DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul3 and CUL1

DIOPT Version :9

Sequence 1:	NP_723909.2	Gene:	Cul3 / 34896	FlyBaseID:	FBgn0261268	Length:	934	Species:	Drosophila melanogaster
Sequence 2:	NP_001031575.1	Gene:	CUL1 / 825648	AraportID:	AT4G02570	Length:	738	Species:	Arabidopsis thaliana

Alignment Length:	780	Identity:	248/780 - (31%)
Similarity:	424/780 - (54%)	Gaps:	64/780 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 KRRAFNASMDEKYVETIWASLKNAIQEIQKKNNSGLSFEQLYRNAYNMVL----HKHGNRLYYGL 236
            :|:..:......|::|....||..::.:.:.......:..||...|||..    |.:..:||...
plant     2 ERKTIDLEQGWDYMQTGITKLKRILEGLNEPAFDSEQYMMLYTTIYNMCTQKPPHDYSQQLYDKY 66

  Fly   237 REVVSEHLEHKVRADVLEAL---HSNF-LPKLNQAWTDHQTSMVMIRDILMYMDRVYVQQREVDN 297
            ||...|:    :.:.||.||   |..| |.:|.:.|::|:..:..:.....|:||.::.:|.:..
plant    67 REAFEEY----INSTVLPALREKHDEFMLRELFKRWSNHKVMVRWLSRFFYYLDRYFIARRSLPP 127

  Fly   298 VYNLGLILFRDQVVRYSEIQKALREKLLGMVMEERHGEAINHLAIKNACSMLITLGINSRTVYEE 362
            :..:||..|||.|  |:|:...:::.::.:|.:||.||.|:...:||...:.:.:|:.....|||
plant   128 LNEVGLTCFRDLV--YNELHSKVKQAVIALVDKEREGEQIDRALLKNVLDIYVEIGMGQMERYEE 190

  Fly   363 DFEKPFLAQSAAFYKFESQNFLAENNAGVYIKKVEARITEESSRAALYLDKDTEPRIVRVVEEEL 427
            |||...|..::::|..::.:::.|::...|:.|.|..:.:|..|.|.||...:||::|..|:.||
plant   191 DFESFMLQDTSSYYSRKASSWIQEDSCPDYMLKSEECLKKERERVAHYLHSSSEPKLVEKVQHEL 255

  Fly   428 IKKHMRPIVEMENSGVVYMIKNSKTEDLACTYKLFSRLKEEGLKVIADTMSAYLREQGRMLVKEE 492
            :......::|.|:||...::::.|.:||:..|:|:.::. .||:.:|:....::..:|..||::.
plant   256 LVVFASQLLEKEHSGCRALLRDDKVDDLSRMYRLYHKIL-RGLEPVANIFKQHVTAEGNALVQQA 319

  Fly   493 ENGNTNPI---------TFVQNLLDLKDRFDQFLVHSFANDRIFKNVISSDFEHFLN---LNNKS 545
            |:..||.:         ..::.:::|.|::..::...|.|..:|...:...||.|.|   ..:.|
plant   320 EDTATNQVANTASVQEQVLIRKVIELHDKYMVYVTECFQNHTLFHKALKEAFEIFCNKTVAGSSS 384

  Fly   546 PEYLSLFIDDKLKKGG-KGMSEQEIESILDKTMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSD 609
            .|.|:.|.|:.||||| :.:|::.||..|:|.:.|..::.:||:|..:|:..||:|||.::|.:|
plant   385 AELLATFCDNILKKGGSEKLSDEAIEDTLEKVVKLLAYISDKDLFAEFYRKKLARRLLFDRSAND 449

  Fly   610 DFEKNMISKLKTECGCQFTSKLEGMFKDMSVSNTIMDEFKNFVNNNNLSLGGVELTVRILTTGFW 674
            |.|:::::|||.:||.|||||:|||..|::::....:.|::::.:|..:..|::|||.:||||||
plant   450 DHERSILTKLKQQCGGQFTSKMEGMVTDLTLARENQNSFEDYLGSNPAANPGIDLTVTVLTTGFW 514

  Fly   675 PTQTATPNCNIPAAPREAFDIFKNFYLNKHSGRQLTLQPQMGTAYINAVFYGRKAVESEKDKDAP 739
            |:..:. :.|:|:...:..::||.||..|...|:||....:||.:||..| .:||:|
plant   515 PSYKSF-DINLPSEMIKCVEVFKGFYETKTKHRKLTWIYSLGTCHINGKF-DQKAIE-------- 569

  Fly   740 SSSSSGCGVPTTTRKHILQVSTYQMCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKP 804
                             |.|||||..||||||..|.|:|.:|..:.::...:|||.|.|||..|
plant   570 -----------------LIVSTYQAAVLLLFNTTDKLSYTEILAQLNLSHEDLVRLLHSLSCAK- 616

  Fly   805 AQRLLVRNSKTKTKDIEPTDEFYVNDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEI 869
             .::|::...|||  :...|.|..|..|..:..|:||.....     .|||:....||:||::.|
plant   617 -YKILLKEPNTKT--VSQNDAFEFNSKFTDRMRRIKIPLPPV-----DERKKVVEDVDKDRRYAI 673

  Fly   870 EAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934
            :||||||||:||.|.|..|||:...||...|.|....||||:|.||.|:||:|..|:..::.|||
plant   674 DAAIVRIMKSRKVLGHQQLVSECVEQLSRMFKPDIKAIKKRMEDLITRDYLERDKENPNMFRYLA 738

Fly 935 934
plant 739 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	196..831	CDD:279260	199/655 (30%)
		CULLIN	582..724	CDD:214545	54/141 (38%)
		Cullin_Nedd8	866..926	CDD:287520	31/59 (53%)
CUL1	NP_001031575.1	Cullin	12..641	CDD:395716	201/666 (30%)
CUL1	NP_001031575.1	Cullin_Nedd8	668..729	CDD:402267	33/60 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0000491
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11932
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.930