DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul3 and Cul1

DIOPT Version :9

Sequence 1:	NP_723909.2	Gene:	Cul3 / 34896	FlyBaseID:	FBgn0261268	Length:	934	Species:	Drosophila melanogaster
Sequence 2:	NP_523655.1	Gene:	Cul1 / 35742	FlyBaseID:	FBgn0015509	Length:	774	Species:	Drosophila melanogaster

Alignment Length:	821	Identity:	237/821 - (28%)
Similarity:	403/821 - (49%)	Gaps:	113/821 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 RAFNASMDEKYV--ETIWASLKNAIQEI--QKKNNSGLSFEQLYRNAYNMVLHKH---------- 228
            |:.|:...:|.|  :.||:.|...|.::  .:|:.:...:.:.|.:.|:......
  Fly     3 RSGNSQTTQKLVNLDDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCTSVSAAPSGRSSGK 67

  Fly   229 -------GNRLYYGLREVVSEHLEH---KVRA----DVLEALHSNFLPKLNQAWTDHQTSMVMIR 279
                   |.:||..|.:.:..:|..   |.:|    :||       |.:..:.|..:|.|..::.
  Fly    68 TGGAQLVGKKLYDRLEQFLKSYLSELLTKFKAISGEEVL-------LSRYTKQWKSYQFSSTVLD 125

  Fly   280 DILMYMDRVYVQ------QREVDNVYNLGLILFRDQVVRYSEIQKALREKLLGMVMEERHGEAIN 338
            .|..|::|.:|:      |:.:..:|.|.|:.::..:  :..:.:.:.:.:|..:.|||.|:.||
  Fly   126 GICNYLNRNWVKRECEEGQKGIYKIYRLALVAWKGHL--FQVLNEPVTKAVLKSIEEERQGKLIN 188

  Fly   339 HLAIKNACSMLITLGINSR---------TVYEEDFEKPFLAQSAAFYKFESQNFLAENNAGVYIK 394
            ...:::.....:.|..|..         :||:::||..|:|.::|||:.||..||:.|....|:|
  Fly   189 RSLVRDVIECYVELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLK 253

  Fly   395 KVEARITEESSR--------AALYLDKDTEPRIVRVVEEELIKKHMRPI-VEMENSGVVYMIKNS 450
            .||.|:.||:.|        ...||.:.|...:....||.||:||::.. .|.:|     ::...
  Fly   254 HVENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQN-----LLNAD 313

  Fly   451 KTEDLACTYKLFSRLKEEGLKVIADTMSAYLREQGRMLVKE--EENGNTNPITFVQNLLDLKDRF 513
            :.:||...|.|.: |..:.|..:...:..::..||...:.:  ..:...:|.|:||.:||:..::
  Fly   314 RNDDLKRMYSLVA-LSSKNLTDLKSILENHILHQGTEAIAKCCTTDAANDPKTYVQTILDVHKKY 377

  Fly   514 DQFLVHSFANDRIFKNVISSDFEHFLNLN--------NKSPEYLSLFIDDKLKKGGKGMSEQEIE 570
            :..::.:|.||..|...:......|:|.|        :||||.|:.:.|..|||..|...::|:|
  Fly   378 NALVLTAFNNDNGFVAALDKACGKFINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPEDKELE 442

  Fly   571 SILDKTMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMF 635
            ..|::.||:|:::.:||||::||...|||||:.:.|.|||.|..||||||..||.::|.||:.||
  Fly   443 DNLNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMF 507

  Fly   636 KDMSVSNTIMDEFKNFVNNNNLSLGGVELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFKNFY 700
            :|:.||..:...||.::...||:: .::..:.:|::|.||.|.:. |..:|:....:...|..||
  Fly   508 QDIGVSKDLNSYFKQYLAEKNLTM-EIDFGIEVLSSGSWPFQLSN-NFLLPSELERSVRQFNEFY 570

  Fly   701 LNKHSGRQLTLQPQM--GTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTYQ 763
            ..:||||:|....||  |...:|.              :..:||:           :.||.||:|
  Fly   571 AARHSGRKLNWLYQMCKGELIMNV--------------NRNNSST-----------YTLQASTFQ 610

  Fly   764 MCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYV 828
            |.|||.||::...|...:...|...:..|::.||.|...|    :|..:....:...|.|.|.::
  Fly   611 MSVLLQFNDQLSFTVQQLQDNTQTQQENLIQVLQILLKAK----VLTSSDNENSLTPESTVELFL 671

  Fly   829 NDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVT 893
            :  :.:|..|:.|.. ..|.|.:.|::.....::||||..|:||||||||.||||.|..|:|:|.
  Fly   672 D--YKNKKRRININQ-PLKTELKVEQETVHKHIEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVL 733

  Fly   894 SQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934
            :||.:||.|....|||.|:.|||:|||:|....:..|:|||
  Fly   734 NQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	196..831	CDD:279260	184/696 (26%)
		CULLIN	582..724	CDD:214545	55/143 (38%)
		Cullin_Nedd8	866..926	CDD:287520	34/59 (58%)
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	183/693 (26%)
		CULLIN	454..593	CDD:214545	54/140 (39%)
		Cullin_Nedd8	701..765	CDD:214883	37/63 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467942
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11932
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850