DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul3 and cul3a

DIOPT Version :9

Sequence 1:	NP_723909.2	Gene:	Cul3 / 34896	FlyBaseID:	FBgn0261268	Length:	934	Species:	Drosophila melanogaster
Sequence 2:	NP_955985.2	Gene:	cul3a / 324655	ZFINID:	ZDB-GENE-030131-3376	Length:	774	Species:	Danio rerio

Alignment Length:	758	Identity:	523/758 - (68%)
Similarity:	615/758 - (81%)	Gaps:	9/758 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 RAFNASMDEKYVETIWASLKNAIQEIQKKNNSGLSFEQLYRNAYNMVLHKHGNRLYYGLREVVSE 242
            |||..:||||||..||..|||||||||:|||||||||:||||||.|||||||.:||.||||||:|
Zfish    25 RAFPMTMDEKYVNNIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTE 89

  Fly   243 HLEHKVRADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQQREVDNVYNLGLILFR 307
            ||.:|||.|||.:|::|||..|||||.||||:||||||||||||||||||..|:||||||||:||
Zfish    90 HLINKVREDVLHSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFR 154

  Fly   308 DQVVRYSEIQKALREKLLGMVMEERHGEAINHLAIKNACSMLITLGINSRTVYEEDFEKPFLAQS 372
            ||||||..|:..||:.||.|:..||.||.::..||:|||.||:.||:..|:|||||||.|||..|
Zfish   155 DQVVRYGCIRDHLRQTLLDMIARERRGEVVDRGAIRNACQMLMVLGLEGRSVYEEDFEIPFLDMS 219

  Fly   373 AAFYKFESQNFLAENNAGVYIKKVEARITEESSRAALYLDKDTEPRIVRVVEEELIKKHMRPIVE 437
            |.|::.|||.|||||:|.||||||||||.||..|....|||.||..||:|||.|||.|||:.|||
Zfish   220 AEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVE 284

  Fly   438 MENSGVVYMIKNSKTEDLACTYKLFSRLKEEGLKVIADTMSAYLREQGRMLVKEEENGNTNPITF 502
            |||||:|:|:||.|||||||.||||.|: ..|||.:.:.||.||||||:.||.||..|. ||:.:
Zfish   285 MENSGLVHMLKNGKTEDLACMYKLFGRV-PNGLKTMCECMSWYLREQGKALVSEEGEGK-NPVDY 347

  Fly   503 VQNLLDLKDRFDQFLVHSFANDRIFKNVISSDFEHFLNLNNKSPEYLSLFIDDKLKKGGKGMSEQ 567
            :|.|||||.|||:||..||.|||:||..|:.|||:|||||::||||||||||||||||.||::||
Zfish   348 IQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQ 412

  Fly   568 EIESILDKTMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLE 632
            |:||||||.||||||:.||||||||||.|||:|||.|||||||.|||||||||||||||||||||
Zfish   413 EVESILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLE 477

  Fly   633 GMFKDMSVSNTIMDEFKNFVNNNNLSLGGVELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFK 697
            |||:|||:|||.||||::.:..:.:||.||:||||:||||:||||:|||.||||.:||.||::|:
Zfish   478 GMFRDMSISNTTMDEFRHHLQTSQVSLCGVDLTVRVLTTGYWPTQSATPKCNIPPSPRHAFEVFR 542

  Fly   698 NFYLNKHSGRQLTLQPQMGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTY 762
            .|||.||||||||||..||:|.:||.|||....|...|.....:..:|    :.||||||||||:
Zfish   543 RFYLAKHSGRQLTLQHHMGSADLNATFYGPIKKEDGSDVGVGGALLTG----SNTRKHILQVSTF 603

  Fly   763 QMCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFY 827
            ||.:|:|||||:..|:::|.|||||||||||||||||:.|||.||:|.:  :.|:|:||....|.
Zfish   604 QMTILMLFNNREKFTFEEIQQETDIPERELVRALQSLACGKPTQRVLTK--EPKSKEIESGHVFT 666

  Fly   828 VNDAFNSKFHRVKIQTVAAK-GESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSD 891
            |||.|.||.||||||||||| |||:|||||||.|||:|||||||||||||||:||::.||:||::
Zfish   667 VNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAE 731

  Fly   892 VTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934
            ||.||::|||||||.||||||||||||||.|:|||||||.|:|
Zfish   732 VTQQLRARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	196..831	CDD:279260	428/634 (68%)
		CULLIN	582..724	CDD:214545	104/141 (74%)
		Cullin_Nedd8	866..926	CDD:287520	46/59 (78%)
cul3a	NP_955985.2	Cullin	41..670	CDD:279260	428/636 (67%)
		CULLIN	427..569	CDD:214545	104/141 (74%)
		Cullin_Nedd8	706..766	CDD:287520	46/59 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589984
Domainoid	1	1.000	851	1.000	Domainoid score	I58
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1026	1.000	Inparanoid score	I272
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0000491
OrthoInspector	1	1.000	-	-		otm24410
orthoMCL	1	0.900	-	-		OOG6_102066
Panther	1	1.100	-	-	O	PTHR11932
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2234
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770