DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul3 and cul1b

DIOPT Version :9

Sequence 1:	NP_723909.2	Gene:	Cul3 / 34896	FlyBaseID:	FBgn0261268	Length:	934	Species:	Drosophila melanogaster
Sequence 2:	NP_998660.1	Gene:	cul1b / 406816	ZFINID:	ZDB-GENE-040426-2887	Length:	774	Species:	Danio rerio

Alignment Length:	807	Identity:	254/807 - (31%)
Similarity:	409/807 - (50%)	Gaps:	110/807 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 VETIWASLKNAIQEIQKKNNSGLS-FEQLYRNAYNMVLHKH------------------------ 228
            :|.||..|::.||::..:.:...| :.:||.:.||.....|
Zfish    17 LEQIWDDLRSGIQQVYTRQSMARSRYMELYTHVYNYCTSVHQARPTGIPSSKPSKKTPTPGGAQF 81

  Fly   229 -GNRLYYGLREVVSEHLEHKVRADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQQ 292
             |..||..|::.:..:|.:.:: |..:.:..:.|....|.|.|::.|..::..|..|::|.:| :
Zfish    82 VGLELYKRLKDFLRSYLTNLLK-DGEDLMDESVLKFYTQQWEDYRFSSKVLDGICAYLNRHWV-R 144

  Fly   293 REVD-------NVYNLGLILFRDQVVRYSEIQKALREKLLGMVMEERHGEAINHLAIKNACSMLI 350
            ||.|       .:|:|.|..:|:.:.|  .:.|.:...:|.:|.:||:||.||...:.......:
Zfish   145 RECDEGRKGIYEIYSLALATWRECLFR--PLNKQVTNAVLKLVEKERNGETINTRLVSGVVQSYV 207

  Fly   351 TLGIN---------SRTVYEEDFEKPFLAQSAAFYKFESQNFLAENNAGVYIKKVEARITEESSR 406
            .||:|         :.:||:|.||..|||.:..||..||..||.:|....|:||.|||:.||..|
Zfish   208 ELGLNEDDAFVKGPTLSVYKEYFEAQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRR 272

  Fly   407 AALYLDKDTEPRIVRVVEEELIKKHMRPI-VEMENSGVVYMIKNSKTEDLACTYKLFSRLKEEGL 470
            ..:||.:.|:..:.|..|:.||:||:... .|.:|     ::...|.|||...|.|.||: .:||
Zfish   273 VQVYLHESTQDELARKCEQVLIEKHLEIFHTEFQN-----LLDADKNEDLGRMYNLVSRI-TDGL 331

  Fly   471 KVIADTMSAYLREQGRMLVKEEENGNT---NPITFVQNLLDLKDRFDQFLVHSFANDRIFKNVIS 532
            ..:...:.:::..||  |...|:.|::   :|..:||..||:..:::..::.:|.||..|...:.
Zfish   332 GELKKLLESHIHNQG--LAAIEKCGDSALNDPKMYVQTTLDVHKKYNALVMSAFNNDAGFVAALD 394

  Fly   533 SDFEHFLNLN---------NKSPEYLSLFIDDKLKKGGKGMSEQEIESILDKTMVLFRFLLEKDV 588
            .....|:|.|         :||||.|:.:.|..|||..|...|.|:|..|::.||:|:::.:|||
Zfish   395 KACGRFINNNAVTRMAQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKDV 459

  Fly   589 FERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSVSNTIMDEFKNFVN 653
            |:::|...|||||:...|.|||.|.:||||||..||.::||||:.||:|:.||..:.::||..::
Zfish   460 FQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLS 524

  Fly   654 NNN-LSLGGVELTVRILTTGFWPTQTATPNCN--IPAAPREAFDIFKNFYLNKHSGRQLTLQPQM 715
            |:. |.|   :.::::|::|.||.|   .:|.  :|:....::..|..||.::||||:||
Zfish   525 NSEPLDL---DFSIQVLSSGSWPFQ---QSCTFALPSELERSYQRFTAFYGSRHSGRKLT----- 578

  Fly   716 GTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTYQMCVLLLFNNRDVLTYDD 780
               ::..:..|.......|:                  ::.||.||:||.:||.||..:..:...
Zfish   579 ---WLYHLSKGELVTNCFKN------------------RYTLQASTFQMAILLQFNTENCYSVQQ 622

  Fly   781 IHQETDIPERELVRALQSLSMGKPAQRLLV---RNSKTKTKDIEPTDEFYVNDAFNSKFHRVKIQ 842
            :...|.|....||:.||.|...|    |||   .|:.....|.:|.....:...:.:|..||.|
Zfish   623 LADSTQIKTDILVQVLQILLKSK----LLVLEDENANIDEMDFKPDTLIKLFLGYKNKKLRVNI- 682

  Fly   843 TVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVFI 907
            .|..|.|.:.|::.|...::||||..|:||||||||.||.|.|..|:::|.:||.|||.|....|
Zfish   683 NVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLAEVLNQLSSRFKPRVPVI 747

  Fly   908 KKRIEGLIEREYLQRSPEDRKVYNYLA 934
            ||.|:.|||:|||:|...::..|:|||
Zfish   748 KKCIDILIEKEYLERVDGEKDTYSYLA 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	196..831	CDD:279260	202/695 (29%)
		CULLIN	582..724	CDD:214545	53/144 (37%)
		Cullin_Nedd8	866..926	CDD:287520	33/59 (56%)
cul1b	NP_998660.1	Cullin	22..660	CDD:279260	200/685 (29%)
		CULLIN	453..588	CDD:214545	54/148 (36%)
		Cullin_Nedd8	701..768	CDD:214883	36/66 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.930