DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul3 and cul-1

DIOPT Version :9

Sequence 1:	NP_723909.2	Gene:	Cul3 / 34896	FlyBaseID:	FBgn0261268	Length:	934	Species:	Drosophila melanogaster
Sequence 2:	NP_499309.1	Gene:	cul-1 / 176466	WormBaseID:	WBGene00000836	Length:	780	Species:	Caenorhabditis elegans

Alignment Length:	820	Identity:	222/820 - (27%)
Similarity:	379/820 - (46%)	Gaps:	128/820 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 ETIWASLKNAIQ-EIQKKNNSGLSFEQLYRNAY----NMVLHKH--------------------- 228
            |.:|..|::.:. ..:::|.:...:..||.:.|    ::.|...
Worm    14 EVVWKKLQDGLDVAYRRENMAPKDYMTLYTSVYDYCTSITLSTSRRDGEDGRAESSTPARTAGAD 78

  Fly   229 --GNRLYYGLREVVSEHLEHKVRADVL-------EALHSNFLPKLNQAWTDHQTSMVMIRDILMY 284
              |:.:|        :.:|..|:|.|:       |....:.|......|.:.:.|..::..|..|
Worm    79 FVGHEMY--------QRVEEYVKAYVIAVCEKGAELSGEDLLKYYTTEWENFRISSKVMDGIFAY 135

  Fly   285 MDRVYVQQREVDN-------VYNLGLILFRDQVVRYSEIQKALREKLLGMVMEERHGEAINHLAI 342
            ::|.:: :||:|.       ||.|.|::::..:  :::::..:.:.:|.::..||.|..||...|
Worm   136 LNRHWI-RRELDEGHENIYMVYTLALVVWKRNL--FNDLKDKVIDAMLELIRSERTGSMINSRYI 197

  Fly   343 KNACSMLITLGI-NSRT------------VYEEDFEKPFLAQSAAFYKFESQNFLAE-NNAGVYI 393
            ......|:.||: :|.|            ||:|.||..||..:..||..|:.|||:. .|...|:
Worm   198 SGVVECLVELGVDDSETDAKKDAETKKLAVYKEFFEVKFLEATRGFYTQEAANFLSNGGNVTDYM 262

  Fly   394 KKVEARITEESSRAALYLDKDTEPRIVRVVEEELIKKHMRPIVEMENSGVVYMIKNSKTEDLACT 458
            .|||.|:.:|..|..|||:..|:..:....|..||...: ..::....|   ::.:.:.:||:..
Worm   263 IKVETRLNQEDDRCQLYLNSSTKTPLATCCESVLISNQL-DFLQRHFGG---LLVDKRDDDLSRM 323

  Fly   459 YKLFSRLKEEGLKVIADTMSAYLREQG-RMLVKEEENGNTNPITFVQNLLDLKDRFDQFLVHSFA 522
            :||..|: ..||..:..::..::.::| :.|.:......|:...:|:.||::.:|:...:..||.
Worm   324 FKLCDRV-PNGLDELRKSLENHIAKEGHQALERVAMEAATDAKLYVKTLLEVHERYQSLVNRSFK 387

  Fly   523 NDRIFKNVISSDFEHFLNLN------------NKSPEYLSLFIDDKLKKGGKGMSEQEIESILDK 575
            |:..|...:......|:|.|            .||.|.|:.:.|..|:|..|...|.|:|.:..|
Worm   388 NEPGFMQSLDKAATSFINNNAVTKRAPPQAQLTKSAELLARYCDQLLRKSSKMPDEAELEELQTK 452

  Fly   576 TMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSV 640
            .||:|:::.:||||.::|....:|||:...|.||:.|.|.|:|||:.||.::|::|..|..|..|
Worm   453 IMVVFKYIDDKDVFSKFYTKMFSKRLISELSASDEAEANFITKLKSMCGYEYTARLSKMVNDTQV 517

  Fly   641 SNTIMDEFKNFVNNNNLSLGGVELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFKNFYLNKHS 705
            |..:..:||. ...:.|....||..|.:|::|.|||...|| ..:|....:..:||..||..|.:
Worm   518 SKDLTADFKE-KKADMLGQKSVEFNVLVLSSGSWPTFPTTP-ITLPQQLSKTIEIFGQFYNEKFN 580

  Fly   706 GRQLTLQPQMGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTT---RKHILQVSTYQMCVL 767
            ||:||.           |:                  |...|..|:|   :|::...:|.|||.:
Worm   581 GRRLTW-----------VY------------------SQSRGEITSTAFPKKYVFTATTAQMCTM 616

  Fly   768 LLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKT---KTKDIEPTDEFYVN 829
            ||||.:|..|.:.|...|.:.|:.....:.||.      :.||..:.|   |..::..|....:|
Worm   617 LLFNEQDSYTVEQIAAATKMDEKSAPAIVGSLI------KNLVLKADTELQKEDEVPMTATVSLN 675

  Fly   830 DAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTS 894
            .|:.:|..||.:.....|.::..:.:..:..|:||||..|.|.||||||.|||:.|..|:::|.:
Worm   676 KAYMNKKVRVDLSKFTMKQDAVRDTENVQKNVEEDRKSVISACIVRIMKTRKRVQHQQLMTEVIT 740

  Fly   895 QLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934
            ||..||.|....||:.|..|||:||:.|:...:.:|.|||
Worm   741 QLSGRFKPKVEMIKRCIGSLIEKEYMLRTEGQKDLYEYLA 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	196..831	CDD:279260	178/709 (25%)
		CULLIN	582..724	CDD:214545	48/141 (34%)
		Cullin_Nedd8	866..926	CDD:287520	29/59 (49%)
cul-1	NP_499309.1	Cullin	18..677	CDD:279260	178/711 (25%)
		CULLIN	459..599	CDD:214545	52/170 (31%)
		Cullin_Nedd8	707..774	CDD:214883	33/66 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830