Protein Alignment Cul3 and cul-4

DIOPT Version :10

• Sequence 1: NP_723909.2
• Gene: Cul3 / 34896
• FlyBaseID: FBgn0261268
• Length: 934
• Species: Drosophila melanogaster
• Sequence 2: NP_495525.2
• Gene: cul-4 / 174198
• WormBaseID: WBGene00000839
• Length: 840
• Species: Caenorhabditis elegans
• Alignment Length: 914
• Identity: 250/914 - (27%)
• Similarity: 414/914 - (45%)
• Gaps: 116/914 - (12%)

  Fly    63 MNINVPNASSMQQHQQSQNRLSAQGLASASRRSYHLAASGGRVRADNRINTNHPLTPTPLSMPVP 127
            |....|...|.::.:..|.|.|::..||...     .....::|.|....::..:.....|..:
 Worm     1 MTSGAPPTISTEKSRSKQLRKSSKRTASTVE-----GTEAKQMRGDTENRSDGEMDDVSTSSEI- 59

  Fly   128 APAAPAVVKTETSATTSGPSTSASASAESTEKRFKEIARKYPLWLPEYKRRA--FNASMDEKYVE 190
             ......::...|.|.:...|:|      |.:|.|:     .|.:..:|..|  .:.:|.:..::
 Worm    60 -RHGNGFIENFRSQTGNSSRTTA------TNERIKK-----KLVIKNFKANANQNDVAMGDTNID 112

  Fly   191 TI-------WASLKNAIQEIQKKNNSGLSFEQLYRNAYNMVLHKHGNRLYYGLREVV-------S 241
            :.       ||.|.:.:..|.:...:..:.|.|:....::........||..|..:|       .
 Worm   113 STDGSVGRDWAVLSDNVFAILEDRKTVTTLEGLFSKVRSVCDKNQSKVLYDRLVAIVVQFAKSLK 177

  Fly   242 EHLEHKVRADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYV--QQREVDNVYNLGLI 304
            |.|....:..:.|.....:|.|..|.|..:...:.:||:|.:::||:.:  ...|:..::...:.
 Worm   178 ESLNAVEQVPLAEDNCEQYLEKFGQIWQAYPVKINLIRNIFLHLDRIALGATDTEILPLWECFMQ 242

  Fly   305 LFRDQVVRYSEIQKALR-EKL---LGMVMEERHGEAINHLAIKNACSMLITLGINSRTVYEEDFE 365
            :|  |...:..|.|..: .||   |.|.|::..........:::...||.|:.::      |:|.
 Worm   243 IF--QKTFFPNIFKEFKATKLFNALYMAMQKIMQRYPVDSPLRSLVDMLQTVHVS------EEFA 299

  Fly   366 KPFLAQSAAFYKFESQNFLAENNAGVYIKKVEARITEESSRAALYLDKDTEPRIVRVVEEE---- 426
            |..::|....|..|..:.:.:.|...|::..|.:|...|....:..|   ||..::.|:..
 Worm   300 KFLISQLREHYNNERIDKVPKMNCNDYMEYCEDQINRYSQLVKVNFD---EPSALKDVQATVTNC 361

  Fly   427 LIKKHMRPIVEMENSGVVYMIKNSKTEDLACTYKLFSRLKE--EGLKVIADTMSAYLREQGRMLV 489
            ||::.:..|:..:...   :|.:....|:.   ::|:..::  .|...:....|.||:::|..|:
 Worm   362 LIQQAIPEILTHDFDD---LIDSDNISDIG---RMFNLCRQCVGGEDEVRTQFSKYLKKRGEKLI 420

  Fly   490 ---KEEENGNTNPITFVQNLLDLKDRFDQFLVHSF--ANDRI-FKNVISSDFEHFLNLN-NKSPE 547
               .:|:        .|..||..|.:.|..:..||  |||.: .:..:|..||.|:|.. ::|.|
 Worm   421 ATCPDED--------LVSELLAFKKKVDFIMTGSFKSANDPVKMRQCLSDAFESFVNKQVDRSAE 477

  Fly   548 YLSLFIDDKLKKGGKGMSEQ-EIESILDKTMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDF 611
            .:|......|....|.:|:. .::.::|:.:||||:|..|||||.|||..|||||.|.:|.|.|.
 Worm   478 LISKHFHTLLHSSNKNVSDDTTLDQMVDEAIVLFRYLRGKDVFEAYYKRGLAKRLFLERSASVDA 542

  Fly   612 EKNMISKLKTECGCQFTSKLEGMFKDMSVSNTIMDEFKNFVNNNNLSLGGVELTVRILTTGFWPT 676
            ||.::.|||||||..||.|||||||||..|......|..::.:.|..  ....|.|::|..:|||
 Worm   543 EKMVLCKLKTECGSAFTYKLEGMFKDMDASENYGRLFNQYLEHMNKE--KANFTARVITPEYWPT 605

  Fly   677 QTATPNCNIPAAPREAFDIFKNFYLNKHSGRQLTLQPQMGTAYINAVFYGRKAVESEKDKDAPSS 741
            .. |...|||...|:....:::||..:|..|.:.....:.:|.|:|.|
 Worm   606 YD-TYEINIPKEMRDTLTDYQDFYRVQHGNRNVKWHHGLASAVISASF----------------- 652

  Fly   742 SSSGCGVPTTTRKHILQVSTYQMCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQ 806
             ..||       |..|..:.||..:|||||..:..|..:|.:.|.|.|.|:|:.:.:|..|:...
 Worm   653 -RPGC-------KKELIATMYQTVILLLFNKCETWTVAEIVEHTKILEIEVVKNVLALLGGRDKP 709

  Fly   807 RLLVR----NSKTKTKDIE--PTDEFYVNDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDR 865
            ::|.|    .|:.|...:|  ..::|.||..|..|..||:|..|..|...| |.||.:.:|:.||
 Worm   710 KVLQRVEGGGSEKKEGTVENLKNEKFVVNSKFTEKRCRVRIAQVNIKTAVE-ETKEVKEEVNSDR 773

  Fly   866 KHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVY 930
            :::|:||:||||||||:|.|..|::::..||  ||..|...||||:|.||||||:.|.||:...|
 Worm   774 QYKIDAAVVRIMKARKQLNHQTLMTELLQQL--RFPVSTADIKKRLESLIEREYISRDPEEASSY 836

  Fly   931 NYLA 934
            ||:|
 Worm   837 NYVA 840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	193..832	CDD:459983	177/671 (26%)
		Cullin_Nedd8	864..926	CDD:463146	34/61 (56%)
cul-4	NP_495525.2	Cullin	122..741	CDD:459983	177/671 (26%)
		Cullin_Nedd8	772..832	CDD:463146	34/61 (56%)