Protein Alignment Cul3 and Cul3

DIOPT Version :10

• Sequence 1: NP_723909.2
• Gene: Cul3 / 34896
• FlyBaseID: FBgn0261268
• Length: 934
• Species: Drosophila melanogaster
• Sequence 2: NP_001100393.2
• Gene: Cul3 / 301555
• RGDID: 1308190
• Length: 768
• Species: Rattus norvegicus
• Alignment Length: 759
• Identity: 528/759 - (69%)
• Similarity: 617/759 - (81%)
• Gaps: 11/759 - (1%)

  Fly   178 RAFNASMDEKYVETIWASLKNAIQEIQKKNNSGLSFEQLYRNAYNMVLHKHGNRLYYGLREVVSE 242
            |||..:||||||.:||..|||||||||:|||||||||:||||||.|||||||.:||.||||||:|
  Rat    19 RAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTE 83

  Fly   243 HLEHKVRADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQQREVDNVYNLGLILFR 307
            ||.:|||.|||.:|::|||..|||||.||||:||||||||||||||||||..|:||||||||:||
  Rat    84 HLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFR 148

  Fly   308 DQVVRYSEIQKALREKLLGMVMEERHGEAINHLAIKNACSMLITLGINSRTVYEEDFEKPFLAQS 372
            ||||||..|:..||:.||.|:..||.||.::..||:|||.||:.||:..|:|||||||.|||..|
  Rat   149 DQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMS 213

  Fly   373 AAFYKFESQNFLAENNAGVYIKKVEARITEESSRAALYLDKDTEPRIVRVVEEELIKKHMRPIVE 437
            |.|::.|||.|||||:|.||||||||||.||..|....|||.||..||:|||.|||.|||:.|||
  Rat   214 AEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVE 278

  Fly   438 MENSGVVYMIKNSKTEDLACTYKLFSRLKEEGLKVIADTMSAYLREQGRMLVKEEENGNTNPITF 502
            |||||:|:|:||.|||||||.||||||: ..|||.:.:.||:||||||:.||.||..|. ||:.:
  Rat   279 MENSGLVHMLKNGKTEDLACMYKLFSRV-PNGLKTMCECMSSYLREQGKALVSEEGEGK-NPVDY 341

  Fly   503 VQNLLDLKDRFDQFLVHSFANDRIFKNVISSDFEHFLNLNNKSPEYLSLFIDDKLKKGGKGMSEQ 567
            :|.|||||.|||:||..||.|||:||..|:.|||:|||||::||||||||||||||||.||::||
  Rat   342 IQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQ 406

  Fly   568 EIESILDKTMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLE 632
            |:|:||||.||||||:.||||||||||.|||:|||.|||||||.|||||||||||||||||||||
  Rat   407 EVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLE 471

  Fly   633 GMFKDMSVSNTIMDEFKNFVNNNNLSLGGVELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFK 697
            |||:|||:|||.||||:..:....:|||||:||||:||||:||||:|||.||||.|||.||:||:
  Rat   472 GMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFR 536

  Fly   698 NFYLNKHSGRQLTLQPQMGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVP-TTTRKHILQVST 761
            .|||.||||||||||..||:|.:||.|||     ..|.:|.......|..|. :.||||||||||
  Rat   537 RFYLAKHSGRQLTLQHHMGSADLNATFYG-----PVKKEDGSEVGVGGAQVTGSNTRKHILQVST 596

  Fly   762 YQMCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEF 826
            :||.:|:|||||:..|:::|.|||||||||||||||||:.|||.||:|.:  :.|:|:||....|
  Rat   597 FQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTK--EPKSKEIESGHIF 659

  Fly   827 YVNDAFNSKFHRVKIQTVAAK-GESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVS 890
            .|||.|.||.||||||||||| |||:|||||||.|||:|||||||||||||||:||::.||:||:
  Rat   660 TVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVA 724

  Fly   891 DVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934
            :||.|||:|||||||.||||||||||||||.|:|||||||.|:|
  Rat   725 EVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	193..832	CDD:459983	434/639 (68%)
		Cullin_Nedd8	864..926	CDD:463146	49/61 (80%)
Cul3	NP_001100393.2	Interaction with KLHL18. /evidence=ECO:0000250|UniProtKB:Q13618	2..41		14/21 (67%)
		Cullin	34..665	CDD:459983	430/631 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	677..698		18/21 (86%)
		Cullin_Nedd8	698..760	CDD:463146	49/61 (80%)