DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cul3 and AT1G43140

DIOPT Version :9

Sequence 1:	NP_723909.2	Gene:	Cul3 / 34896	FlyBaseID:	FBgn0261268	Length:	934	Species:	Drosophila melanogaster
Sequence 2:	NP_175007.2	Gene:	AT1G43140 / 3767291	AraportID:	AT1G43140	Length:	721	Species:	Arabidopsis thaliana

Alignment Length:	770	Identity:	226/770 - (29%)
Similarity:	382/770 - (49%)	Gaps:	89/770 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 VETIWASLKNAIQEIQK--KNNSGLSFE-----QLYRNAYNMVLHK----HGNRLYYGLREVVSE 242
            :|..|:.:|..:.::|:  ::.|...|:     .||...|:|.|.:    :...||...|.||..
plant    17 LEEGWSVMKTGVAKLQRILEDLSEPPFDPGQYINLYTIIYDMCLQQPPNDYSQELYNKYRGVVDH 81

  Fly   243 HLEHKVRADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQQREVDNVYNLGLILFR 307
            :.:..|...:.|......|.:|.:.|.:|:..:..:.....|:||.||.:|.:..:.::|...|.
plant    82 YNKETVLPSMRERHGEYMLRELVKRWANHKILVRWLSRFCFYLDRFYVARRGLPTLNDVGFTSFH 146

  Fly   308 DQVVRYSEIQKALREKLLGMVMEERHGEAINHLAIKNACSMLITLGINSRTVYEEDFEKPFLAQS 372
            |.|  |.|||...::.||.::.:||.||.|:...:||...:....|:....:||||||...|..:
plant   147 DLV--YQEIQSEAKDVLLALIHKEREGEQIDRTLVKNVIDVYCGNGVGQMVIYEEDFESFLLQDT 209

  Fly   373 AAFYKFESQNFLAENNAGVYIKKVEARITEESSRAALYLDKDTEPRIVRVVEEELIKKHMRPIVE 437
            |::|..::..:..|::...|:.|.|..:..|..|...||...|||::|..|:.||:....:.::|
plant   210 ASYYSRKASRWSQEDSCPDYMLKAEECLKLEKERVTNYLHSTTEPKLVEKVQNELLVVVAKQLIE 274

  Fly   438 MENSGVVYMIKNSKTEDLACTYKLFSRLKEEGLKVIADTMSAYLREQGRMLVKEEENGNTN---- 498
            .|:||.:.::::.|..||:..|:|: ||..:||:.|||....::..:|..|:|:..:..||
plant   275 NEHSGCLALLRDDKMGDLSRMYRLY-RLIPQGLEPIADLFKQHVTAEGNALIKQAADAATNQDAS 338

  Fly   499 -PITFVQNLLDLKDRFDQFLVHSFANDRIFKNVISSDFEHFLN---LNNKSPEYLSLFIDDKLKK 559
             ....|:..::|.|::..::...|....:|..::...||.|.|   ....|.|.|:.:.|:.||.
plant   339 ASQVLVRKEIELHDKYMVYVDECFQKHSLFHKLLKEAFEVFCNKTVAGASSAEILATYCDNILKT 403

  Fly   560 --GGKGMSEQEIESILDKTMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTE 622
              |.:.:|::..|..|:|.:.|..::.:||:|..:|:...|:|||.::|
plant   404 RGGSEKLSDEATEITLEKVVNLLVYISDKDLFAEFYRKKQARRLLFDRS---------------- 452

  Fly   623 CGCQFTSKLEGMFK---DMSVSNTIMDEFKNFVNNNNLSLGGVELTVRILTTGFWPTQTATPNCN 684
                      |:.|   |::::..:...|.::::.|..:..|::.||.:|||||||:...| :.|
plant   453 ----------GIMKEVTDITLARELQTNFVDYLSANMTTKLGIDFTVTVLTTGFWPSYKTT-DLN 506

  Fly   685 IPAAPREAFDIFKNFYLNKHSGRQLTLQPQMGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVP 749
            :|.......:.||.||..|.:.|:|:....:||.:|...| .:|.:|
plant   507 LPTEMVNCVEAFKVFYGTKTNSRRLSWIYSLGTCHILGKF-EKKTME------------------ 552

  Fly   750 TTTRKHILQVSTYQMCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSK 814
                   |.|||||..|||||||.:.|:|.:|.::.::...:|||.|.|||..|  .::|::...
plant   553 -------LVVSTYQAAVLLLFNNAERLSYTEISEQLNLSHEDLVRLLHSLSCLK--YKILIKEPM 608

  Fly   815 TKTKDIEPTDEFYVNDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKA 879
            ::|  |..||.|..|..|..|..::::..     ....|||:....||:||::.|:||:|||||:
plant   609 SRT--ISKTDTFEFNSKFTDKMRKIRVPL-----PPMDERKKVVEDVDKDRRYAIDAALVRIMKS 666

  Fly   880 RKRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934
            ||.|||..|||:....|...|.|....||||||.||.|:||:|..|:...:.|:|
plant   667 RKVLAHQQLVSECVEHLSKMFKPDIKMIKKRIEDLINRDYLERDTENANTFKYVA 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	196..831	CDD:279260	181/658 (28%)
		CULLIN	582..724	CDD:214545	37/144 (26%)
		Cullin_Nedd8	866..926	CDD:287520	31/59 (53%)
AT1G43140	NP_175007.2	Cullin	48..623	CDD:279260	177/634 (28%)
		CULLIN	428..546	CDD:214545	37/144 (26%)
		Cullin_Nedd8	653..713	CDD:287520	31/59 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0000491
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11932
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.930