DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul3 and cul4b

DIOPT Version :9

Sequence 1:	NP_723909.2	Gene:	Cul3 / 34896	FlyBaseID:	FBgn0261268	Length:	934	Species:	Drosophila melanogaster
Sequence 2:	NP_001116316.1	Gene:	cul4b / 560313	ZFINID:	ZDB-GENE-041008-208	Length:	864	Species:	Danio rerio

Alignment Length:	951	Identity:	325/951 - (34%)
Similarity:	497/951 - (52%)	Gaps:	121/951 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PRQQQPEPLNNLNANGRYHNRMVAGSN---NFNGATVGNVD--SAVPCRIARQNVLGQQARSMNI 65
            |..|:|.|     |....||.....|:   ..|.:...::|  |:.|..|         ..|.:.
Zfish    13 PPAQEPRP-----AASDVHNDSSLTSSKKRKINSSDKEDIDSISSSPKAI---------CNSSST 63

  Fly    66 NVPNASSMQQHQQS--------QNRLSAQGL-ASASRRSYHLAASGGRVRADNRINTNHPLTPTP 121
            ...::||.||.||.        ::.|...|| ...:..|.:.:.|..:.|
Zfish    64 TSCSSSSQQQQQQQHIQKKLRFEDPLDLIGLDVKMAEESCNPSESCSKAR--------------- 113

  Fly   122 LSMPVPAPA---APAVVKTETSATTSGPSTSASASAESTEKRFKEIARKYPLWLPEYKRRAFNAS 183
             ::.:|...   |..:.|:..|||.|  ::...|:.:...|.|||                 ...
Zfish   114 -NVFLPGGVGHHANGLTKSAGSATFS--NSKPGAAKKLVIKNFKE-----------------KPK 158

  Fly   184 MDEKYVETIWASLKNAIQEIQKKNNSGLSFEQLYRNAYNMVLHKHGNRLYYGLREVVSEHLEHKV 248
            :.|.|....|..||.|::.||...:...:.|:||:...|:..||...:||..||.|..:|::.::
Zfish   159 LPENYTNETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSHKISAKLYKQLRVVCEDHIKAQI 223

  Fly   249 ---RADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQQRE-VDNVYNLGLILFRDQ 309
               |.|.|:::  .||.|:::.|.||...|:|||.|.:::||.||.|.. :.:::::||.|||..
Zfish   224 DQFREDALDSV--LFLKKIDKCWQDHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRFY 286

  Fly   310 VVRYSEIQKALREKLLGMVMEERHGEAINHLAIKNACSMLITLGINSRTVYEEDFEKPFLAQSAA 374
            ::...::|....:.:|.::..||.|||::...:::..|||..|     .:|::.||:.||.::..
Zfish   287 IISDLKVQSKTIDGILLLIERERSGEAVDRSLLRSLLSMLSDL-----QIYQDSFEQRFLEETNR 346

  Fly   375 FYKFESQNFLAENNAGVYIKKVEARITEESSRAALYLDKDTEPRIVRVVEEELIKKHMRPIVEME 439
            .|..|.|..:.|.....|:..|..|:.||:.|...|||:.|:..::..||::|:.:|:..|::
Zfish   347 LYAAEGQRLMQEREVPEYLHHVNKRLEEEADRVITYLDQSTQKSLIATVEKQLLGEHLTAILQ-- 409

  Fly   440 NSGVVYMIKNSKTEDLACTYKLFSRLKEEGLKVIADTMSAYLREQGRMLVKEEENGNTNPITFVQ 504
             .|:..::..::.:||:..|:||||:: .|::|:......|::..|..:|...|...    |.||
Zfish   410 -KGLNNLLDENRIQDLSLLYQLFSRVR-GGVQVLLQHWIEYIKAFGSTIVINPEKDK----TMVQ 468

  Fly   505 NLLDLKDRFDQFLVHSFANDRIFKNVISSDFEHFLNLN-NKSPEYLSLFIDDKLKKGGKGMSEQE 568
            .|||.||:.|..:...|..:..|.|.:...||.|:|.. ||..|.::.::|.||:.|.|..:::|
Zfish   469 ELLDFKDKVDHIIDVCFMKNEKFVNGMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEE 533

  Fly   569 IESILDKTMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEG 633
            :|.:|||.|::|||:..|||||.:||..||||||:.||.|.|.||:|:||||.|||..|||||||
Zfish   534 LEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEG 598

  Fly   634 MFKDMSVSNTIMDEFKNFVNNNNLSLGGVELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFKN 698
            |||||.:|..||.:||..:...|:. |.:||||.|||.|:|||.... ..::||......:|||.
Zfish   599 MFKDMELSKDIMVQFKQHMQCQNIP-GNIELTVNILTMGYWPTYVPM-EVHLPAEMVRLQEIFKT 661

  Fly   699 FYLNKHSGRQLTLQPQMGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTYQ 763
            |||.|||||:|..|..:|...:.|.|     .|.:|:                     ||||.:|
Zfish   662 FYLGKHSGRKLQWQSTLGHCVLKAEF-----KEGKKE---------------------LQVSLFQ 700

  Fly   764 MCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYV 828
            ..|||:||..:..:.:||...|.|.:.||.|.||||:.||  .|:|.:  ..|:||:|..|:|..
Zfish   701 TLVLLMFNEGEEFSLEDIKLATGIEDSELRRTLQSLACGK--ARVLTK--IPKSKDVEDGDKFSC 761

  Fly   829 NDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVT 893
            ||.|..|..|:||..:..| |:..|:..|..:|.:||:::|:||||||||.||.|:||||||:|.
Zfish   762 NDDFKHKLFRIKINQIQMK-ETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVY 825

  Fly   894 SQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934
            :|||  |...|..:|||||.||:|:|::|..|:...|||:|
Zfish   826 NQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYVA 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	196..831	CDD:279260	232/639 (36%)
		CULLIN	582..724	CDD:214545	75/141 (53%)
		Cullin_Nedd8	866..926	CDD:287520	34/59 (58%)
cul4b	NP_001116316.1	Cullin	169..764	CDD:279260	232/641 (36%)
		CULLIN	547..687	CDD:214545	75/141 (53%)
		Cullin_Nedd8	793..858	CDD:214883	38/66 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0000491
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.930