Protein Alignment Cul3 and Cul4

DIOPT Version :10

• Sequence 1: NP_723909.2
• Gene: Cul3 / 34896
• FlyBaseID: FBgn0261268
• Length: 934
• Species: Drosophila melanogaster
• Sequence 2: NP_610352.2
• Gene: Cul4 / 35780
• FlyBaseID: FBgn0033260
• Length: 821
• Species: Drosophila melanogaster
• Alignment Length: 899
• Identity: 302/899 - (33%)
• Similarity: 465/899 - (51%)
• Gaps: 100/899 - (11%)

  Fly    41 NVDSAVPCRIARQNVLGQQARSMNINVPNASSMQQHQQSQNRLSAQGLASASRRSYHLAASGGRV 105
            |.::...|....:||....|.:.::             .::..:||.:.|||       .:|.|:
  Fly    18 NTENIAACLKKAENVAPTAAAASSV-------------GRSAFAAQNMNSAS-------TNGERL 62

  Fly   106 RADNRINTNHPLTPTPLSMPVPAPAAPAVVKTETSATTSGPSTSASASAESTEKRFKEIARKYPL 170
            ...:::..:|.                   :..|::|||.......|...|.....|:|..|
  Fly    63 PNFSKLGGSHG-------------------EIRTASTTSNLLNRMGAIHNSKPGDVKKIVIK--- 105

  Fly   171 WLPEYKRRAFNASMDEKYVETIWASLKNAIQEIQKKNNSGLSFEQLYRNAYNMVLHKHGNRLYYG 235
               .:|.:   .::.:.|.:..:..|:.|:..||.......|.|:||:...||..||...:||..
  Fly   106 ---NFKDK---PTLPDNYSKDTYVKLEEAVIAIQLSKPIKYSLEELYQAVVNMCSHKMDAQLYAK 164

  Fly   236 LREVVSEHLEHKVRADVLEALHSN---FLPKLNQAWTDHQTSMVMIRDILMYMDRVYV-QQREVD 296
            |:|:..:|::..::...|.....:   .|.|:|..|......|:|||.|.:||||.|| |...|.
  Fly   165 LKELTEQHVKRNIKLKELTGGSMDKLILLEKINHWWLSFCQQMIMIRSIFLYMDRTYVLQNSTVH 229

  Fly   297 NVYNLGLILFRDQVVRYSEIQKALREKLLGMVMEERHGEAINHLAIKNACSMLITLGINSRTVYE 361
            :::::||.|||....:.|.:||...:.||.::.:||.|..::...:|:...||..|     .:|.
  Fly   230 SIWDMGLDLFRIHFAQNSVVQKRTVDGLLTLIEKERQGSTVDRGLLKSLVRMLCDL-----QIYT 289

  Fly   362 EDFEKPFLAQSAAFYKFESQNFLAENNAGVYIKKVEARITEESSRAALYLDKDTEPRIVRVVEEE 426
            ..||:.||..:...||.|||..:.|.....|::.|..|:.||:.|...|||..|:..::..||:|
  Fly   290 SSFEEKFLDATNQLYKAESQRKMQELEVPEYLQHVNKRLAEENERLRHYLDSSTKHPLIYNVEKE 354

  Fly   427 LIKKHMRPIVEMENSGVVYMIKNSKTEDLACTYKLFSRLKEEGLKVIADTMSAYLREQGRMLVKE 491
            |:.:|:..|::   .|:..::::::..||...|.|.||:| .|...:....:.:::::||.:|.:
  Fly   355 LLAEHLTSILQ---KGLDSLLEDNRLSDLTLLYGLLSRVK-NGTSELCGNFNGFIKKKGRTIVID 415

  Fly   492 EENGNTNPITFVQNLLDLKDRFDQFLVHSFANDRIFKNVISSDFEHFLNLN-NKSPEYLSLFIDD 555
            .|...    :.||:|||.||:.|..:...|.::..|.|.:...||.|:|.. ||..|.::.::|.
  Fly   416 PEKDK----SMVQDLLDFKDKMDVIVRTCFEHNEKFTNSLREAFEFFINQRANKPAELIAKYVDM 476

  Fly   556 KLKKGGKGMSEQEIESILDKTMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLK 620
            ||:.|.||.:::|:|..|||.||||||:..|||||.:||..||||||:.||.|.|.||:|:||||
  Fly   477 KLRSGNKGTTDEELEKTLDKIMVLFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDSEKSMLSKLK 541

  Fly   621 TECGCQFTSKLEGMFKDMSVSNTIMDEFKNFVNNNNLSLGGVELTVRILTTGFWPTQTATPNCNI 685
            .|||..||||||||||||.:|..|...|:....:||..:..::|.|.|||.|:|||...| ...:
  Fly   542 QECGGGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHNLDLCVSILTMGYWPTYAPT-EVTM 605

  Fly   686 PAAPREAFDIFKNFYLNKHSGRQLTLQPQMGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPT 750
            |........||..|||.|||||:|..||.:|...:.|.|            ||....
  Fly   606 PPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNCMLRAQF------------DAGPKE-------- 650

  Fly   751 TTRKHILQVSTYQMCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKT 815
                  |.||.:|..||||||::.||:|::|...|.|.:.||.|.||||:.|    |..|.....
  Fly   651 ------LLVSLFQALVLLLFNDKPVLSYEEILAATLIEDGELRRTLQSLACG----RARVITKTP 705

  Fly   816 KTKDIEPTDEFYVNDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKAR 880
            |.::|...|:|..|:.|.:|..|:||..:..| |:..|:|.|..:|.:||:::|:||||||||.|
  Fly   706 KGREILDGDQFDFNNEFTNKLFRIKINQIQMK-ETNEEQKATEERVFQDRQYQIDAAIVRIMKMR 769

  Fly   881 KRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934
            |.|:||||::::.:||  .|...|..:|||||.||:|:|::|..:::..|||:|
  Fly   770 KTLSHNLLITELFNQL--TFPVKPADLKKRIESLIDRDYMERDKDNQNQYNYVA 821

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	193..832	CDD:459983	231/643 (36%)
		Cullin_Nedd8	864..926	CDD:463146	32/61 (52%)
Cul4	NP_610352.2	Cullin	124..722	CDD:459983	231/641 (36%)
		Cullin_Nedd8	753..813	CDD:463146	32/61 (52%)