DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul3 and Cul2

DIOPT Version :9

Sequence 1:	NP_723909.2	Gene:	Cul3 / 34896	FlyBaseID:	FBgn0261268	Length:	934	Species:	Drosophila melanogaster
Sequence 2:	XP_006254134.1	Gene:	Cul2 / 361258	RGDID:	1310644	Length:	745	Species:	Rattus norvegicus

Alignment Length:	746	Identity:	217/746 - (29%)
Similarity:	368/746 - (49%)	Gaps:	94/746 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 GNRLYYGLREVVSEHLEHKVRADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQQR 293
            |.|||...:..:..|:.|..:. |||: ....|...::.|.::......:..:..|::..|:::.
  Rat    54 GERLYAETKIFLENHVRHLYKR-VLES-EEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQYIKKN 116

  Fly   294 ---EVDNVYNLGLILFRDQVVRYSE-------------IQKALREKLLGMVMEERHGEAINHLAI 342
               |.|..|..|.:...:.::...|             :|..|...||..:..:|.||..|...|
  Rat   117 KLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQNILIRMLLREIKNDRGGEDPNQKVI 181

  Fly   343 KNACSMLITLGINSRTVYEEDFEK-------------PFLAQSAAFYKFESQNFLAENNAGVYIK 394
            .         |:.:..|:.|.::|             |||.::..:||.|:.|.|.|:|...|::
  Rat   182 H---------GVINSFVHVEQYKKKFPLKFYQGIFVSPFLTETGEYYKQEASNLLQESNCSQYME 237

  Fly   395 KVEARITEESSRAALYLDKDTEPRIVRVVEEELIKKHMRPIVEMENSGVVYMIKNSKTEDLACTY 459
            ||..|:.:|..|...||...:..:::...::.::..|:    :..:|....:|::.:..|:|..|
  Rat   238 KVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHL----QFLHSECHSIIRHERKNDMANMY 298

  Fly   460 KLFSRLKEEGLKVIADTMSAYLREQG----RMLVKEEENGNTNPITFVQNLLDLKDRFDQFLVHS 520
            .|. |....||..:.:.:..::.::|    ..|.:|.     .|..||:::|::..:|.|.:...
  Rat   299 VLL-RAVSSGLPHMIEELQRHIHDEGLRATSNLTQEH-----MPTLFVESVLEVHGKFVQLINTV 357

  Fly   521 FANDRIFKNVISSDFEHFLNLNN-----KSPEYLSLFIDDKLKKGGKGMSEQEIESILDKTMVLF 580
            ...|:.|.:.:.......:|...     |:||.|:.:.|:.|||..|||:|.|:|..|...:.:|
  Rat   358 LNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDKLTSFITVF 422

  Fly   581 RFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSVSNTIM 645
            :::.:||||:::|...|||||:...|:|.|.|:.||:|||..||.:|||||..|:.|||||..:.
  Rat   423 KYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLN 487

  Fly   646 DEFKNFVNNNNLSLG-GVELTVRILTTGFWP-TQTATPNCNIPAAPREAFDIFKNFYLNKHSGRQ 708
            ::|.||:.|.:..:. |:...:.:|..|.|| ||..:....||....::..:|:.||....|||:
  Rat   488 NKFNNFIRNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRK 552

  Fly   709 LTLQPQMGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTYQMCVLLLFNNR 773
            ||....:.|..:...:.|                          :.::..|:||||.|||.|||.
  Rat   553 LTWLHYLCTGEVKMNYLG--------------------------KPYVAMVTTYQMAVLLAFNNS 591

  Fly   774 DVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVNDAFNSKFHR 838
            :.::|.::...|.:.|:||.:.::||...|      :.|..::.:||:....|.:|.:|:||..:
  Rat   592 ETVSYKELQDSTQMNEKELTKTIKSLLDVK------MINHDSEKEDIDAESSFSLNMSFSSKRTK 650

  Fly   839 VKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPS 903
            .||.|...| ::..|.::||..||||||..::|||||||||||.|.||.|:.:|.||.::||.||
  Rat   651 FKITTSMQK-DTPQELEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPS 714

  Fly   904 PVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934
            ...|||.||.||:::|::||......|:|:|
  Rat   715 ISMIKKCIEVLIDKQYIERSQASADEYSYVA 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	196..831	CDD:279260	166/641 (26%)
		CULLIN	582..724	CDD:214545	54/143 (38%)
		Cullin_Nedd8	866..926	CDD:287520	33/59 (56%)
Cul2	XP_006254134.1	Cullin	14..644	CDD:395716	166/642 (26%)
Cul2	XP_006254134.1	Cullin_Nedd8	675..735	CDD:402267	34/59 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830