DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul3 and cul-5

DIOPT Version :9

Sequence 1:	NP_723909.2	Gene:	Cul3 / 34896	FlyBaseID:	FBgn0261268	Length:	934	Species:	Drosophila melanogaster
Sequence 2:	NP_505616.2	Gene:	cul-5 / 179413	WormBaseID:	WBGene00000840	Length:	765	Species:	Caenorhabditis elegans

Alignment Length:	830	Identity:	200/830 - (24%)
Similarity:	366/830 - (44%)	Gaps:	171/830 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 LSFEQLYRNA---YNMVLHKHG------NRLYYGLREVVS--EHLEHKVRADVLEALHSNFLPKL 264
            :.|::.:..|   .:.:||:..      ..|:|.:.::.|  :....|:| |:|....::::.:.
Worm     1 MQFDEEWSKADPIVHALLHQKSVTPAAWQDLFYHVYKITSWVDDGPLKIR-DILTRCINDYVHEA 64

  Fly   265 NQAWTDHQTSMVMIRDILMYMDRVYVQ----------------QREVDNVYNLGL---ILFRDQV 310
            |:.....||...::...:...:|.|.|                :|.|.......:   :|.:...
Worm    65 NKRIRSLQTDGSLLIGYIKEWNRFYQQANILPLPFKKIDESSRRRSVPETPEESIRTVMLEKWNE 129

  Fly   311 VRYSEIQKALREKLLGMVMEERHG---EAINHLAIKNACSMLITLGINSRT------VYEEDFEK 366
            :.:..|.:.|..:.|.:|.|||.|   :|.|.:.|:.:     .:.:|.|.      ||.:.||:
Worm   130 IIFMNISEQLLVEALRLVKEERDGNIIDAQNVIGIRES-----FVALNDRAGEDPLLVYRQSFER 189

  Fly   367 PFLAQSAAFYKFESQNFLAENNAGVYIKKVEARITEESSRAALYLD-------KDTEPRIVRVVE 424
            .|:.|:..:||....|.|.|.....|:...:.::.||..||..||:       |..|..::.:||
Worm   190 QFIEQTTEYYKKICGNLLNELGVLEYMVYADKKLEEEQQRAKRYLEMNSPTSGKHMEKAVIALVE 254

  Fly   425 --EELIKKHMRPIVEMENSGVVYMIKNSKTEDLACTYKLFSRLKEEGLKVIADTMSAYLREQG-R 486
              |:.|      :.|...     :|.:...|.|...|:|..|.: .|:..:...:..::|.:| .
Worm   255 SFEDTI------LAECSK-----LIASKDVERLQRLYRLIRRTR-SGIDTVLKCIDTHIRTEGLN 307

  Fly   487 MLVKEEENGNTNPITFVQNLLDLKDRFDQFLVHSF--------ANDRIFKNVI--SSDFE----- 536
            .:....||.:|:|..:||.||.:.|:|...:...|        |.|:.|:.|:  ||.|:
Worm   308 DMRNNAENLSTDPERYVQQLLLMFDKFSSLVREGFCDDARLLTARDKAFRAVVNDSSIFKTEMMN 372

  Fly   537 ---HFLNLNNKSPEYLSLFIDDKLKKG--GKGMSEQEIESILDKTMVLFRFLLEKDVFERYYKTH 596
               ..|::.:|..|.|:.:.|..|:|.  .|.::.:||:..|::.:::.:::..||||.|:::.|
Worm   373 KKGRTLSVESKCAELLANYCDLLLRKTQLSKKLTSEEIDEKLNQVLLVLKYVENKDVFMRFHRAH 437

  Fly   597 LAKRLLLNKSVSDDFEKNMISKLKTECG--CQFTSKLEGMFKDMSVSNTIMDEFKNFV--NNNNL 657
            |::||:|..|...:.|:.|::||: |||  ....:||..|.:|:.::..:...||..:  .|||.
Worm   438 LSRRLILEMSADQEKEEMMVTKLR-ECGMPSDAVNKLSRMLQDIELNKDMNSSFKKALTGTNNNK 501

  Fly   658 SLGGVELTVRILTTGFWPTQTATPNCNIPAAPREAFDI---FKNFYLNKHSGRQLTLQPQMGTAY 719
            |:.. .:.:::|..|.| .:..:..... :.|||..|.   .:.||..:|:||:|......
Worm   502 SIAD-SINMKVLNGGAW-GRGGSERIRF-SLPRELEDFVPEMEAFYKKQHNGRKLCWMHHW---- 559

  Fly   720 INAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTR--KHILQVSTYQMCVLLLFNNR--DVLTYDD 780
                                   |||..|..|..  :..|:.:|:||.||..||:|  |.::.:.
Worm   560 -----------------------SSGTMVFGTANGGRFDLECTTFQMAVLFCFNDRAHDKISLET 601

  Fly   781 IHQETDIPERELVRALQSLSMGKPAQR---LL--VRNSKTKTKDIEPTDEFYVNDAFNSKFHRVK 840
            :...|::|:.||.|.|.|| :..|..|   ||  |.::....:|...:.:|.:|..||
Worm   602 LRLATELPDAELNRTLLSL-VAYPKMRYQILLCDVPSTTVTARDFTDSTKFLINHDFN------- 658

  Fly   841 IQTVAAKGESEPERKETRGKV------------DEDRKHE---------IEAAIVRIMKARKRLA 884
               |...|:|     :.||||            :.:::||         ::..||:|:|.||...
Worm   659 ---VVKNGKS-----QQRGKVNLIGRLQLSLEANAEKEHESIVALRELRVQEGIVKILKTRKTYT 715

  Fly   885 HNLLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934
            ...|..::...||..|:|:...||::|:.|||.:|::|..:|...:.|::
Worm   716 LAQLTMELVEILKPLFIPNRKIIKEQIDWLIENKYMERRADDINTFVYIS 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	196..831	CDD:279260	168/704 (24%)
		CULLIN	582..724	CDD:214545	41/148 (28%)
		Cullin_Nedd8	866..926	CDD:287520	21/68 (31%)
cul-5	NP_505616.2	Cullin	18..656	CDD:279260	166/687 (24%)
		CULLIN	423..562	CDD:214545	42/169 (25%)
		Cullin_Nedd8	692..759	CDD:214883	20/66 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820