Protein Alignment Cul3 and cul2

DIOPT Version :10

• Sequence 1: NP_723909.2
• Gene: Cul3 / 34896
• FlyBaseID: FBgn0261268
• Length: 934
• Species: Drosophila melanogaster
• Sequence 2: XP_002666627.1
• Gene: cul2 / 336088
• ZFINID: ZDB-GENE-030131-8032
• Length: 745
• Species: Danio rerio
• Alignment Length: 736
• Identity: 215/736 - (29%)
• Similarity: 366/736 - (49%)
• Gaps: 74/736 - (10%)

  Fly   229 GNRLYYGLREVVSEHLEHKVRADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQQR 293
            |.:||...:..:..|:....:. |||: ....|...::.|.::......:..:..|::..::::.
Zfish    54 GEKLYTETKVFLENHVRQLFKR-VLES-EEKVLVMYHRYWEEYSKGAEYMDCLYRYLNTQFIKKN 116

  Fly   294 ---EVDNVYNLGLILFRDQVVRYSE-------------IQKALREKLLGMVMEERHGEAINHLAI 342
               |.|..|..|.:...:.::...|             :|..|..|||..:..:|.||..|...|
Zfish   117 KLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMIEPLQPMLIGKLLKEIKNDRCGEDPNQKVI 181

  Fly   343 KNACSMLITLGINSR----TVYEEDFEKPFLAQSAAFYKFESQNFLAENNAGVYIKKVEARITEE 403
            ....:..:.:....:    ..|:|.||.|||.::..:||.|:.|.|.|:|...|::||..|:.:|
Zfish   182 HGVINSFVHVEQYKKKFPLKFYQEIFEGPFLTKTGEYYKQEASNLLQESNCSQYMEKVLGRLKDE 246

  Fly   404 SSRAALYLDKDTEPRIVRVVEEELIKKHMRPI-VEMENSGVVYMIKNSKTEDLACTYKLFSRLKE 467
            ..|...||...:..:::...::.::..|::.: .|.:|     :|:..|.:|:|..|.|. |...
Zfish   247 EVRCRKYLHPSSYSKVIHECQQRMVADHLQFLHGECQN-----IIRQEKRDDMANMYTLL-RAVS 305

  Fly   468 EGLKVIADTMSAYLREQG-RMLVK-EEENGNTNPITFVQNLLDLKDRFDQFLVHSFANDRIFKNV 530
            .||..:...:..::.::| |..:. .:||   .|..||:::|::..:|.|.:......|:.|.:.
Zfish   306 SGLPHMIQELQVHIHDEGIRATINLSQEN---MPTLFVESVLEVHSKFVQLINTVLNGDQHFMSA 367

  Fly   531 ISSDFEHFLNLNN-----KSPEYLSLFIDDKLKKGGKGMSEQEIESILDKTMVLFRFLLEKDVFE 590
            :.......:|...     |:||.|:.:.|:.|||..|||:|.|:|..|...:.:|:::.:||||:
Zfish   368 LDKALTSVVNYREPKSICKAPELLAKYCDNLLKKSAKGMTENEVEDKLTSFITVFKYIDDKDVFQ 432

  Fly   591 RYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSVSNTIMDEFKNFVNNN 655
            :.|...|||||:...|:|.|.|:.||:|||..||.:|||||..|:.|||||..:.::|.||:...
Zfish   433 KIYARMLAKRLIHGLSLSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSTDLNNKFNNFIKTQ 497

  Fly   656 NLSLG-GVELTVRILTTGFWP-TQTATPNCNIPAAPREAFDIFKNFYLNKHSGRQLTLQPQMGTA 718
            ...:. |:...:.:|..|.|| |...:....||....::..:|:.||....|||:||....:.|.
Zfish   498 ETVVDLGISFQIYVLQAGAWPLTHVPSSTFAIPQELEKSVQMFELFYNQHFSGRKLTWLHYLCTG 562

  Fly   719 YINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTYQMCVLLLFNNRDVLTYDDIHQ 783
            .:...:                          .::.::..|:||||.|||.|||.:.::|.::..
Zfish   563 EVKMNY--------------------------LSKPYVAVVTTYQMAVLLAFNNSETVSYKELQD 601

  Fly   784 ETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVNDAFNSKFHRVKIQTVAAKG 848
            .|.:.|:||.:.::||...|     ::.:...| ::|||...|.:..:|.||..:.||.|...|
Zfish   602 STQMNEKELQKTIKSLLDVK-----MISHDLQK-EEIEPESTFSLIMSFTSKRTKFKITTSMQK- 659

  Fly   849 ESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEG 913
            ::..|.::||..||||||..::|||||||||||.|.||.|:.:|.:|.|:||.||...|||.||.
Zfish   660 DTPQELEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVINQSKARFNPSISMIKKCIEV 724

  Fly   914 LIEREYLQRSPEDRKVYNYLA 934
            ||:::|::||......|:|:|
Zfish   725 LIDKQYIERSQSSADEYSYVA 745

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	193..832	CDD:459983	164/632 (26%)
		Cullin_Nedd8	864..926	CDD:463146	35/61 (57%)
cul2	XP_002666627.1	Cullin	14..644	CDD:459983	164/632 (26%)
		Cullin_Nedd8	675..737	CDD:463146	35/61 (57%)