Protein Alignment Cul3 and Cul4

DIOPT Version :10

• Sequence 1: NP_723909.2
• Gene: Cul3 / 34896
• FlyBaseID: FBgn0261268
• Length: 934
• Species: Drosophila melanogaster
• Sequence 2: XP_308149.4
• Gene: Cul4 / 1269506
• VectorBaseID: AGAMI1_009954
• Length: 756
• Species: Anopheles gambiae
• Alignment Length: 815
• Identity: 293/815 - (35%)
• Similarity: 444/815 - (54%)
• Gaps: 83/815 - (10%)

  Fly   128 APAAPAVVKTETSATTSGPSTSASASAESTEKRFKEIARKYPLWLPEYKRRAFNASMDEKYVETI 192
            :|...|::|           |:|:......:|...:..:.||             |:.|.:.||.
Mosquito    17 SPINGAIIK-----------TTATGKPGDVKKIIIKNMKSYP-------------SIPENFEETT 57

  Fly   193 WASLKNAIQEIQKKNNSGLSFEQLYRNAYNMVLHKHGNRLYYGLREVVSEHLEHKVRADVLEALH 257
            |..|:.|:..||.......|.|.|.:...:|...|..::||..|..:|.:|    |:|:::..|.
Mosquito    58 WNQLRKAVIAIQTSTPIEYSLECLCQAVSHMCEDKMDSQLYVNLTALVEQH----VKANIVPFLS 118

  Fly   258 SN-----FLPKLNQAWTDHQTSMVMIRDILMYMDRVYV-QQREVDNVYNLGLILFRDQVVRYSEI 316
            .:     :|.|:|..|..|...|:|||.|.:|:||:|| ....|.:::.:||.||||.:...:.:
Mosquito   119 ESGDKLVYLKKMNDYWQSHCQQMIMIRSIFLYLDRIYVLNNPTVHSIWEMGLELFRDHIAMNNLV 183

  Fly   317 QKALREKLLGMVMEERHGEAINHLAIKNACSMLITLGINSRTVYEEDFEKPFLAQSAAFYKFESQ 381
            |....|.:|.::.:||||:.::...:|:...||..|     .:|.:.||:.||..:...|:.|.|
Mosquito   184 QARTVEGILILIEKERHGDTVDRSLLKSLLRMLSDL-----QIYRDAFEQKFLMATKHLYQAEGQ 243

  Fly   382 NFLAENNAGVYIKKVEARITEESSRAALYLDKDTEPRIVRVVEEELIKKHMRPIVEMENSGVVYM 446
            ..:.|.:...|::.|:.|:.||..|...|||..|..:::..||.:||.:|:..|::   .|:..:
Mosquito   244 AKMEELDVPDYLQHVDKRLNEEEERLEHYLDGCTRHQLIVTVERQLINEHVTGILQ---KGLDQL 305

  Fly   447 IKNSKTEDLACTYKLFSRLKEEGLKVIADTMSAYLREQGRMLVKEEENGNTNPITFVQNLLDLKD 511
            ::.::..||...||||||:| .|...:....:||::::||.:|.:.|...    :.||:|||.||
Mosquito   306 LEENRLSDLTRLYKLFSRVK-NGTTELCAHFNAYIKKKGRTIVIDPEKDK----SMVQDLLDYKD 365

  Fly   512 RFDQFLVHSFANDRIFKNVISSDFEHFLN-LNNKSPEYLSLFIDDKLKKGGKGMSEQEIESILDK 575
            :.|..:...|..:..|.|.:...||:|:| .:||..|.::.::|.||:.|.|..:|:|:|.||||
Mosquito   366 KMDNIVNTCFERNEKFGNSLREAFEYFINQRSNKPAELIAKYVDMKLRAGNKEATEEELEQILDK 430

  Fly   576 TMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSV 640
            .||.|||:..|||||.:||..||||||:.||.|.|.||:|:||||.|||..||||||||||||.:
Mosquito   431 IMVQFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKQECGGGFTSKLEGMFKDMEL 495

  Fly   641 SNTIMDEFK-NFVNNNNLSLGGVELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFKNFYLNKH 704
            |..|...|| :..|:.:..|..::|||.|||.|||||.... ...:|....:...||..|||.||
Mosquito   496 SRDINFAFKQSMQNSEHKELQNIDLTVNILTMGFWPTYPVM-EVTLPQELLQYQSIFNKFYLAKH 559

  Fly   705 SGRQLTLQPQMGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTYQMCVLLL 769
            |||:|..||.:|...:.|.|            ||....              ||||.:|..||||
Mosquito   560 SGRKLQWQPTLGHCVLKAQF------------DAGPKD--------------LQVSLFQALVLLL 598

  Fly   770 FNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVNDAFNS 834
            ||....:|:::|....:|...||.|.||||:.||  .|:|.:  ..|.:::|.||:|..|:.|.:
Mosquito   599 FNYNAAITFEEIRAAVNIENGELKRTLQSLACGK--ARVLTK--IPKGREVENTDKFQFNNEFTN 659

  Fly   835 KFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSR 899
            |..|:||..:..| |:..|:|.|..:|.:||:::|:||||||||.||.|:||||::::..||  .
Mosquito   660 KLFRIKINQIQMK-ETTEEQKATEERVYQDRQYQIDAAIVRIMKMRKTLSHNLLITELYKQL--T 721

  Fly   900 FLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934
            |...|..:|||||.||:|:|::|..:::..|||:|
Mosquito   722 FPVKPADLKKRIESLIDRDYMERDKDNQNQYNYVA 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	193..832	CDD:459983	234/646 (36%)
		Cullin_Nedd8	864..926	CDD:463146	32/61 (52%)
Cul4	XP_308149.4	Cullin	58..657	CDD:459983	234/646 (36%)
		Cullin_Nedd8	688..748	CDD:463146	32/61 (52%)