Protein Alignment Cul3 and Cul3

DIOPT Version :10

• Sequence 1: NP_723909.2
• Gene: Cul3 / 34896
• FlyBaseID: FBgn0261268
• Length: 934
• Species: Drosophila melanogaster
• Sequence 2: XP_061516687.1
• Gene: Cul3 / 1277848
• VectorBaseID: AGAMI1_007458
• Length: 785
• Species: Anopheles gambiae
• Alignment Length: 764
• Identity: 593/764 - (77%)
• Similarity: 656/764 - (85%)
• Gaps: 17/764 - (2%)

  Fly   183 SMDEKYVETIWASLKNAIQEIQKKNNSGLSFEQLYRNAYNMVLHKHGNRLYYGLREVVSEHLEHK 247
            :|||||||:||:.|||||||||||||||||||:||||||.|||||||.|||.||:|||:.|||.|
Mosquito    27 TMDEKYVESIWSLLKNAIQEIQKKNNSGLSFEELYRNAYTMVLHKHGERLYSGLKEVVTHHLESK 91

  Fly   248 VRADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQQREVDNVYNLGLILFRDQVVR 312
            ||.:||.:.:.|||..|||.|.|||||||||||||||||||||||.:|||||||||.:|||||||
Mosquito    92 VREEVLRSFNCNFLQTLNQCWNDHQTSMVMIRDILMYMDRVYVQQNDVDNVYNLGLNIFRDQVVR 156

  Fly   313 YSEIQKALREKLLGMVMEERHGEAINHLAIKNACSMLITLGINSRTVYEEDFEKPFLAQSAAFYK 377
            |..|:..:||.||.|||.||.||||:|:||||||.||:.||||.|.|||||||:|||.|||||||
Mosquito   157 YPRIRDHMRETLLNMVMCERKGEAIDHIAIKNACQMLMVLGINQRWVYEEDFERPFLTQSAAFYK 221

  Fly   378 FESQNFLAENNAGVYIKKVEARITEESSRAALYLDKDTEPRIVRVVEEELIKKHMRPIVEMENSG 442
            .|||.|||||:|.|||::||||||||:.||.||||:.||.|||.|||:||||||||.||||||||
Mosquito   222 LESQKFLAENSASVYIRRVEARITEEAERAKLYLDESTESRIVEVVEDELIKKHMRTIVEMENSG 286

  Fly   443 VVYMIKNSKTEDLACTYKLFSRLKEEGLKVIADTMSAYLREQGRMLVKEEENGNTNPITFVQNLL 507
            ||||::|:|||||||.:|||||: ..|||.|||.:|..||..||.||||||||:|||||||||||
Mosquito   287 VVYMLQNTKTEDLACMHKLFSRV-SGGLKTIADCVSQNLRSLGRDLVKEEENGSTNPITFVQNLL 350

  Fly   508 DLKDRFDQFLVHSFANDRIFKNVISSDFEHFLNLNNKSPEYLSLFIDDKLKKGGKGMSEQEIESI 572
            |||||.|.||.|||.||:.|||:||||||||||||:|||||||||||||||||.|||||||||:|
Mosquito   351 DLKDRSDHFLYHSFNNDKTFKNMISSDFEHFLNLNSKSPEYLSLFIDDKLKKGCKGMSEQEIETI 415

  Fly   573 LDKTMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKD 637
            |||||||||:|.||||||||||.|||||||||||||||.||||||||||||||||||||||||||
Mosquito   416 LDKTMVLFRYLQEKDVFERYYKAHLAKRLLLNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFKD 480

  Fly   638 MSVSNTIMDEFKNFVNNNNLSLGGVELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFKNFYLN 702
            ||||||:|:||||.:||:|.:|.|||||||||||||||||:.|||||||||||:||:.||.|||.
Mosquito   481 MSVSNTVMEEFKNHINNDNSALEGVELTVRILTTGFWPTQSVTPNCNIPAAPRKAFETFKRFYLA 545

  Fly   703 KHSGRQLTLQPQMGTAYINAVFYGRKAVESEK-----DKDAPSSSSSGCGVPT-------TTRKH 755
            ||||||||||||:||.|:||.|||.|| |.||     ...|||:.||  ..||       ..::|
Mosquito   546 KHSGRQLTLQPQLGTVYMNAEFYGVKA-EKEKTEGNCSSTAPSAGSS--SAPTGGAASLDAPKRH 607

  Fly   756 ILQVSTYQMCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDI 820
            :||:||||||||:|||||:.:||:||.||||||.::|:||||||||||..||||||..|| :|:|
Mosquito   608 VLQLSTYQMCVLMLFNNRERMTYEDIQQETDIPSKDLIRALQSLSMGKQQQRLLVRTPKT-SKEI 671

  Fly   821 EPTDEFYVNDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAH 885
            ..||||||||||.||||:||||||||||||||||||||.|||||||||||||||||||||||:.|
Mosquito   672 VSTDEFYVNDAFVSKFHKVKIQTVAAKGESEPERKETRSKVDEDRKHEIEAAIVRIMKARKRMPH 736

  Fly   886 NLLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934
            ||||||||||||||||||||.||||||||||||||.|:|||||:|.|||
Mosquito   737 NLLVSDVTSQLKSRFLPSPVIIKKRIEGLIEREYLARTPEDRKIYVYLA 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	193..832	CDD:459983	491/650 (76%)
		Cullin_Nedd8	864..926	CDD:463146	56/61 (92%)
Cul3	XP_061516687.1	None