Protein Alignment Cul3 and cul4

DIOPT Version :10

• Sequence 1: NP_723909.2
• Gene: Cul3 / 34896
• FlyBaseID: FBgn0261268
• Length: 934
• Species: Drosophila melanogaster
• Sequence 2: NP_594195.1
• Gene: cul4 / 2543116
• PomBaseID: SPAC3A11.08
• Length: 734
• Species: Schizosaccharomyces pombe
• Alignment Length: 797
• Identity: 212/797 - (26%)
• Similarity: 364/797 - (45%)
• Gaps: 102/797 - (12%)

  Fly   173 PEYKR---RAF----NASMDEKYVETIWASLKNAIQEIQKKNNSGLSFEQLYRNAYNMVLHKHGN 230
            ||.||   :.|    :....|.|..|:...|..|:|.:.........:::||....|:......:
pombe     3 PEAKRIVVKGFDPRKSRQRQETYYVTMIDRLNMALQVVMAGLGLKTGYQELYSGVENLTRADQAS 67

  Fly   231 RLYYGLREVVSEHLEHKVRADVLEALHSNFLPKLNQAWTDHQTSMV-------------MIRDIL 282
            |.:    .::..|:...::  :|:....:|: :|....||.....|             ::::|.
pombe    68 RCF----NILQHHMSSGIQ--LLKDSAESFI-QLEGTETDTNACTVVVGCWNKWLERVEIVQNIF 125

  Fly   283 MYMDRVYVQQR-EVDNVYNLGLILFRDQVVRYSEIQKALREKLLGMVMEERHGEAINHLAIKNAC 346
            .|||:.::... :...:..|.|.|||::::....||......||.........::.:|..:::|.
pombe   126 YYMDKTFLSHHPDYPTIEELSLSLFREKLMAVKNIQIPFLNSLLQSFENLHSSKSTDHAYLQDAM 190

  Fly   347 SMLITLGINSRT-VYEEDFEKPFLAQSAAFYKFESQNFLAENNAGVYIKKVEARITEESSRAALY 410
            .||      .|| :|...|...:|...:.||..||...:.|.....|::...:.:..|.:    |
pombe   191 LML------HRTEMYSSVFVPMYLVMLSRFYDTESSQKIQELPLEEYLEYAMSSLEREDA----Y 245

  Fly   411 LDK----DTEPRIVRVVEEELIKKHMRPIVEMENSGVVYMIKNSKTEDLACTYKLFSRLKEEGLK 471
            ::|    ..:..|...|:..||..|:..:.:    |:...|:..........|.|.....|  .:
pombe   246 VEKFDIVRDKKSIRETVQRCLITSHLDTLTK----GISQFIEKRDAHSCKLLYALLQFNHE--TE 304

  Fly   472 VIADTMSAYLREQGRMLVKEEENGNTNPITFVQNLLDLKDRFDQFLV-HSFANDRIFKNVISSDF 535
            .:....|..|.:.|..||.:|...:    |.||.||.. .:|.|.:| .||.:|......:...|
pombe   305 YLIQPWSDCLVDVGFKLVNDESKDD----TLVQELLSF-HKFLQVVVDESFLHDETLSYAMRKAF 364

  Fly   536 EHFLN----LNNKSP-EYLSLFIDDKLKKGGKGMSEQEIESILDKTMVLFRFLLEKDVFERYYKT 595
            |.|:|    ...::| ..::.:||..|:.|.:....:.::.:..:.:.|||::..||:||.|||.
pombe   365 ETFINGAKGSQREAPARLIAKYIDYLLRVGEQASGGKPLKEVFSEILDLFRYIASKDIFEAYYKL 429

  Fly   596 HLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSVSNTIMDEFKNFVNNNNLSLG 660
            .:|||||||||.|...|..::..||..||.|||..|||||:|:::|......|::....:||..
pombe   430 DIAKRLLLNKSASAQNELMLLDMLKKTCGSQFTHSLEGMFRDVNISKEFTSSFRHSKAAHNLHR- 493

  Fly   661 GVELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFKNFYLNKHSGRQLTLQPQMGTAYINAVF- 724
              :|.|.:|:..:||:...: :..:|...::..|.|:.|||:|..|::::....:|...:.|.|
pombe   494 --DLYVNVLSQAYWPSYPES-HIRLPDDMQQDLDCFEKFYLSKQVGKKISWYASLGHCIVKARFP 555

  Fly   725 YGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTYQMCVLLLFNN---RDVLTYDDIHQETD 786
            .|.|.                           |.:|.:|.||||.|||   .:.::|.|:.:.|:
pombe   556 LGNKE---------------------------LSISLFQACVLLQFNNCLGGEGISYQDLKKSTE 593

  Fly   787 IPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVNDAFNSKFHRVKIQTVAAKGESE 851
            :.:.:|.|.|||||..:....::|    .|:|...|...||||:.|..|.:||||..:..| |..
pombe   594 LSDIDLTRTLQSLSCARIRPLVMV----PKSKKPSPDTMFYVNEKFTDKLYRVKINQIYLK-EER 653

  Fly   852 PERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEGLIE 916
            .|..:.:.:|..||:.|::|:|||:||.::::.|:.||..|.:.:|.|.:|....:|..||.|:|
pombe   654 QENSDVQEQVVRDRQFELQASIVRVMKQKEKMKHDDLVQYVINNVKDRGIPLVSDVKTAIEKLLE 718

  Fly   917 REYLQRSPEDRKVYNYL 933
            :|||:|  ||..:|.|:
pombe   719 KEYLER--EDNDIYTYV 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	193..832	CDD:459983	165/667 (25%)
		Cullin_Nedd8	864..926	CDD:463146	25/61 (41%)
cul4	NP_594195.1	COG5647	1..734	CDD:227934	212/797 (27%)