DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul3 and cul-3

DIOPT Version :9

Sequence 1:	NP_723909.2	Gene:	Cul3 / 34896	FlyBaseID:	FBgn0261268	Length:	934	Species:	Drosophila melanogaster
Sequence 2:	NP_503151.1	Gene:	cul-3 / 178547	WormBaseID:	WBGene00000838	Length:	777	Species:	Caenorhabditis elegans

Alignment Length:	771	Identity:	374/771 - (48%)
Similarity:	531/771 - (68%)	Gaps:	23/771 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 RAFNASMDEKYVETIWASLKNAIQEIQKKNNSGLSFEQLYRNAYNMVLHKHGNRLYYGLREVVSE 242
            |.|.|::||:||...|..||.||||||:|||||||||:||||||.|||||||.|||.||::|:.:
Worm    16 RPFMATIDEQYVTQTWELLKRAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGERLYNGLKDVIQD 80

  Fly   243 HLEHKVRADVLEALHS-NFLPKLNQAWTDHQTSMVMIRDILMYMDRVYV-QQREVDNVYNLGLIL 305
            |:. .||..::|:::| :||..:.::|.||..:|||||||||||||:|| |...|..||||||..
Worm    81 HMA-SVRIRIIESMNSGSFLETVAESWADHTVAMVMIRDILMYMDRIYVAQNNHVLPVYNLGLDA 144

  Fly   306 FRDQVVRYSEIQKALREKLLGMVMEERHGEAINHLAIKNACSMLITLGINSRTVYEEDFEKPFLA 370
            :|.:::|.:.|...:|:.||.::..:|....||...|||||.|||:|||:||||||::||:|.|.
Worm   145 YRTEILRQNGIGDRIRDALLELIKLDRKSNQINWHGIKNACDMLISLGIDSRTVYEDEFERPLLK 209

  Fly   371 QSAAFYKFESQNFLA-ENNAGVYIKKVEARITEESSRAALYLDKDTEPRIVRVVEEELIKKHMRP 434
            :::.:|:...:|:|: :|:|..|:.:||..:.:|:|||:.||||.||.:|::|:::.::.:|::.
Worm   210 ETSDYYRDVCKNWLSGDNDACFYLAQVEIAMHDEASRASRYLDKMTEAKILQVMDDVMVAEHIQT 274

  Fly   435 IVEMENSGVVYMIKNSKTEDLACTYKLFSRLKEE------GLKVIADTMSAYLREQGRMLVKEEE 493
            ||.|:|.||.:|:::.|.|||...:::|.|:.:.      |||.:...:|.||.|.|..:||.|:
Worm   275 IVYMQNGGVKFMLEHKKIEDLTRIFRIFKRIGDSVTVPGGGLKALLKAVSEYLNETGSNIVKNED 339

  Fly   494 NGNTNPITFVQNLLDLKDRFDQFLVHSFANDRIFKNVISSDFEHFLNLNNKSPEYLSLFIDDKLK 558
            . ..||:.||..||.|||.|...|..:||:||.|||....|||.|||.|.:|||:::|::||.|:
Worm   340 L-LKNPVNFVNELLQLKDYFSSLLTTAFADDRDFKNRFQHDFETFLNSNRQSPEFVALYMDDMLR 403

  Fly   559 KGGKGMSEQEIESILDKTMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTEC 623
            .|.|.:|:.|:::.||..|:|||:|.||||||:|:|.:|||||||:||.|||.||.:::||||||
Worm   404 SGLKCVSDAEMDNKLDNVMILFRYLQEKDVFEKYFKQYLAKRLLLDKSCSDDVEKALLAKLKTEC 468

  Fly   624 GCQFTSKLEGMFKDMSVSNTIMDEFKNFVNNNNLSLGGVELTVRILTTGFWPTQTATPNCNIPAA 688
            |||||.|||.||:|..:..|:...|:::.......: .:::::|:||.|.||    |..||....
Worm   469 GCQFTQKLENMFRDKELWLTLATSFRDWREAQPTKM-SIDISLRVLTAGVWP----TVQCNPVVL 528

  Fly   689 PRE---AFDIFKNFYLNKHSGRQLTLQPQMGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPT 750
            |:|   |:::|..:|..||:||:||:...:|.|.:.|.||.........:::.|..||||..:..
Worm   529 PQELSVAYEMFTQYYTEKHTGRKLTINTLLGNADVKATFYPPPKASMSNEENGPGPSSSGESMKE 593

  Fly   751 TTRKH-ILQVSTYQMCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSK 814
            ...:| ||||:|:||.:||.||:.:.::...:..|..||||||.|.||||::||.:||:|||  |
Worm   594 RKPEHKILQVNTHQMIILLQFNHHNRISCQQLMDELKIPERELKRNLQSLALGKASQRILVR--K 656

  Fly   815 TKTKD-IEPTDEFYVNDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMK 878
            .|.|| |:.:|||.|||.|.||..|||:|.|..|.|||||.:|||.||::|||.|:|||||||||
Worm   657 NKGKDAIDMSDEFAVNDNFQSKLTRVKVQMVTGKVESEPEIRETRQKVEDDRKLEVEAAIVRIMK 721

  Fly   879 ARKRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934
            |||:|.||.||::||.||:.||:|||:.||:|||.|||||||.|...|.:.|.|:|
Worm   722 ARKKLNHNNLVAEVTQQLRHRFMPSPIIIKQRIETLIEREYLARDEHDHRAYQYIA 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	196..831	CDD:279260	299/648 (46%)
		CULLIN	582..724	CDD:214545	65/144 (45%)
		Cullin_Nedd8	866..926	CDD:287520	41/59 (69%)
cul-3	NP_503151.1	Cullin	32..674	CDD:279260	299/650 (46%)
		CULLIN	427..567	CDD:214545	65/144 (45%)
		Cullin_Nedd8	709..769	CDD:287520	41/59 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163597
Domainoid	1	1.000	563	1.000	Domainoid score	I114
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2661
Inparanoid	1	1.050	703	1.000	Inparanoid score	I343
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0000491
OrthoInspector	1	1.000	-	-		oto17195
orthoMCL	1	0.900	-	-		OOG6_102066
Panther	1	1.100	-	-	LDO	PTHR11932
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R263
SonicParanoid	1	1.000	-	-		X2234
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.840