Protein Alignment Cul3 and cul4a

DIOPT Version :10

• Sequence 1: NP_723909.2
• Gene: Cul3 / 34896
• FlyBaseID: FBgn0261268
• Length: 934
• Species: Drosophila melanogaster
• Sequence 2: NP_001015893.1
• Gene: cul4a / 548647
• XenbaseID: XB-GENE-1014775
• Length: 753
• Species: Xenopus tropicalis
• Alignment Length: 803
• Identity: 300/803 - (37%)
• Similarity: 442/803 - (55%)
• Gaps: 76/803 - (9%)

  Fly   137 TETSATTSGPSTSASASAESTEKRFKEIARKYPLWLPEYKRRAFNASMDEKYVETIWASLKNAIQ 201
            |::||.||.|    |||.:...|.||:                 ...:.:.|.:..|..|:.|:.
 Frog    22 TKSSALTSKP----SASKKLIIKNFKD-----------------KPKLPDSYTQDTWQKLQEAVN 65

  Fly   202 EIQKKNNSGLSFEQLYRNAYNMVLHKHGNRLYYGLREVVSEHLE---HKVRADVLEALHSNFLPK 263
            .|:...:...:.|:||:...|:..:|..:.||..||:|..||::   |:.|.|.|::.  .||.|
 Frog    66 AIESSTSIKYNLEELYQAVENLCSYKVSHTLYKQLRQVCEEHMKAQIHQFREDSLDSF--LFLKK 128

  Fly   264 LNQAWTDHQTSMVMIRDILMYMDRVYVQQRE-VDNVYNLGLILFRDQVVRYSEIQKALREKLLGM 327
            :|:.|.||...|:|||.|.:::||.||.|.. :.:::::||.|||..||....:|....:.:|.:
 Frog   129 VNRCWKDHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRCHVVSDRMVQIKTIDGILKL 193

  Fly   328 VMEERHGEAINHLAIKNACSMLITLGINSRTVYEEDFEKPFLAQSAAFYKFESQNFLAENNAGVY 392
            :.:||.|||::...:::...||..|     .||:|.||..||.::...|..|.|..:.|.....|
 Frog   194 IEQERSGEAVDRSLLRSLLGMLSDL-----QVYKESFETKFLEETNCLYAAEGQRLMQEREVPEY 253

  Fly   393 IKKVEARITEESSRAALYLDKDTEPRIVRVVEEELIKKHMRPIVEMENSGVVYMIKNSKTEDLAC 457
            :..|..|:.||..|...|||..|...::..||::|:.:|:..|::   .|:..|:..::..:|..
 Frog   254 LHHVNRRLEEEVDRVITYLDHGTHKPLIACVEKQLLGEHLTAILQ---KGLKNMLDENRDPELTL 315

  Fly   458 TYKLFSRLKEEGLKVIADTMSAYLREQGRMLVKEEENGNTNPITFVQNLLDLKDRFDQFLVHSFA 522
            .|:||||:| .|..::......|::..|..||...|...    ..||.|||.||..|..:...|.
 Frog   316 MYQLFSRVK-GGQIILLQHWGEYIKNFGSGLVINPEKDK----DMVQELLDFKDNVDHIIDVCFQ 375

  Fly   523 NDRIFKNVISSDFEHFLNLN-NKSPEYLSLFIDDKLKKGGKGMSEQEIESILDKTMVLFRFLLEK 586
            .:..|.|.:...||.|:|.. ||..|.::.::|.||:.|.|..:::|:|.:|||.|::|||:..|
 Frog   376 KNEKFVNTMKESFETFINRRANKPAELIAKYVDSKLRSGNKEATDEELERLLDKIMIIFRFIHGK 440

  Fly   587 DVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSVSNTIMDEFKNF 651
            ||||.:||..||||||:.||.|.|.||:|:||||.|||..||||||||||||.:|..:|.:||..
 Frog   441 DVFEAFYKKDLAKRLLVGKSASVDSEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDVMVQFKQH 505

  Fly   652 VNNNNLSLGGVELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFKNFYLNKHSGRQLTLQPQMG 716
            :.|:: ..|.::|||.|||.|:|||.|.. :.::||...:..:|||.|||.|||||:|..|..:|
 Frog   506 MQNHS-DPGNIDLTVNILTMGYWPTYTPV-DVHLPAEMVKLQEIFKAFYLGKHSGRRLQWQSTLG 568

  Fly   717 TAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTYQMCVLLLFNNRDVLTYDDI 781
            .|.:.|.|       .|:.|:                   ||||.:|..||||||..|...:::|
 Frog   569 HAVLKADF-------KEEKKE-------------------LQVSLFQTLVLLLFNKGDEFGFEEI 607

  Fly   782 HQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVNDAFNSKFHRVKIQTVAA 846
            ...|.|.:.||.|.||||:.||..    |.|...|:||:|..|.|..|..|..|.:|:||..:..
 Frog   608 KITTGIEDNELRRTLQSLACGKAR----VLNKSPKSKDVEDGDRFCFNADFKHKLYRIKINQIQM 668

  Fly   847 KGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVFIKKRI 911
            | |:..|:..|..:|.:||:::|:||||||||.||.|.||||||::.:|||  |...|..:||||
 Frog   669 K-ETVEEQVNTTERVFQDRQYQIDAAIVRIMKMRKTLTHNLLVSELYNQLK--FPVKPGDLKKRI 730

  Fly   912 EGLIEREYLQRSPEDRKVYNYLA 934
            |.||:|:|::|..::.|.|:|||
 Frog   731 ESLIDRDYMERDKDNAKQYHYLA 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	193..832	CDD:459983	237/643 (37%)
		Cullin_Nedd8	864..926	CDD:463146	35/61 (57%)
cul4a	NP_001015893.1	Cullin	57..654	CDD:459983	237/643 (37%)
		Cullin_Nedd8	685..745	CDD:463146	35/61 (57%)