DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul3 and Cul3

DIOPT Version :9

Sequence 1:	NP_723909.2	Gene:	Cul3 / 34896	FlyBaseID:	FBgn0261268	Length:	934	Species:	Drosophila melanogaster
Sequence 2:	NP_057925.1	Gene:	Cul3 / 26554	MGIID:	1347360	Length:	768	Species:	Mus musculus

Alignment Length:	759	Identity:	528/759 - (69%)
Similarity:	616/759 - (81%)	Gaps:	11/759 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 RAFNASMDEKYVETIWASLKNAIQEIQKKNNSGLSFEQLYRNAYNMVLHKHGNRLYYGLREVVSE 242
            |||..:||||||.:||..|||||||||:|||||||||:||||||.|||||||.:||.||||||:|
Mouse    19 RAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTE 83

  Fly   243 HLEHKVRADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQQREVDNVYNLGLILFR 307
            ||.:|||.|||.:|::|||..|||||.||||:||||||||||||||||||..|:||||||||:||
Mouse    84 HLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFR 148

  Fly   308 DQVVRYSEIQKALREKLLGMVMEERHGEAINHLAIKNACSMLITLGINSRTVYEEDFEKPFLAQS 372
            ||||||..|:..||:.||.|:..||.||.::..||:|||.||:.||:..|:|||||||.|||..|
Mouse   149 DQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMS 213

  Fly   373 AAFYKFESQNFLAENNAGVYIKKVEARITEESSRAALYLDKDTEPRIVRVVEEELIKKHMRPIVE 437
            |.|::.|||.|||||:|.||||||||||.||..|....|||.||..||:|||.|||.|||:.|||
Mouse   214 AEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVE 278

  Fly   438 MENSGVVYMIKNSKTEDLACTYKLFSRLKEEGLKVIADTMSAYLREQGRMLVKEEENGNTNPITF 502
            |||||:|:|:||.|||||||.||||||: ..|||.:.:.||.||||||:.||.||..|. ||:.:
Mouse   279 MENSGLVHMLKNGKTEDLACMYKLFSRV-PNGLKTMCECMSCYLREQGKALVSEEGEGK-NPVDY 341

  Fly   503 VQNLLDLKDRFDQFLVHSFANDRIFKNVISSDFEHFLNLNNKSPEYLSLFIDDKLKKGGKGMSEQ 567
            :|.|||||.|||:||..||.|||:||..|:.|||:|||||::||||||||||||||||.||::||
Mouse   342 IQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQ 406

  Fly   568 EIESILDKTMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLE 632
            |:|:||||.||||||:.||||||||||.|||:|||.|||||||.|||||||||||||||||||||
Mouse   407 EVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLE 471

  Fly   633 GMFKDMSVSNTIMDEFKNFVNNNNLSLGGVELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFK 697
            |||:|||:|||.||||:..:....:|||||:||||:||||:||||:|||.||||.|||.||:||:
Mouse   472 GMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFR 536

  Fly   698 NFYLNKHSGRQLTLQPQMGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVP-TTTRKHILQVST 761
            .|||.||||||||||..||:|.:||.|||     ..|.:|.......|..|. :.||||||||||
Mouse   537 RFYLAKHSGRQLTLQHHMGSADLNATFYG-----PVKKEDGSEVGVGGAQVTGSNTRKHILQVST 596

  Fly   762 YQMCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEF 826
            :||.:|:|||||:..|:::|.|||||||||||||||||:.|||.||:|.:  :.|:|:||....|
Mouse   597 FQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTK--EPKSKEIESGHIF 659

  Fly   827 YVNDAFNSKFHRVKIQTVAAK-GESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVS 890
            .|||.|.||.||||||||||| |||:|||||||.|||:|||||||||||||||:||::.||:||:
Mouse   660 TVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVA 724

  Fly   891 DVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934
            :||.|||:|||||||.||||||||||||||.|:|||||||.|:|
Mouse   725 EVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	196..831	CDD:279260	432/635 (68%)
		CULLIN	582..724	CDD:214545	107/141 (76%)
		Cullin_Nedd8	866..926	CDD:287520	47/59 (80%)
Cul3	NP_057925.1	Interaction with KLHL18. /evidence=ECO:0000250\|UniProtKB:Q13618	2..41		14/21 (67%)
		Cullin	35..664	CDD:279260	429/629 (68%)
		CULLIN	421..563	CDD:214545	107/141 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	677..698		18/21 (86%)
		Cullin_Nedd8	700..760	CDD:287520	47/59 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845417
Domainoid	1	1.000	833	1.000	Domainoid score	I58
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2661
Inparanoid	1	1.050	1029	1.000	Inparanoid score	I272
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000491
OrthoInspector	1	1.000	-	-		oto94368
orthoMCL	1	0.900	-	-		OOG6_102066
Panther	1	1.100	-	-	LDO	PTHR11932
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R263
SonicParanoid	1	1.000	-	-		X2234
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790