Protein Alignment Cul3 and cul3

DIOPT Version :10

• Sequence 1: NP_723909.2
• Gene: Cul3 / 34896
• FlyBaseID: FBgn0261268
• Length: 934
• Species: Drosophila melanogaster
• Sequence 2: NP_592949.1
• Gene: cul3 / 2542637
• PomBaseID: SPAC24H6.03
• Length: 785
• Species: Schizosaccharomyces pombe
• Alignment Length: 811
• Identity: 307/811 - (37%)
• Similarity: 443/811 - (54%)
• Gaps: 92/811 - (11%)

  Fly   178 RAFNASMDEKYVETIWASLKNAIQEIQKKNNSGLSFEQLYRNAYNMVLHKHGNRLYYGLREVVSE 242
            |.|:|:..:  ..|.|..|:.||.:|.:|:.|.||||:||||||.:||||:|.:||..:::|:..
pombe    13 RKFSANQVD--FATHWEVLQRAIGDIFQKSTSQLSFEELYRNAYILVLHKYGEKLYNHVQDVIRS 75

  Fly   243 HL-EHKVRA---------------DV-------------LEALHSNFLPKLNQAWTDHQTSMVMI 278
            .| |..|.|               |:             |||.| .||..|..:|.||..||.||
pombe    76 RLKEETVPAIYKNYDASLLGNALLDIRKNDSYSTSWSRSLEAAH-RFLSSLVNSWKDHIVSMQMI 139

  Fly   279 RDILMYMDRVYVQQREVDNVYNLGLILFRDQVVRYS-EIQKALREKLLGMVMEERHGEAINHLAI 342
            ..:|.|:|:||.:..:...|...|:.:||:.|:..| ||.:...|.:|.:|..||.|..||...|
pombe   140 SSVLKYLDKVYSKSADKVPVNENGIYIFREVVLLNSFEIGEKCVETILILVYLERKGNTINRPLI 204

  Fly   343 KNACSMLITLGINSR--TVYEEDFEKPFLAQSAAFYKFESQNFLAENNAGVYIKKVEARITEESS 405
            .:...||.:|...::  |:|:..|...||:.:..||:.||...:.......|:||.|.|..||..
pombe   205 NDCLDMLNSLPSENKKETLYDVLFAPKFLSYTRNFYEIESSTVIGVFGVVEYLKKAEKRFEEEKE 269

  Fly   406 RAALYLDKDTEPRIVRVVEEELIKKHMRPIVEMENSGVVYMIKNSKTEDLACTYKLFSRLKEEGL 470
            |:..||.......::.|||:||:.||:..::|.:::|...||.:|..|.|...|:.|||: |.|:
pombe   270 RSKNYLFTKIASPLLSVVEDELLSKHLDDLLENQSTGFFSMIDSSNFEGLQLVYESFSRV-ELGV 333

  Fly   471 KVIADTMSAYLRE-------------QGRMLVKEEENGNTNPITFVQNLLDLKDRFDQFLVHSFA 522
            |.:...::.|:..             :|:|.|....:..|....:||.:|.|.||.:..:..:..
pombe   334 KSLKKYLAKYVAHHGKLINETTSQALEGKMAVGRLSSNATMATLWVQKVLALWDRLNTIISTTMD 398

  Fly   523 NDRIFKNVISSDFEHFLNLNNKSPEYLSLFIDDKLKKGGKGMSEQEIESILDKTMVLFRFLLEKD 587
            .||...|.:|..|..|::...::|||:||||||.|||..:...|..||:.|..::.||||:.|||
pombe   399 ADRSILNSLSDAFVTFVDGYTRAPEYISLFIDDNLKKDARKAIEGSIEATLQNSVTLFRFISEKD 463

  Fly   588 VFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSVSNTIMDEFKNFV 652
            |||:|||||||||||.|:|:|.|.|..|||:||.|.|..||.||||||.||::|..::.|:|
pombe   464 VFEKYYKTHLAKRLLNNRSISSDAELGMISRLKQEAGNVFTQKLEGMFNDMNLSQELLQEYK--- 525

  Fly   653 NNNNLSLG--GVELTVRILTTGFWPTQTATPN---CNIPAAPREAFDIFKNFYLNKHSGRQLTLQ 712
            :|:.|...  .::|.|.||.:.|||.. .:|:   ||.|.......|.|.:|||:||:||:|...
pombe   526 HNSALQSAKPALDLNVSILASTFWPID-LSPHKIKCNFPKVLLAQIDQFTDFYLSKHTGRKLLWY 589

  Fly   713 PQMGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTYQMCVLLLFNN---RD 774
            |.||:|.:...|           ||               ||:.|.|||....:||||.:   ..
pombe   590 PSMGSADVRVNF-----------KD---------------RKYDLNVSTIASVILLLFQDLKENQ 628

  Fly   775 VLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVNDAFNSKFHRV 839
            .|.:::|.::|:|...:|.|.||||:..|  .::|:::  .|.:::...|:||.|:.|.|...|:
pombe   629 CLIFEEILEKTNIEVGDLKRNLQSLACAK--YKILLKD--PKGREVNAGDKFYFNENFVSNLARI 689

  Fly   840 KIQTVA-AKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPS 903
            ||.||| .:.|.:.|||.|..||||.|||:.:|.|||:||.||...||.|:::||.||..||.||
pombe   690 KISTVAQTRVEDDSERKRTLEKVDESRKHQADACIVRVMKDRKVCEHNQLMAEVTRQLNPRFHPS 754

  Fly   904 PVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934
            |:.||:|||.|||||||||..::.::|.|||
pombe   755 PMMIKRRIEALIEREYLQRQADNGRIYEYLA 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	193..832	CDD:459983	245/691 (35%)
		Cullin_Nedd8	864..926	CDD:463146	37/61 (61%)
cul3	NP_592949.1	COG5647	1..785	CDD:227934	305/809 (38%)