIALTLDRKYVIQNPNVRSLWEMGLQLFRKHLSLAPEVEQRTVKGLLSMIE 234

  Fly   330 EERHGEAINHLAIKNACSMLITLGINSRTVYEEDFEKPFLAQSAAFYKFESQNFLAENNAGVYIK 394
            :||..||:|...:.:...|...|||     |.|.||||||..::.||..|...::.:::...|:|
plant   235 KERLAEAVNRTLLSHLLKMFTALGI-----YMESFEKPFLEGTSEFYAAEGMKYMQQSDVPEYLK 294

  Fly   395 KVEARITEESSRAALYLDKDTEPRIVRVVEEELIKKHMRPIVEMENSGVVYMIKNSKTEDLACTY 459
            .||.|:.||:.|..||:|..|...::..||.:|:::|:..::|   .|...::...:||||....
plant   295 HVEGRLHEENERCILYIDAVTRKPLITTVERQLLERHILVVLE---KGFTTLMDGRRTEDLQRMQ 356

  Fly   460 KLFSRLKEEGLKVIADTMSAYLREQGRMLVKEEENGNTNPITFVQNLLDLKDRFDQFLVHSFAND 524
            .||||:  ..|:.:...:|:|:|:.|:.:|.:||...    ..||:|||.|...|.....||..:
plant   357 TLFSRV--NALESLRQALSSYVRKTGQKIVMDEEKDK----DMVQSLLDFKASLDIIWEESFYKN 415

  Fly   525 RIFKNVISSDFEHFLNL-NNKSPEYLSLFIDDKLKKGGKGMSEQEIESILDKTMVLFRFLLEKDV 588
            ..|.|.|...|||.:|| .|:..|.::.|:|:||:.|.||.||:|:||:|:|.:|||||:..|||
plant   416 ESFGNTIKDSFEHLINLRQNRPAELIAKFLDEKLRAGNKGTSEEELESVLEKVLVLFRFIQGKDV 480

  Fly   589 FERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSVSNTIMDEFKNFVN 653
            ||.:||..|||||||.||.|.|.||:||||||||||.|||:||||||||:.:|..|.:.||....
plant   481 FEAFYKKDLAKRLLLGKSASIDAEKSMISKLKTECGSQFTNKLEGMFKDIELSKEINESFKQSSQ 545

  Fly   654 NNNLSLGGVELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFKNFYLNKHSGRQLTLQPQMGTA 718
            .......|:|::|.:||||:|||.... :..:|.......||||.|||:|:|||:|..|..:|..
plant   546 ARTKLPSGIEMSVHVLTTGYWPTYPPM-DVKLPHELNVYQDIFKEFYLSKYSGRRLMWQNSLGHC 609

  Fly   719 YINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTYQMCVLLLFNNRDVLTYDDIHQ 783
            .:.|.|                  |.|        |..|.||.:|..||:|||:...|:::||..
plant   610 VLKADF------------------SKG--------KKELAVSLFQAVVLMLFNDAMKLSFEDIKD 648

  Fly   784 ETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVNDAFNSKFHRVKIQTVAAKG 848
            .|.|.::||.|.||||:.||  .|:|.:|  .|.:|:|..|||..||.|.:..:|:|:..:..|
plant   649 STSIEDKELRRTLQSLACGK--VRVLQKN--PKGRDVEDGDEFEFNDEFAAPLYRIKVNAIQMK- 708

  Fly   849 ESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEG 913
            |:..|...|..:|.:||:::|:||||||||.||.|:|.||::::..|||  |...|..:|||||.
plant   709 ETVEENTSTTERVFQDRQYQIDAAIVRIMKTRKVLSHTLLITELFQQLK--FPIKPADLKKRIES 771

  Fly   914 LIEREYLQRSPEDRKVYNYLA 934
            ||:||||:|...:.::|||||
plant   772 LIDREYLEREKSNPQIYNYLA 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	196..831	CDD:279260	242/642 (38%)
		CULLIN	582..724	CDD:214545	72/141 (51%)
		Cullin_Nedd8	866..926	CDD:287520	32/59 (54%)
CUL4	NP_568658.1	Cullin	96..693	CDD:395716	244/646 (38%)
CUL4	NP_568658.1	Cullin_Nedd8	724..780	CDD:402267	33/57 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0000491
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.830