DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul3 and cul5a

DIOPT Version :9

Sequence 1:	NP_723909.2	Gene:	Cul3 / 34896	FlyBaseID:	FBgn0261268	Length:	934	Species:	Drosophila melanogaster
Sequence 2:	NP_001314988.1	Gene:	cul5a / 327215	ZFINID:	ZDB-GENE-030131-5426	Length:	780	Species:	Danio rerio

Alignment Length:	809	Identity:	199/809 - (24%)
Similarity:	354/809 - (43%)	Gaps:	116/809 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 KNNSGLSFE---QLYRNAYNMVLHKHGNRLYYGLREVVSEHL----EHKVRADVLEALHSNFLPK 263
            ||...|.||   .|.|.....:|.:..........:....|.    :.|..|.:.:||..:.|..
Zfish     8 KNKGSLQFEDKWDLMRPIVLKLLRQESVTKQQWFDQFSDVHAVCLWDDKGPAKIHQALKEDILDF 72

  Fly   264 LNQAWT---DHQTSMVMIRDILMYMDRVYVQ---------QREV-----------DNVYNLGLIL 305
            :.||..   .||....:::..::...:.:.|         |.|:           .||
Zfish    73 IKQAQARVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEITLMGKQGSSKKSNV------- 130

  Fly   306 FRDQVVR-----------YSEIQKALREKLLGMVMEERHGEAINHLAIKNACSMLITLGINSR-- 357
             .|.:||           :|.|:..|::..:.:|..||.|||.:...:.......:.|..|..
Zfish   131 -EDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESYVNLCSNPEDK 194

  Fly   358 -TVYEEDFEKPFLAQSAAFYKFESQNFLAENNAGVYIKKVEARITEESSRAALYLDKDTEPRIVR 421
             .:|.::|||.:|..:..||:.::.::|.:|....|:|..:|::.||..||..||:...|...|:
Zfish   195 LQIYRDNFEKSYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLREEEKRALRYLETRRECNSVQ 259

  Fly   422 VVEEELIKKHMRPIVEMENSGVVYMIKNSKTEDLACTYKLFSRLKEEGLKVIADTMSAYLREQGR 486
            .:.|..:...:....|...:....|||.::|:.|...:.|..:: ..|::.:...:..::...|.
Zfish   260 ALMECCVNALVTSFKETILAECPGMIKRNETDKLHLMFSLMDKV-PNGIEPMLKDLEEHIISAGL 323

  Fly   487 M-LVKEEENGNTNPITFVQNLLDLKDRFDQFLVHSF--------ANDRIFKNVISSDFEHFLNL- 541
            . :|...|...|:...:|:.||.|.:||.:.:..:|        |.|:.:|.|::......|.|
Zfish   324 ADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELP 388

  Fly   542 ------------NNKSPEYLSLFIDDKLKKG--GKGMSEQEIESILDKTMVLFRFLLEKDVFERY 592
                        .:|.||.|:.:.|..|:|.  .|.::.::||..|.:.:::.:::..||||.||
Zfish   389 MKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTSEDIELKLKEVLLVLKYVQNKDVFMRY 453

  Fly   593 YKTHLAKRLLLNKSVSDDFEKNMISKLKTECG--CQFTSKLEGMFKDMSVSNTIMDEFKNFVNNN 655
            :|.||.:||:|:.|...:.|:||:..|: |.|  ..:.:||..||:|:.||..:...||....:|
Zfish   454 HKAHLTRRLILDISADSEIEENMVEWLR-EVGMPADYVNKLARMFQDIKVSEDLNQVFKEMHKHN 517

  Fly   656 NLSLGGVELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFKNFYLNKHSGRQLTLQPQMGTAYI 720
            .|:|....:.::||..|.|...:.....::|....:.....::||...||||:|.....|....|
Zfish   518 KLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEDFYKKNHSGRKLHWHHLMSNGII 582

  Fly   721 NAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTYQMCVLLLFNN--RDVLTYDDIHQ 783
            .                          ......::.|:|:|:|:.||..:|.  |:.::::::..
Zfish   583 T--------------------------FKNEVGQYDLEVTTFQLAVLFAWNQRPREKISFENLKL 621

  Fly   784 ETDIPERELVRALQSLSMGKPAQR--LLVRNSKTKTKDIEPTDEFYVNDAF----NSKFH-RVKI 841
            .|::|:.||.|.|.||......:|  ||.....:..||...:..|:||..|    |||.. |.||
Zfish   622 ATELPDAELRRTLWSLVAFPKLKRQVLLYEPQVSSPKDFTDSTLFFVNQEFSLIKNSKAQKRGKI 686

  Fly   842 QTVA-AKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPV 905
            ..:. .:..:|..|:|....:.:.|....:.||::|||.||::.:..|.:::...||:.|||...
Zfish   687 NLIGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKKITNAQLQTELVEILKNMFLPQKK 751

  Fly   906 FIKKRIEGLIEREYLQRSPEDRKVYNYLA 934
            .||::||.|||.:|::|...|...:.|:|
Zfish   752 MIKEQIEWLIEHKYIKRDETDINTFIYMA 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	196..831	CDD:279260	163/698 (23%)
		CULLIN	582..724	CDD:214545	45/143 (31%)
		Cullin_Nedd8	866..926	CDD:287520	22/59 (37%)
cul5a	NP_001314988.1	Cullin	20..671	CDD:279260	158/686 (23%)
		CULLIN	443..586	CDD:214545	45/169 (27%)
		Cullin_Nedd8	713..772	CDD:287520	22/58 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820