Protein Alignment Cul3 and cul1

DIOPT Version :10

• Sequence 1: NP_723909.2
• Gene: Cul3 / 34896
• FlyBaseID: FBgn0261268
• Length: 934
• Species: Drosophila melanogaster
• Sequence 2: NP_001039255.1
• Gene: cul1 / 734121
• XenbaseID: XB-GENE-945766
• Length: 776
• Species: Xenopus tropicalis
• Alignment Length: 807
• Identity: 255/807 - (31%)
• Similarity: 405/807 - (50%)
• Gaps: 108/807 - (13%)

  Fly   189 VETIWASLKNAIQEIQKKNNSGLS-FEQLYRNAYNMVLHKH------------------------ 228
            ::.||..|:..||::..:.:...| :.:||.:.||.....|
 Frog    17 LDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQARGAGVPPSKSKKGQTPGGA 81

  Fly   229 ---GNRLYYGLREVVSEHLEHKVRADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYV 290
               |..||..|:|.:..:|.:.:: |..:.:..:.|....|.|.|::.|..::..|..|::|.:|
 Frog    82 QFVGLELYKRLKEFLKNYLTNLLK-DGEDLMDESVLKFYTQQWEDYRFSSKVLNGICAYLNRHWV 145

  Fly   291 QQREVD-------NVYNLGLILFRDQVVRYSEIQKALREKLLGMVMEERHGEAINHLAIKNACSM 348
             :||.|       .:|:|.|:.:||.:  :..:.|.:...:|.::.:||:||.||...|......
 Frog   146 -RRECDEGRKGIYEIYSLALVTWRDCL--FKPLNKQVTNAVLKLIEKERNGETINTRLISGVVQS 207

  Fly   349 LITLGIN---------SRTVYEEDFEKPFLAQSAAFYKFESQNFLAENNAGVYIKKVEARITEES 404
            .:.||:|         :.|||:|.||..|||.:..||..||..||.:|....|:||.|||:.||.
 Frog   208 YVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEEQ 272

  Fly   405 SRAALYLDKDTEPRIVRVVEEELIKKHMRPI-VEMENSGVVYMIKNSKTEDLACTYKLFSRLKEE 468
            .|..:||.:.|:..:.|..|:.||:||:... .|.:|     ::...|.|||...|.|.||: ::
 Frog   273 RRVQVYLHESTQDELARKCEQVLIEKHLEIFHTEFQN-----LLDADKNEDLGRMYNLVSRI-QD 331

  Fly   469 GLKVIADTMSAYLREQGRMLVKE-EENGNTNPITFVQNLLDLKDRFDQFLVHSFANDRIFKNVIS 532
            ||..:...:..::..||...::: .|....:|..:||.:||:..:::..::.:|.||..|...:.
 Frog   332 GLGELKKLLETHIHNQGLAAIEKCGEAAQNDPKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALD 396

  Fly   533 SDFEHFLNLN---------NKSPEYLSLFIDDKLKKGGKGMSEQEIESILDKTMVLFRFLLEKDV 588
            .....|:|.|         :||||.|:.:.|..|||..|...|.|:|..|::.||:|:::.:|||
 Frog   397 KACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKDV 461

  Fly   589 FERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSVSNTIMDEFKNFVN 653
            |:::|...|||||:...|.|||.|.:||||||..||.::||||:.||:|:.||..:.::||..:.
 Frog   462 FQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLT 526

  Fly   654 NNN-LSLGGVELTVRILTTGFWPTQTATPNCN--IPAAPREAFDIFKNFYLNKHSGRQLTLQPQM 715
            |:. |.|   :.::::|::|.||.|..   |.  :|:....::..|..||.::||||:||...|:
 Frog   527 NSEPLDL---DFSIQVLSSGSWPFQQF---CTFALPSELERSYQRFTAFYASRHSGRKLTWLYQL 585

  Fly   716 GTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTYQMCVLLLFNNRDVLTYDD 780
            ..        |.......|:                  ::.||.||:||.:||.:|..|..|...
 Frog   586 SK--------GELVTNCFKN------------------RYTLQASTFQMAILLQYNTEDAYTVQQ 624

  Fly   781 IHQETDIPERELVRALQSLSMGKPAQRLLV---RNSKTKTKDIEPTDEFYVNDAFNSKFHRVKIQ 842
            :...|.|....||:.||.|...|    |||   .|:.....|::|.....:...:.:|..||.|
 Frog   625 LTDSTQIKMDILVQVLQILLKSK----LLVLEDENANVDDVDLKPDILIKLYLGYKNKKLRVNI- 684

  Fly   843 TVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVFI 907
            .|..|.|.:.|::.|...::||||..|:||||||||.||.|.|..|:.:|.:||.|||.|....|
 Frog   685 NVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVI 749

  Fly   908 KKRIEGLIEREYLQRSPEDRKVYNYLA 934
            ||.|:.|||:|||:|...::..|:|||
 Frog   750 KKCIDILIEKEYLERVDGEKDTYSYLA 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	193..832	CDD:459983	205/699 (29%)
		Cullin_Nedd8	864..926	CDD:463146	35/61 (57%)
cul1	NP_001039255.1	Cullin	21..662	CDD:459983	203/686 (30%)
		Cullin_Nedd8	706..768	CDD:463146	35/61 (57%)