Protein Alignment Cul3 and cul1

DIOPT Version :10

• Sequence 1: NP_723909.2
• Gene: Cul3 / 34896
• FlyBaseID: FBgn0261268
• Length: 934
• Species: Drosophila melanogaster
• Sequence 2: NP_594259.1
• Gene: cul1 / 2542393
• PomBaseID: SPAC17G6.12
• Length: 767
• Species: Schizosaccharomyces pombe
• Alignment Length: 795
• Identity: 220/795 - (27%)
• Similarity: 377/795 - (47%)
• Gaps: 88/795 - (11%)

  Fly   186 EKY--VETIWASLKNAIQEIQKKNNSGLS---FEQLYRNAYN----------------MVLHKHG 229
            :||  :...|..||..:.:|.::.:.|::   :.:||...:|                ...:..|
pombe    15 KKYDSLNGTWDFLKTGVSQIFERLDEGMTITKYMELYTAIHNYCADASKTITVDNFNDQTANVLG 79

  Fly   230 NRLYYGLREVVSEHLEHKVRADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQQRE 294
            ..||..|...:.|:|....:..:.:..|...|....:.||...||...|..:..|::|.:|:.:.
pombe    80 EALYNNLVLYLEEYLARLRKECISQTNHEEQLAAYAKYWTRFTTSARFINHLFGYLNRYWVKLKN 144

  Fly   295 ------VDNVYNLGLILFRDQVVRYSEIQKALREKLLGMVMEERHGEAINHLAIKNACSMLITLG 353
                  |.::|.|.|:.:...|  :|.|:.:|.:.||.|..::|..|..:...::.....:.:|.
pombe   145 RFTETLVYDIYTLCLVSWHHHV--FSHIRDSLLQNLLYMFTKKRLYEPTDMKYVEVCVDSITSLS 207

  Fly   354 INSRTV-------YEEDFEKPFLAQSAAFYKFESQNFLAENNAGVYIKKVEARITEESSRAALYL 411
            .:...:       |:..||..|:..:..||..||..:||.::...|:||.|.|:.||.....|||
pombe   208 FDKTDMTKPNLSSYKTFFETNFIENTKNFYAKESSEYLASHSITDYLKKAEIRLAEEEELVRLYL 272

  Fly   412 DKDTEPRIVRVVEEELIKKHMRPIVEMENSGVVYMIKNSKTEDLACTYKLFSRLKEEGLKVIADT 476
            .:.|...::...|:.||.:|    .|:.::....|:..:.:||:...|:|.|| ...||:.:..|
pombe   273 HESTLKPLLEATEDVLIAQH----EEVLHNDFARMLDQNCSEDIIRMYRLMSR-TPNGLQPLRQT 332

  Fly   477 MSAYLREQG-----RMLVKEEENGNTNPITFVQNLLDLKDRFDQFLVHSFANDRIFKNVISSDFE 536
            ...:::..|     :::.:.....:.:|..:::.||.......:.:..:|..|..|...:.:.|.
pombe   333 FEEFVKRSGFAAVAKIVPQVGGEADVDPKEYMEMLLSTYKASKELVNTAFHGDTDFTKSLDTAFR 397

  Fly   537 HFLNLN-------NKSPEYLSLFIDDKLKKGGKGMSEQEIESILDKTMVLFRFLLEKDVFERYYK 594
            ..:|.|       ::|||.|:.:.|..|:|..|.:...::|..|...:::||::.:||||:.:|.
pombe   398 ELVNRNVVCQRSSSRSPELLAKYADSILRKSNKNVDIDDVEDCLSSIIIIFRYVEDKDVFQNFYT 462

  Fly   595 THLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSVSNTIMDEFKNFVNNNNLSL 659
            ..|||||:...|.|.|.|.:|:||||..||.::||||:.||:|:|:|..|.:.|.....:.   .
pombe   463 KLLAKRLVNGTSNSQDAESSMLSKLKEVCGFEYTSKLQRMFQDISLSQEITEAFWQLPQSR---A 524

  Fly   660 GGVELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFKNFYLNKHSGRQLTLQPQMGTAYINAVF 724
            |.::.:..:|.|.|||......|.::|......::.|:|:|.:.|:||:|:....:....|.|..
pombe   525 GNIDFSALVLGTSFWPLSPNNVNFHLPEELVPLYEGFQNYYYSCHNGRKLSWLFHLSKGEIKARI 589

  Fly   725 YGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTYQMCVLLLFNNRDVLTYDDIHQETDIPE 789
            .                       |.|...::.|||||||.||||:|:||..||:::.:.|.:..
pombe   590 N-----------------------PQTNVTYVFQVSTYQMGVLLLYNHRDSYTYEELAKITGLST 631

  Fly   790 RELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVNDAFNSKFHRVKIQTVAAKGESEPER 854
            ..|...|......|    :|:.....|..|  |...:.:|:.|..|..||:: .:..:.|.:.|.
pombe   632 DFLTGILNIFLKAK----VLLLGDNDKLGD--PNSTYKINENFRMKKIRVQL-NLPIRSEQKQES 689

  Fly   855 KETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREY 919
            .||...::||||..:::|||||||||:.|.|.:||.:...|:||||.|....||:.|:.|||:||
pombe   690 LETHKTIEEDRKLLLQSAIVRIMKARRTLKHVVLVKETIDQIKSRFTPKVSDIKQCIDMLIEKEY 754

  Fly   920 LQRSPEDRKVYNYLA 934
            |:|...|.  |.|||
pombe   755 LERQGRDE--YIYLA 767

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	193..832	CDD:459983	172/682 (25%)
		Cullin_Nedd8	864..926	CDD:463146	32/61 (52%)
cul1	NP_594259.1	COG5647	1..767	CDD:227934	218/793 (27%)