DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul3 and Cul5

DIOPT Version :9

Sequence 1:	NP_723909.2	Gene:	Cul3 / 34896	FlyBaseID:	FBgn0261268	Length:	934	Species:	Drosophila melanogaster
Sequence 2:	NP_082083.3	Gene:	Cul5 / 75717	MGIID:	1922967	Length:	780	Species:	Mus musculus

Alignment Length:	823	Identity:	197/823 - (23%)
Similarity:	358/823 - (43%)	Gaps:	144/823 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 KNNSGLSFEQLYRNAYNMVL---------------------------HKHGNRLYYGLREVVSEH 243
            ||...|.||..:...:.:||                           .|..::::..|:|
Mouse     8 KNKGSLQFEDKWDFMHPIVLKLLRQESVTKQQWFDLFSDVHAVCLWDDKGSSKIHQALKE----- 67

  Fly   244 LEHKVRADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQ---------QREV---- 295
                   |:||     |:.:.......||....:::..::...:.:.|         |.||
Mouse    68 -------DILE-----FIKQAQARVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEVTLLG 120

  Fly   296 ----DNVYNLGLILFRDQVVR-----------YSEIQKALREKLLGMVMEERHGEAINHLAIKNA 345
                :...|:     .|.:||           :|.|:..|::..:.:|..||.|||.:...:...
Mouse   121 KQSSNKKSNM-----EDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGV 180

  Fly   346 CSMLITLGINSR---TVYEEDFEKPFLAQSAAFYKFESQNFLAENNAGVYIKKVEARITEESSRA 407
            ....:.|..|..   .:|.::|||.:|..:..||:.::.::|.:|....|:|..:|::.||..||
Mouse   181 RESYVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEKRA 245

  Fly   408 ALYLDKDTEPRIVRVVEEELIKKHMRPIVEMENSGVVYMIKNSKTEDLACTYKLFSRLKEEGLKV 472
            ..||:...|...|..:.|..:...:....|...:....|||.::||.|...:.|..:: ..|::.
Mouse   246 LRYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLMDKV-PNGIEP 309

  Fly   473 IADTMSAYLREQGRM-LVKEEENGNTNPITFVQNLLDLKDRFDQFLVHSF--------ANDRIFK 528
            :...:..::...|.. :|...|...|:...:|:.||.|.:||.:.:..:|        |.|:.:|
Mouse   310 MLKDLEEHIISAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYK 374

  Fly   529 NVISSDFEHFLNL-------------NNKSPEYLSLFIDDKLKKG--GKGMSEQEIESILDKTMV 578
            .|::......|.|             .:|.||.|:.:.|..|:|.  .|.::.:|||:.|.:.::
Mouse   375 AVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLL 439

  Fly   579 LFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECG--CQFTSKLEGMFKDMSVS 641
            :.:::..||||.||:|.||.:||:|:.|...:.|:||:..|: |.|  ..:.:||..||:|:.||
Mouse   440 VLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLR-EVGMPADYVNKLARMFQDIKVS 503

  Fly   642 NTIMDEFKNFVNNNNLSLGGVELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFKNFYLNKHSG 706
            ..:...||....||.|:|....:.::||..|.|...:.....::|....:.....:.||...|||
Mouse   504 EDLNQAFKEMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYKKNHSG 568

  Fly   707 RQLTLQPQMGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTYQMCVLLLFN 771
            |:|.....|....|.                          ......::.|:|:|:|:.||..:|
Mouse   569 RKLHWHHLMSNGIIT--------------------------FKNEVGQYDLEVTTFQLAVLFAWN 607

  Fly   772 N--RDVLTYDDIHQETDIPERELVRALQSL-SMGKPAQRLLVRNSKTKT-KDIEPTDEFYVNDAF 832
            .  |:.::::::...|::|:.||.|.|.|| :..|..:::|:.:.:..: ||......|.||..|
Mouse   608 QRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYDPQVNSPKDFTEGTLFSVNQDF 672

  Fly   833 ----NSKFH-RVKIQTVA-AKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSD 891
                |:|.. |.||..:. .:..:|..|:|....:.:.|....:.||::|||.||::::..|.::
Mouse   673 SLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKKISNAQLQTE 737

  Fly   892 VTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934
            :...||:.|||....||:::|.|||..|::|...|...:.|:|
Mouse   738 LVEILKNMFLPQKKMIKEQMEWLIEHRYIRRDEADINTFIYMA 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	196..831	CDD:279260	163/712 (23%)
		CULLIN	582..724	CDD:214545	46/143 (32%)
		Cullin_Nedd8	866..926	CDD:287520	21/59 (36%)
Cul5	NP_082083.3	Cullin	19..672	CDD:334305	158/702 (23%)
Cul5	NP_082083.3	Cullin_Nedd8	713..772	CDD:337788	21/58 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820