Protein Alignment Cul3 and Cul5

DIOPT Version :9

• Sequence 1: NP_723909.2
• Gene: Cul3 / 34896
• FlyBaseID: FBgn0261268
• Length: 934
• Species: Drosophila melanogaster
• Sequence 2: XP_006243152.1
• Gene: Cul5 / 64624
• RGDID: 621742
• Length: 828
• Species: Rattus norvegicus
• Alignment Length: 826
• Identity: 197/826 - (23%)
• Similarity: 354/826 - (42%)
• Gaps: 177/826 - (21%)

  Fly   206 KNNSGLSFE-------------------------QLYRNAYNMVL--HKHGNRLYYGLREVVSEH 243
            ||...|.||                         .|:.:.:.:.|  .|..::::..|:|
  Rat    83 KNKGSLQFEDKWDFMRPIVLKLLRQESVTKQQWFDLFSDVHAVCLWDDKGSSKIHQALKE----- 142

  Fly   244 LEHKVRADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQ---------QREV---- 295
                   |:||     |:.:.......||....:::..::...:.:.|         |.||
  Rat   143 -------DILE-----FIKQAQARVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEVTLLG 195

  Fly   296 ----DNVYNLGLILFRDQVVR-----------YSEIQKALREKLLGMVMEERHGEAINHLAIKNA 345
                :...|:     .|.:||           :|.|:..|::..:.:|..||.|||.:...:...
  Rat   196 KQSSNKKSNM-----EDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGV 255

  Fly   346 CSMLITLGINSR---TVYEEDFEKPFLAQSAAFYKFESQNFLAENNAGVYIKKVEARITEESSRA 407
            ....:.|..|..   .:|.::|||.:|..:..||:.::.::|.:|....|:|
  Rat   256 RESYVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMK------------- 307

  Fly   408 ALYLDKDTEPRIVRVVEEELIKKHMRPIVEMENSGVVYMIKNSKTEDLACTYKLFSRLK---EEG 469
              ||.:.....:|...:|.::         .|..|   |||.::||.|...:.|..::.   |..
  Rat   308 --YLMECCVNALVTSFKETIL---------AECQG---MIKRNETEKLHLMFSLMDKVPGGIEPM 358

  Fly   470 LKVIAD-TMSAYLREQGRMLVKEEENGNTNPITFVQNLLDLKDRFDQFLVHSF--------ANDR 525
            ||.:.: .:||.|.:    :|...|...|:...:|:.||.|.:||.:.:..:|        |.|:
  Rat   359 LKDLEEHIISAGLAD----MVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTARDK 419

  Fly   526 IFKNVISSDFEHFLNL-------------NNKSPEYLSLFIDDKLKKG--GKGMSEQEIESILDK 575
            .:|.|::......|.|             .:|.||.|:.:.|..|:|.  .|.::.:|||:.|.:
  Rat   420 AYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTSEEIEAKLKE 484

  Fly   576 TMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECG--CQFTSKLEGMFKDM 638
            .:::.:::..||||.||:|.||.:||:|:.|...:.|:||:..|: |.|  ..:.:||..||:|:
  Rat   485 VLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLR-EVGMPADYVNKLARMFQDI 548

  Fly   639 SVSNTIMDEFKNFVNNNNLSLGGVELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFKNFYLNK 703
            .||..:...||....||.|:|....:.::||..|.|...:.....::|....:.....:.||...
  Rat   549 KVSEDLNQAFKEMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYKKN 613

  Fly   704 HSGRQLTLQPQMGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTYQMCVLL 768
            ||||:|.....|....|.                          ......::.|:|:|:|:.||.
  Rat   614 HSGRKLHWHHLMSNGIIT--------------------------FKNEVGQYDLEVTTFQLAVLF 652

  Fly   769 LFNN--RDVLTYDDIHQETDIPERELVRALQSL-SMGKPAQRLLVRNSKTKT-KDIEPTDEFYVN 829
            .:|.  |:.::::::...|::|:.||.|.|.|| :..|..:::|:.:.:..: ||......|.||
  Rat   653 AWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYDPQVNSPKDFTEGTLFSVN 717

  Fly   830 DAF----NSKFH-RVKIQTVA-AKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLL 888
            ..|    |:|.. |.||..:. .:..:|..|:|....:.:.|....:.||::|||.||::::..|
  Rat   718 QDFSLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKKISNAQL 782

  Fly   889 VSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934
            .:::...||:.|||....||::||.|||.:|::|...|...:.|:|
  Rat   783 QTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDEADINTFIYMA 828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	196..831	CDD:279260	162/715 (23%)
		CULLIN	582..724	CDD:214545	46/143 (32%)
		Cullin_Nedd8	866..926	CDD:287520	22/59 (37%)
Cul5	XP_006243152.1	Cullin	95..719	CDD:279260	157/703 (22%)
		CULLIN	491..634	CDD:214545	46/169 (27%)
		Cullin_Nedd8	761..820	CDD:287520	22/58 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820