Protein Alignment Cul3 and cul-1

DIOPT Version :10

• Sequence 1: NP_723909.2
• Gene: Cul3 / 34896
• FlyBaseID: FBgn0261268
• Length: 934
• Species: Drosophila melanogaster
• Sequence 2: NP_499309.1
• Gene: cul-1 / 176466
• WormBaseID: WBGene00000836
• Length: 780
• Species: Caenorhabditis elegans
• Alignment Length: 820
• Identity: 222/820 - (27%)
• Similarity: 379/820 - (46%)
• Gaps: 128/820 - (15%)

  Fly   190 ETIWASLKNAIQ-EIQKKNNSGLSFEQLYRNAY----NMVLHKH--------------------- 228
            |.:|..|::.:. ..:::|.:...:..||.:.|    ::.|...
 Worm    14 EVVWKKLQDGLDVAYRRENMAPKDYMTLYTSVYDYCTSITLSTSRRDGEDGRAESSTPARTAGAD 78

  Fly   229 --GNRLYYGLREVVSEHLEHKVRADVL-------EALHSNFLPKLNQAWTDHQTSMVMIRDILMY 284
              |:.:|        :.:|..|:|.|:       |....:.|......|.:.:.|..::..|..|
 Worm    79 FVGHEMY--------QRVEEYVKAYVIAVCEKGAELSGEDLLKYYTTEWENFRISSKVMDGIFAY 135

  Fly   285 MDRVYVQQREVDN-------VYNLGLILFRDQVVRYSEIQKALREKLLGMVMEERHGEAINHLAI 342
            ::|.:: :||:|.       ||.|.|::::..:  :::::..:.:.:|.::..||.|..||...|
 Worm   136 LNRHWI-RRELDEGHENIYMVYTLALVVWKRNL--FNDLKDKVIDAMLELIRSERTGSMINSRYI 197

  Fly   343 KNACSMLITLGI-NSRT------------VYEEDFEKPFLAQSAAFYKFESQNFLAE-NNAGVYI 393
            ......|:.||: :|.|            ||:|.||..||..:..||..|:.|||:. .|...|:
 Worm   198 SGVVECLVELGVDDSETDAKKDAETKKLAVYKEFFEVKFLEATRGFYTQEAANFLSNGGNVTDYM 262

  Fly   394 KKVEARITEESSRAALYLDKDTEPRIVRVVEEELIKKHMRPIVEMENSGVVYMIKNSKTEDLACT 458
            .|||.|:.:|..|..|||:..|:..:....|..||...: ..::....|   ::.:.:.:||:..
 Worm   263 IKVETRLNQEDDRCQLYLNSSTKTPLATCCESVLISNQL-DFLQRHFGG---LLVDKRDDDLSRM 323

  Fly   459 YKLFSRLKEEGLKVIADTMSAYLREQG-RMLVKEEENGNTNPITFVQNLLDLKDRFDQFLVHSFA 522
            :||..|: ..||..:..::..::.::| :.|.:......|:...:|:.||::.:|:...:..||.
 Worm   324 FKLCDRV-PNGLDELRKSLENHIAKEGHQALERVAMEAATDAKLYVKTLLEVHERYQSLVNRSFK 387

  Fly   523 NDRIFKNVISSDFEHFLNLN------------NKSPEYLSLFIDDKLKKGGKGMSEQEIESILDK 575
            |:..|...:......|:|.|            .||.|.|:.:.|..|:|..|...|.|:|.:..|
 Worm   388 NEPGFMQSLDKAATSFINNNAVTKRAPPQAQLTKSAELLARYCDQLLRKSSKMPDEAELEELQTK 452

  Fly   576 TMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSV 640
            .||:|:::.:||||.::|....:|||:...|.||:.|.|.|:|||:.||.::|::|..|..|..|
 Worm   453 IMVVFKYIDDKDVFSKFYTKMFSKRLISELSASDEAEANFITKLKSMCGYEYTARLSKMVNDTQV 517

  Fly   641 SNTIMDEFKNFVNNNNLSLGGVELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFKNFYLNKHS 705
            |..:..:||. ...:.|....||..|.:|::|.|||...|| ..:|....:..:||..||..|.:
 Worm   518 SKDLTADFKE-KKADMLGQKSVEFNVLVLSSGSWPTFPTTP-ITLPQQLSKTIEIFGQFYNEKFN 580

  Fly   706 GRQLTLQPQMGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTT---RKHILQVSTYQMCVL 767
            ||:||.           |:                  |...|..|:|   :|::...:|.|||.:
 Worm   581 GRRLTW-----------VY------------------SQSRGEITSTAFPKKYVFTATTAQMCTM 616

  Fly   768 LLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKT---KTKDIEPTDEFYVN 829
            ||||.:|..|.:.|...|.:.|:.....:.||.      :.||..:.|   |..::..|....:|
 Worm   617 LLFNEQDSYTVEQIAAATKMDEKSAPAIVGSLI------KNLVLKADTELQKEDEVPMTATVSLN 675

  Fly   830 DAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTS 894
            .|:.:|..||.:.....|.::..:.:..:..|:||||..|.|.||||||.|||:.|..|:::|.:
 Worm   676 KAYMNKKVRVDLSKFTMKQDAVRDTENVQKNVEEDRKSVISACIVRIMKTRKRVQHQQLMTEVIT 740

  Fly   895 QLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934
            ||..||.|....||:.|..|||:||:.|:...:.:|.|||
 Worm   741 QLSGRFKPKVEMIKRCIGSLIEKEYMLRTEGQKDLYEYLA 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	193..832	CDD:459983	179/713 (25%)
		Cullin_Nedd8	864..926	CDD:463146	31/61 (51%)
cul-1	NP_499309.1	Cullin	17..678	CDD:459983	179/713 (25%)
		Cullin_Nedd8	710..772	CDD:463146	31/61 (51%)