DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul3 and cul1a

DIOPT Version :9

Sequence 1:	NP_723909.2	Gene:	Cul3 / 34896	FlyBaseID:	FBgn0261268	Length:	934	Species:	Drosophila melanogaster
Sequence 2:	NP_955953.2	Gene:	cul1a / 323883	ZFINID:	ZDB-GENE-030131-2603	Length:	777	Species:	Danio rerio

Alignment Length:	808	Identity:	253/808 - (31%)
Similarity:	408/808 - (50%)	Gaps:	109/808 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 VETIWASLKNAIQEIQKKNNSGLS-FEQLYRNAYNMVLHKH------------------------ 228
            ::.||..|:..||::..:.:...| :.:||.:.||.....|
Zfish    17 LDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQVRGGGPAPSKPSKKTPTPGG 81

  Fly   229 ----GNRLYYGLREVVSEHLEHKVRADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVY 289
                |..||..|:|.:..:|.:.:: |..:.:..:.|....|.|.|::.|..::..|..|::|.:
Zfish    82 AQFVGLELYKRLKEFLKNYLTNLLK-DGEDLMDESVLKFYTQQWEDYRFSSKVLNGICAYLNRHW 145

  Fly   290 VQQREVD-------NVYNLGLILFRDQVVRYSEIQKALREKLLGMVMEERHGEAINHLAIKNACS 347
            | :||.|       .:|:|.|:.:|:.:.|  .:.|.:...:|.::.:||:||.||...|.....
Zfish   146 V-RRECDEGRKGIYEIYSLALVTWRECLFR--PLNKQVTNAVLKLIEKERNGETINTRLISGVVQ 207

  Fly   348 MLITLGIN---------SRTVYEEDFEKPFLAQSAAFYKFESQNFLAENNAGVYIKKVEARITEE 403
            ..:.||:|         :.:||:|.||..|||.:..||..||..||.:|....|:||.|||:.||
Zfish   208 SYVELGLNEDDAFAKGPTLSVYKEYFETQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEE 272

  Fly   404 SSRAALYLDKDTEPRIVRVVEEELIKKHMRPI-VEMENSGVVYMIKNSKTEDLACTYKLFSRLKE 467
            ..|..:||.:.|:..:.|..|:.||:||:... .|.:|     ::...|.|||...|.|.||: .
Zfish   273 QRRVQVYLHESTQDELARKCEQVLIEKHLEIFHTEFQN-----LLDADKNEDLGRMYNLVSRI-T 331

  Fly   468 EGLKVIADTMSAYLREQGRMLVKE-EENGNTNPITFVQNLLDLKDRFDQFLVHSFANDRIFKNVI 531
            :||..:...:..::..||...::: .|:...:|..:||.:||:..:::..::.:|.||..|...:
Zfish   332 DGLGELKKLLETHIYNQGLAAIEKCGESALNDPKMYVQTILDVHKKYNALVMSAFNNDAGFVAAL 396

  Fly   532 SSDFEHFLNLN---------NKSPEYLSLFIDDKLKKGGKGMSEQEIESILDKTMVLFRFLLEKD 587
            ......|:|.|         :||||.|:.:.|..|||..|...|.|:|..|::.||:|:::.:||
Zfish   397 DKACGRFINNNAVTKMVQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKD 461

  Fly   588 VFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSVSNTIMDEFKNFV 652
            ||:::|...|||||:...|.|||.|.:||||||..||.::||||:.||:|:.||..:.::||..:
Zfish   462 VFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHL 526

  Fly   653 NNNN-LSLGGVELTVRILTTGFWPTQTATPNCN--IPAAPREAFDIFKNFYLNKHSGRQLTLQPQ 714
            .|:. |.|   :.::::|::|.||.|   .:|.  :|:....::..|..||.::||||:||
Zfish   527 TNSEPLDL---DFSIQVLSSGSWPFQ---QSCTFALPSELERSYQRFTAFYASRHSGRKLT---- 581

  Fly   715 MGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTYQMCVLLLFNNRDVLTYD 779
                ::..:..|.......|:                  ::.||.||:||.:||.:|..||.|..
Zfish   582 ----WLYHLSKGELVTNCFKN------------------RYTLQASTFQMAILLQYNTEDVYTVQ 624

  Fly   780 DIHQETDIPERELVRALQSLSMGKPAQRLLV---RNSKTKTKDIEPTDEFYVNDAFNSKFHRVKI 841
            .:...|.|....||:.||.|...|    |||   .|:.....:.:|.....:...:.:|..||.|
Zfish   625 QLTDSTQIKIDILVQVLQILLKSK----LLVLEDENANVDEVEFKPDTLIKLFLGYKNKKLRVNI 685

  Fly   842 QTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVF 906
             .|..|.|.:.|::.|...::||||..|:||||||||.||.|.|..|:::|.:||.|||.|....
Zfish   686 -NVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLAEVLNQLSSRFKPRVPV 749

  Fly   907 IKKRIEGLIEREYLQRSPEDRKVYNYLA 934
            |||.|:.|||:|||:|...::..|:|||
Zfish   750 IKKCIDILIEKEYLERVDGEKDTYSYLA 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	196..831	CDD:279260	202/696 (29%)
		CULLIN	582..724	CDD:214545	53/144 (37%)
		Cullin_Nedd8	866..926	CDD:287520	33/59 (56%)
cul1a	NP_955953.2	Cullin	22..661	CDD:307166	201/684 (29%)
cul1a	NP_955953.2	Cullin_Nedd8	704..771	CDD:214883	36/66 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.830