Protein Alignment Cul3 and cul4a

DIOPT Version :10

• Sequence 1: NP_723909.2
• Gene: Cul3 / 34896
• FlyBaseID: FBgn0261268
• Length: 934
• Species: Drosophila melanogaster
• Sequence 2: NP_957321.2
• Gene: cul4a / 394002
• ZFINID: ZDB-GENE-040426-1357
• Length: 745
• Species: Danio rerio
• Alignment Length: 807
• Identity: 292/807 - (36%)
• Similarity: 444/807 - (55%)
• Gaps: 74/807 - (9%)

  Fly   135 VKTETSATTSGPSTSASASAES--TEKRFKEIARKYPLWLPEYKRRAFNASMDEKYVETIWASLK 197
            |:.:..::.:|.|.||.|.|..  ..|.||:                 ...:.:.|.|..|..|:
Zfish     6 VQHQQKSSFNGLSKSAKAGASKKLVIKNFKD-----------------RPKLTDSYTEDTWLKLR 53

  Fly   198 NAIQEIQKKNNSGLSFEQLYRNAYNMVLHKHGNRLYYGLREVVSEHLE---HKVRADVLEALHSN 259
            :|:..||...:...:.|:||:...|:..:|....||..||:|..||::   |:.|.:.|::|  :
Zfish    54 DAVSAIQNSTSIQYNLEELYQAVENLCSYKVSPMLYKQLRQVCEEHVQAQIHQFREESLDSL--S 116

  Fly   260 FLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQQRE-VDNVYNLGLILFRDQVVRYSEIQKALREK 323
            ||.::|:.|.||....:|||.|.:::||.||.|.. :.::::.||.|||..:|..:.:|....:.
Zfish   117 FLKRMNRCWQDHCRQTIMIRSIFLFLDRTYVLQNSLLPSIWDTGLELFRTHIVSDAAVQSRTVQG 181

  Fly   324 LLGMVMEERHGEAINHLAIKNACSMLITLGINSRTVYEEDFEKPFLAQSAAFYKFESQNFLAENN 388
            :|..|..||.||.::...:::...||..|     .||::.||:.||:::...|..|.|..:.|.:
Zfish   182 ILEQVERERSGETVDRSLLRSLLGMLSDL-----QVYKDSFEQRFLSETTRLYAAEGQRLMQERD 241

  Fly   389 AGVYIKKVEARITEESSRAALYLDKDTEPRIVRVVEEELIKKHMRPIVEMENSGVVYMIKNSKTE 453
            ...|:..|..|:.||:.|...|||:.|:..::..||::|:.:||..|::   .|:..::..::..
Zfish   242 VPEYLHHVARRLEEENDRVISYLDQSTQKPLIATVEKQLLGEHMTTILQ---KGLRTLLDENRVC 303

  Fly   454 DLACTYKLFSRLKEEGLKVIADTMSAYLREQGRMLVKEEENGNTNPITFVQNLLDLKDRFDQFLV 518
            :|...|:|||::| .||..:..:...|::..|...|...|...    ..||.|||.||:.|....
Zfish   304 ELTLLYELFSKVK-GGLTALLQSWREYIKSVGAETVCSPERDR----EMVQELLDFKDQMDSVTQ 363

  Fly   519 HSFANDRIFKNVISSDFEHFLNLN-NKSPEYLSLFIDDKLKKGGKGMSEQEIESILDKTMVLFRF 582
            ..|..:..|.|.:...||:|:|.. ||..|.::.::|.||:.|.|..:|:|:|.||||.|::|||
Zfish   364 SCFQRNESFINAMKEAFENFINQRPNKPAELIAKYVDSKLRAGNKEATEEELERILDKIMIIFRF 428

  Fly   583 LLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSVSNTIMDE 647
            :..|||||.:||..||||||:.||.|.|.||:|:||||.|||..||||||||||||.:|..||.:
Zfish   429 IHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQ 493

  Fly   648 FKNFVNNNNLSLGGVELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFKNFYLNKHSGRQLTLQ 712
            ||.::.|.. ....:||||.|||.|:||:.|.. :.::||...:..::||.|||.|||||:|..|
Zfish   494 FKQYMQNQT-EPSNIELTVNILTMGYWPSYTPM-DVHLPAEMVKLQEVFKLFYLGKHSGRKLQWQ 556

  Fly   713 PQMGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTYQMCVLLLFNNRDVLT 777
            |.:|.|.:...|     .|.:|:                     ||||.:|..|||:||..|..:
Zfish   557 PTLGHAVLKTEF-----KEGKKE---------------------LQVSLFQTLVLLMFNESDECS 595

  Fly   778 YDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVNDAFNSKFHRVKIQ 842
            .::|...|.|.|.||.|.||||:.||..    |.|...:.|::|..|.|:.|..|..|..|:||.
Zfish   596 VEEIRVATGIEEGELKRTLQSLACGKAR----VLNKTPRGKEVEDGDRFHFNSDFRHKLFRIKIN 656

  Fly   843 TVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVFI 907
            .:..| |:..|:..|..:|.:||:::|:||:|||||.||.|:||||||::.:|||  |...|..:
Zfish   657 QIQMK-ETVEEQVSTTERVFQDRQYQIDAAVVRIMKMRKTLSHNLLVSELYNQLK--FPVKPADL 718

  Fly   908 KKRIEGLIEREYLQRSPEDRKVYNYLA 934
            |||||.||:|:|::|..|:...|:|:|
Zfish   719 KKRIESLIDRDYMERDKENSNQYHYVA 745

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	193..832	CDD:459983	232/643 (36%)
		Cullin_Nedd8	864..926	CDD:463146	34/61 (56%)
cul4a	NP_957321.2	Cullin	49..646	CDD:459983	232/643 (36%)
		Cullin_Nedd8	677..737	CDD:463146	34/61 (56%)