Protein Alignment Cul3 and mr

DIOPT Version :9

• Sequence 1: NP_723909.2
• Gene: Cul3 / 34896
• FlyBaseID: FBgn0261268
• Length: 934
• Species: Drosophila melanogaster
• Sequence 2: NP_611862.1
• Gene: mr / 45906
• FlyBaseID: FBgn0002791
• Length: 802
• Species: Drosophila melanogaster
• Alignment Length: 621
• Identity: 104/621 - (16%)
• Similarity: 203/621 - (32%)
• Gaps: 184/621 - (29%)

  Fly   200 IQEIQKKNNSGLSFEQLYRNAYNMVLHKHGNRLYYGLREVVSEHLEHKVRADVLEALHSNFLPKL 264
            :.::..|.|..| ||.      |::....|:.|...::..:.||:     :|....:......|.
  Fly   218 LTDMVNKTNMKL-FEM------NLIDRLTGSALTALIKLKIKEHI-----SDTCMGIFDRSHLKQ 270

  Fly   265 NQAWTDHQTSMVMIRDILM-YMDRVYVQQREVDNVYNLGLILFRDQVVRYSEIQKALREKLLGMV 328
            .:.|         :.|::| ::..::.:.:..|::.:          :...|..|:.:.||...:
  Fly   271 LETW---------LSDVIMSWLTNIFTEWKSKDSISD----------IEVPESVKSFKVKLTYFM 316

  Fly   329 MEERHGEAINHLAIKNACSMLITLGINSRTVYEEDFEKPFLAQSAAFYKFESQNFLAENNAGVYI 393
            .                                |.|.:..:.|..:.......:..|.::..:.:
  Fly   317 Y--------------------------------ETFAQSVIGQFFSIIIDYPDSIPAIDDLKICM 349

  Fly   394 KKVEARI-TEESSRAALYLDKDTEPRIVR--VVEEELIKKH---MRPIVEMENSGVVYMIKNSKT 452
            :|::.|: ..||.|.:|      |.||:.  |...:::..:   ::.|..::::||:
  Fly   350 EKIDMRVYLTESLRNSL------EARILHPGVNTMDILTGYVAAIKAIRHLDSTGVI-------- 400

  Fly   453 EDLACTYKLFSRLKEEGLKVIADTMSAYLREQG----RMLVKEEENGNTNPITFVQNLLDLKDRF 513
                             |:::...:..|||::.    |::....|.|.|:
  Fly   401 -----------------LEMVTAPIKDYLRKRNDTVRRVVTGLTEEGPTD--------------- 433

  Fly   514 DQFLVHSFANDRIFKNVISSDFEHFLNLNNKSPEYLSLFIDDKL---KKGGKGMSEQEIESILDK 575
               |....|.....|....|..:.|.|..|..|:...  ||..:   ....|..|...|..::|
  Fly   434 ---LSEELAKGETIKECKDSGTDEFSNWENWQPDPFG--IDASIMQYNSSRKMRSADIISMVVD- 492

  Fly   576 TMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSV 640
                  ....|::|...|:..:|.|||.....:.:.|...:..||...|.......|.|.||::.
  Fly   493 ------IYGSKELFMTEYRNLMADRLLAQLDFNSEKEIRNLELLKIRFGESLLHSCEVMLKDVTD 551

  Fly   641 SNTIMDEFKNFVNNNNLSLGG-------VELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFKN 698
            |..|         |.::...|       .:::..|::..|||:.    |......|.|..:.||.
  Fly   552 SKRI---------NAHIHSDGDRTENQLFDISSLIVSAQFWPSF----NKESLQLPEEIENEFKK 603

  Fly   699 F---YLNKHSGRQLTLQPQMGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVS 760
            :   |......|.|..:...|...|. :..|.:.:|                         :.||
  Fly   604 YTKAYEAYKGNRTLNWRTVTGRVNIE-IEIGDRTME-------------------------MVVS 642

  Fly   761 TYQMCVLLLFNNRDVLTYDDIHQETDIPERELVRAL 796
            .....::..|..::..|.:|:...|.:|...|.|.|
  Fly   643 PILAVIIYHFQTKNEWTIEDLSSITKVPASALRRRL 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	196..831	CDD:279260	104/621 (17%)
		CULLIN	582..724	CDD:214545	33/151 (22%)
		Cullin_Nedd8	866..926	CDD:287520
mr	NP_611862.1	CULLIN	494..632	CDD:214545	33/151 (22%)
		APC2	741..800	CDD:198081

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467935
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930