DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul3 and Cul1

DIOPT Version :9

Sequence 1:	NP_723909.2	Gene:	Cul3 / 34896	FlyBaseID:	FBgn0261268	Length:	934	Species:	Drosophila melanogaster
Sequence 2:	XP_006236471.1	Gene:	Cul1 / 362356	RGDID:	1308157	Length:	777	Species:	Rattus norvegicus

Alignment Length:	799	Identity:	246/799 - (30%)
Similarity:	392/799 - (49%)	Gaps:	109/799 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 VETIWASLKNAIQEIQKKNNSGLS-FEQLYRNAYNMVLHKH------------------------ 228
            ::.||..|:..||::..:.:...| :.:||.:.||.....|
  Rat    17 LDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQARGAGVPPSKSKKGQTPGGA 81

  Fly   229 ---GNRLYYGLREVVSEHLEHKVRADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYV 290
               |..||..|:|.:..:|.:.:: |..:.:..:.|....|.|.|::.|..::..|..|::|.:|
  Rat    82 QFVGLELYKRLKEFLKNYLTNLLK-DGEDLMDESVLKFYTQQWEDYRFSSKVLNGICAYLNRHWV 145

  Fly   291 QQREVD-------NVYNLGLILFRDQVVRYSEIQKALREKLLGMVMEERHGEAINHLAIKNACSM 348
             :||.|       .:|:|.|:.:||.:.|  .:.|.:...:|.::.:||:||.||...|......
  Rat   146 -RRECDEGRKGIYEIYSLALVTWRDCLFR--PLNKQVTNAVLKLIEKERNGETINTRLISGVVQS 207

  Fly   349 LITLGIN---------SRTVYEEDFEKPFLAQSAAFYKFESQNFLAENNAGVYIKKVEARITEES 404
            .:.||:|         :.|||:|.||..|||.:..||..||..||.:|....|:||.|||:.||.
  Rat   208 YVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEEQ 272

  Fly   405 SRAALYLDKDTEPRIVRVVEEELIKKHMRPI-VEMENSGVVYMIKNSKTEDLACTYKLFSRLKEE 468
            .|..:||.:.|:..:.|..|:.||:||:... .|.:|     ::...|.|||...|.|.||: ::
  Rat   273 RRVQVYLHESTQDELARKCEQVLIEKHLEIFHTEFQN-----LLDADKNEDLGRMYNLVSRI-QD 331

  Fly   469 GLKVIADTMSAYLREQGRMLVKE-EENGNTNPITFVQNLLDLKDRFDQFLVHSFANDRIFKNVIS 532
            ||..:...:..::..||...::: .|....:|..:||.:||:..:::..::.:|.||..|...:.
  Rat   332 GLGELKKLLETHIHNQGLAAIEKCGEAALNDPKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALD 396

  Fly   533 SDFEHFLNLN---------NKSPEYLSLFIDDKLKKGGKGMSEQEIESILDKTMVLFRFLLEKDV 588
            .....|:|.|         :||||.|:.:.|..|||..|...|.|:|..|::.||:|:::.:|||
  Rat   397 KACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKDV 461

  Fly   589 FERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSVSNTIMDEFKNFVN 653
            |:::|...|||||:...|.|||.|.:||||||..||.::||||:.||:|:.||..:.::||..:.
  Rat   462 FQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLT 526

  Fly   654 NNN-LSLGGVELTVRILTTGFWPTQTATPNCN--IPAAPREAFDIFKNFYLNKHSGRQLTLQPQM 715
            |:. |.|   :.::::|::|.||.|   .:|.  :|:....::..|..||.::||||:||...|:
  Rat   527 NSEPLDL---DFSIQVLSSGSWPFQ---QSCTFALPSELERSYQRFTAFYASRHSGRKLTWLYQL 585

  Fly   716 GTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTYQMCVLLLFNNRDVLTYDD 780
            ..        |.......|:                  ::.||.||:||.:||.:|..|..|...
  Rat   586 SK--------GELVTNCFKN------------------RYTLQASTFQMAILLQYNTEDAYTVQQ 624

  Fly   781 IHQETDIPERELVRALQSLSMGKPAQRLLV---RNSKTKTKDIEPTDEFYVNDAFNSKFHRVKIQ 842
            :...|.|....|.:.||.|...|    |||   .|:.....:::|.....:...:.:|..||.|
  Rat   625 LTDSTQIKMDILAQVLQILLKSK----LLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRVNI- 684

  Fly   843 TVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVFI 907
            .|..|.|.:.|::.|...::||||..|:||||||||.||.|.|..|:.:|.:||.|||.|....|
  Rat   685 NVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVI 749

  Fly   908 KKRIEGLIEREYLQRSPED 926
            |........|. |..||:|
  Rat   750 KVPPSEAFPRR-LPYSPQD 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	196..831	CDD:279260	203/695 (29%)
		CULLIN	582..724	CDD:214545	54/144 (38%)
		Cullin_Nedd8	866..926	CDD:287520	28/59 (47%)
Cul1	XP_006236471.1	Cullin	21..660	CDD:395716	203/684 (30%)
Cul1	XP_006236471.1	Cullin_Nedd8	706..>750	CDD:402267	24/43 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830