Protein Alignment Cul3 and CUL5

DIOPT Version :10

• Sequence 1: NP_723909.2
• Gene: Cul3 / 34896
• FlyBaseID: FBgn0261268
• Length: 934
• Species: Drosophila melanogaster
• Sequence 2: NP_003469.2
• Gene: CUL5 / 8065
• HGNCID: 2556
• Length: 780
• Species: Homo sapiens
• Alignment Length: 763
• Identity: 192/763 - (25%)
• Similarity: 339/763 - (44%)
• Gaps: 109/763 - (14%)

  Fly   245 EHKVRADVLEALHSNFLPKLNQAWT---DHQTSMVMIRDILMYMDRVYVQ---------QREV-- 295
            :.|..|.:.:||..:.|..:.||..   .||....:::..::...:.:.|         |.|:
Human    54 DDKGPAKIHQALKEDILEFIKQAQARVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEITL 118

  Fly   296 ---------DNVYNLGLILFRDQVVR-----------YSEIQKALREKLLGMVMEERHGEAINHL 340
                     .||        .|.:||           :|.|:..|::..:.:|..||.|||.:..
Human   119 MGKQGSNKKSNV--------EDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQ 175

  Fly   341 AIKNACSMLITLGINSR---TVYEEDFEKPFLAQSAAFYKFESQNFLAENNAGVYIKKVEARITE 402
            .:.......:.|..|..   .:|.::|||.:|..:..||:.::.::|.:|....|:|..:|::.|
Human   176 LVIGVRESYVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKE 240

  Fly   403 ESSRAALYLDKDTEPRIVRVVEEELIKKHMRPIVEMENSGVVYMIKNSKTEDLACTYKLFSRLKE 467
            |..||..||:...|...|..:.|..:...:....|...:....|||.::||.|...:.|..:: .
Human   241 EEKRALRYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLMDKV-P 304

  Fly   468 EGLKVIADTMSAYLREQGRM-LVKEEENGNTNPITFVQNLLDLKDRFDQFLVHSF--------AN 523
            .|::.:...:..::...|.. :|...|...|:...:|:.||.|.:||.:.:..:|        |.
Human   305 NGIEPMLKDLEEHIISAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTAR 369

  Fly   524 DRIFKNVISSDFEHFLNL-------------NNKSPEYLSLFIDDKLKKG--GKGMSEQEIESIL 573
            |:.:|.|::......|.|             .:|.||.|:.:.|..|:|.  .|.::.:|||:.|
Human   370 DKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTSEEIEAKL 434

  Fly   574 DKTMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECG--CQFTSKLEGMFK 636
            .:.:::.:::..||||.||:|.||.:||:|:.|...:.|:||:..|: |.|  ..:.:||..||:
Human   435 KEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLR-EVGMPADYVNKLARMFQ 498

  Fly   637 DMSVSNTIMDEFKNFVNNNNLSLGGVELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFKNFYL 701
            |:.||..:...||....||.|:|....:.::||..|.|...:.....::|....:.....:.||.
Human   499 DIKVSEDLNQAFKEMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYK 563

  Fly   702 NKHSGRQLTLQPQMGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTYQMCV 766
            ..||||:|.....|....|.                          ......::.|:|:|:|:.|
Human   564 KNHSGRKLHWHHLMSNGIIT--------------------------FKNEVGQYDLEVTTFQLAV 602

  Fly   767 LLLFNN--RDVLTYDDIHQETDIPERELVRALQSLSMGKPAQR--LLVRNSKTKTKDIEPTDEFY 827
            |..:|.  |:.::::::...|::|:.||.|.|.||......:|  ||........||......|.
Human   603 LFAWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYEPQVNSPKDFTEGTLFS 667

  Fly   828 VNDAF----NSKFH-RVKIQTVA-AKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHN 886
            ||..|    |:|.. |.||..:. .:..:|..|:|....:.:.|....:.||::|||.||::::.
Human   668 VNQEFSLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKKISNA 732

  Fly   887 LLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934
            .|.:::...||:.|||....||::||.|||.:|::|...|...:.|:|
Human   733 QLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDESDINTFIYMA 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	193..832	CDD:459983	157/653 (24%)
		Cullin_Nedd8	864..926	CDD:463146	23/61 (38%)
CUL5	NP_003469.2	Cullin	19..672	CDD:459983	157/653 (24%)
		Cullin_Nedd8	711..772	CDD:463146	23/60 (38%)