DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cul3 and Cul4

DIOPT Version :9

Sequence 1:NP_723909.2 Gene:Cul3 / 34896 FlyBaseID:FBgn0261268 Length:934 Species:Drosophila melanogaster
Sequence 2:NP_001163084.1 Gene:Cul4 / 35780 FlyBaseID:FBgn0033260 Length:821 Species:Drosophila melanogaster


Alignment Length:899 Identity:302/899 - (33%)
Similarity:465/899 - (51%) Gaps:100/899 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 NVDSAVPCRIARQNVLGQQARSMNINVPNASSMQQHQQSQNRLSAQGLASASRRSYHLAASGGRV 105
            |.::...|....:||....|.:.::             .::..:||.:.|||       .:|.|:
  Fly    18 NTENIAACLKKAENVAPTAAAASSV-------------GRSAFAAQNMNSAS-------TNGERL 62

  Fly   106 RADNRINTNHPLTPTPLSMPVPAPAAPAVVKTETSATTSGPSTSASASAESTEKRFKEIARKYPL 170
            ...:::..:|.                   :..|::|||.......|...|.....|:|..|   
  Fly    63 PNFSKLGGSHG-------------------EIRTASTTSNLLNRMGAIHNSKPGDVKKIVIK--- 105

  Fly   171 WLPEYKRRAFNASMDEKYVETIWASLKNAIQEIQKKNNSGLSFEQLYRNAYNMVLHKHGNRLYYG 235
               .:|.:   .::.:.|.:..:..|:.|:..||.......|.|:||:...||..||...:||..
  Fly   106 ---NFKDK---PTLPDNYSKDTYVKLEEAVIAIQLSKPIKYSLEELYQAVVNMCSHKMDAQLYAK 164

  Fly   236 LREVVSEHLEHKVRADVLEALHSN---FLPKLNQAWTDHQTSMVMIRDILMYMDRVYV-QQREVD 296
            |:|:..:|::..::...|.....:   .|.|:|..|......|:|||.|.:||||.|| |...|.
  Fly   165 LKELTEQHVKRNIKLKELTGGSMDKLILLEKINHWWLSFCQQMIMIRSIFLYMDRTYVLQNSTVH 229

  Fly   297 NVYNLGLILFRDQVVRYSEIQKALREKLLGMVMEERHGEAINHLAIKNACSMLITLGINSRTVYE 361
            :::::||.|||....:.|.:||...:.||.::.:||.|..::...:|:...||..|     .:|.
  Fly   230 SIWDMGLDLFRIHFAQNSVVQKRTVDGLLTLIEKERQGSTVDRGLLKSLVRMLCDL-----QIYT 289

  Fly   362 EDFEKPFLAQSAAFYKFESQNFLAENNAGVYIKKVEARITEESSRAALYLDKDTEPRIVRVVEEE 426
            ..||:.||..:...||.|||..:.|.....|::.|..|:.||:.|...|||..|:..::..||:|
  Fly   290 SSFEEKFLDATNQLYKAESQRKMQELEVPEYLQHVNKRLAEENERLRHYLDSSTKHPLIYNVEKE 354

  Fly   427 LIKKHMRPIVEMENSGVVYMIKNSKTEDLACTYKLFSRLKEEGLKVIADTMSAYLREQGRMLVKE 491
            |:.:|:..|::   .|:..::::::..||...|.|.||:| .|...:....:.:::::||.:|.:
  Fly   355 LLAEHLTSILQ---KGLDSLLEDNRLSDLTLLYGLLSRVK-NGTSELCGNFNGFIKKKGRTIVID 415

  Fly   492 EENGNTNPITFVQNLLDLKDRFDQFLVHSFANDRIFKNVISSDFEHFLNLN-NKSPEYLSLFIDD 555
            .|...    :.||:|||.||:.|..:...|.::..|.|.:...||.|:|.. ||..|.::.::|.
  Fly   416 PEKDK----SMVQDLLDFKDKMDVIVRTCFEHNEKFTNSLREAFEFFINQRANKPAELIAKYVDM 476

  Fly   556 KLKKGGKGMSEQEIESILDKTMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLK 620
            ||:.|.||.:::|:|..|||.||||||:..|||||.:||..||||||:.||.|.|.||:|:||||
  Fly   477 KLRSGNKGTTDEELEKTLDKIMVLFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDSEKSMLSKLK 541

  Fly   621 TECGCQFTSKLEGMFKDMSVSNTIMDEFKNFVNNNNLSLGGVELTVRILTTGFWPTQTATPNCNI 685
            .|||..||||||||||||.:|..|...|:....:||..:..::|.|.|||.|:|||...| ...:
  Fly   542 QECGGGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHNLDLCVSILTMGYWPTYAPT-EVTM 605

  Fly   686 PAAPREAFDIFKNFYLNKHSGRQLTLQPQMGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPT 750
            |........||..|||.|||||:|..||.:|...:.|.|            ||....        
  Fly   606 PPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNCMLRAQF------------DAGPKE-------- 650

  Fly   751 TTRKHILQVSTYQMCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKT 815
                  |.||.:|..||||||::.||:|::|...|.|.:.||.|.||||:.|    |..|.....
  Fly   651 ------LLVSLFQALVLLLFNDKPVLSYEEILAATLIEDGELRRTLQSLACG----RARVITKTP 705

  Fly   816 KTKDIEPTDEFYVNDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKAR 880
            |.::|...|:|..|:.|.:|..|:||..:..| |:..|:|.|..:|.:||:::|:||||||||.|
  Fly   706 KGREILDGDQFDFNNEFTNKLFRIKINQIQMK-ETNEEQKATEERVFQDRQYQIDAAIVRIMKMR 769

  Fly   881 KRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934
            |.|:||||::::.:||  .|...|..:|||||.||:|:|::|..:::..|||:|
  Fly   770 KTLSHNLLITELFNQL--TFPVKPADLKKRIESLIDRDYMERDKDNQNQYNYVA 821

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cul3NP_723909.2 Cullin 196..831 CDD:279260 231/639 (36%)
CULLIN 582..724 CDD:214545 71/141 (50%)
Cullin_Nedd8 866..926 CDD:287520 30/59 (51%)
Cul4NP_001163084.1 Cullin 124..721 CDD:279260 231/640 (36%)
CULLIN 503..644 CDD:214545 71/141 (50%)
Cullin_Nedd8 750..815 CDD:214883 33/66 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45467949
Domainoid 1 1.000 149 1.000 Domainoid score I945
eggNOG 1 0.900 - - E1_COG5647
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 205 1.000 Inparanoid score I833
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1040292at2759
OrthoFinder 1 1.000 - - FOG0000491
OrthoInspector 1 1.000 - - otm47383
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR11932
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
98.900

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