Protein Alignment Cul3 and Cul2

DIOPT Version :10

• Sequence 1: NP_723909.2
• Gene: Cul3 / 34896
• FlyBaseID: FBgn0261268
• Length: 934
• Species: Drosophila melanogaster
• Sequence 2: NP_083678.2
• Gene: Cul2 / 71745
• MGIID: 1918995
• Length: 745
• Species: Mus musculus
• Alignment Length: 746
• Identity: 217/746 - (29%)
• Similarity: 367/746 - (49%)
• Gaps: 94/746 - (12%)

  Fly   229 GNRLYYGLREVVSEHLEHKVRADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQQR 293
            |.|||...:..:..|:.|..:. |||: ....|...::.|.::......:..:..|::..|:::.
Mouse    54 GERLYAETKIFLESHVRHLYKR-VLES-EEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQYIKKN 116

  Fly   294 ---EVDNVYNLGLILFRDQVVRYSE-------------IQKALREKLLGMVMEERHGEAINHLAI 342
               |.|..|..|.:...:.::...|             :|..|...||..:..:|.||..|...|
Mouse   117 KLTEADIQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQNILIRMLLREIKNDRGGEDPNQKVI 181

  Fly   343 KNACSMLITLGINSRTVYEEDFEK-------------PFLAQSAAFYKFESQNFLAENNAGVYIK 394
            .         |:.:..|:.|.::|             |||.::..:||.|:.|.|.|:|...|::
Mouse   182 H---------GVINSFVHVEQYKKKFPLKFYQGIFVSPFLTETGEYYKQEASNLLQESNCSQYME 237

  Fly   395 KVEARITEESSRAALYLDKDTEPRIVRVVEEELIKKHMRPIVEMENSGVVYMIKNSKTEDLACTY 459
            ||..|:.:|..|...||...:..:::...::.::..|:    :..:|....:|:..:..|:|..|
Mouse   238 KVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHL----QFLHSECHSIIQQERKNDMANMY 298

  Fly   460 KLFSRLKEEGLKVIADTMSAYLREQG----RMLVKEEENGNTNPITFVQNLLDLKDRFDQFLVHS 520
            .|. |....||..:.:.:..::.::|    ..|.:|.     .|..||:::|::..:|.|.:...
Mouse   299 VLL-RAVSSGLPHMIEELQKHIHDEGLRATSNLTQEH-----MPTLFVESVLEVHGKFVQLINTV 357

  Fly   521 FANDRIFKNVISSDFEHFLNLNN-----KSPEYLSLFIDDKLKKGGKGMSEQEIESILDKTMVLF 580
            ...|:.|.:.:.......:|...     |:||.|:.:.|:.|||..|||:|.|:|..|...:.:|
Mouse   358 LNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDKLTSFITVF 422

  Fly   581 RFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSVSNTIM 645
            :::.:||||:::|...|||||:...|:|.|.|:.||:|||..||.:|||||..|:.|||||..:.
Mouse   423 KYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLN 487

  Fly   646 DEFKNFVNNNNLSLG-GVELTVRILTTGFWP-TQTATPNCNIPAAPREAFDIFKNFYLNKHSGRQ 708
            ::|.||:.|.:..:. |:...:.:|..|.|| ||..:....||....::..:|:.||....|||:
Mouse   488 NKFNNFIRNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRK 552

  Fly   709 LTLQPQMGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTYQMCVLLLFNNR 773
            ||....:.|..:...:.|                          :.::..|:||||.|||.|||.
Mouse   553 LTWLHYLCTGEVKMNYLG--------------------------KPYVAMVTTYQMAVLLAFNNS 591

  Fly   774 DVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVNDAFNSKFHR 838
            :.::|.::...|.:.|:||.:.::||...|      :.|..::.:||:....|.:|.:|:||..:
Mouse   592 ETVSYKELQDSTQMNEKELTKTIKSLLDVK------MINHDSEKEDIDAESSFSLNMSFSSKRTK 650

  Fly   839 VKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPS 903
            .||.|...| ::..|.::||..||||||..::|||||||||||.|.||.|:.:|.||.::||.||
Mouse   651 FKITTSMQK-DTPQELEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPS 714

  Fly   904 PVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934
            ...|||.||.||:::|::||......|:|:|
Mouse   715 ISMIKKCIEVLIDKQYIERSQASADEYSYVA 745

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	193..832	CDD:459983	166/642 (26%)
		Cullin_Nedd8	864..926	CDD:463146	35/61 (57%)
Cul2	NP_083678.2	Cullin	14..644	CDD:459983	166/642 (26%)
		Cullin_Nedd8	675..735	CDD:463146	34/59 (58%)