Protein Alignment Cul3 and Cacul1

DIOPT Version :10

• Sequence 1: NP_723909.2
• Gene: Cul3 / 34896
• FlyBaseID: FBgn0261268
• Length: 934
• Species: Drosophila melanogaster
• Sequence 2: NP_084473.1
• Gene: Cacul1 / 78832
• MGIID: 1926082
• Length: 377
• Species: Mus musculus
• Alignment Length: 294
• Identity: 59/294 - (20%)
• Similarity: 112/294 - (38%)
• Gaps: 84/294 - (28%)

  Fly   116 PLTPTPLSMP-------VPAPAAPAVVKTETSATTSGPSTSASASAESTEKRFKEIARKYPLWLP 173
            |:.|.||..|       ....||.||.|     |...|::|::.:..::..:|
Mouse    83 PMGPPPLPEPNGVIMMLKSCDAAAAVAK-----TAPAPTSSSTININTSTSKF------------ 130

  Fly   174 EYKRRAFNASMDEKYVETIWASLKNAIQEIQKKNNSG---LSFEQLYRNAYNMVLHKHGNRLYYG 235
                 ..|....|.|..|.|..|..||.::..::...   :|:||:|...|..|..:|..::|..
Mouse   131 -----LMNVITIEDYKSTYWPKLDGAIDQLLTQSPGDYIPISYEQIYSCVYKCVCQQHSEQMYSD 190

  Fly   236 LREVVSEHLEHKVRADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQQREVDNVYN 300
            |.:.::.||| :|..::..:....::.:.|.|...:..::..|..:.:||::.|::
Mouse   191 LIKKITSHLE-RVSKELQASPPDLYIERFNIALGQYMGALQSIVPLFIYMNKFYIE--------- 245

  Fly   301 LGLILFRDQVVRYSEIQKALREKLLGMVMEERHGEAINHLAIKNACSMLITLGINSRTVYEEDFE 365
                         :::.:.|::.|:.:..|        |:|.|:..|::
Mouse   246 -------------TKLNRDLKDDLIKLFTE--------HVAEKHIYSLM---------------- 273

  Fly   366 KPFL--AQSAAFYKFESQNFLAENNAGVYIKKVE 397
             |.|  |||..|....|.  :|....|:|..:.|
Mouse   274 -PLLLEAQSTPFQVTPST--MANIVKGLYTLRPE 304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	193..832	CDD:459983	41/210 (20%)
		Cullin_Nedd8	864..926	CDD:463146
Cacul1	NP_084473.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63
		Cullin	145..>269	CDD:459983	29/154 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	347..377