DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul3 and cul4b

DIOPT Version :9

Sequence 1:	NP_723909.2	Gene:	Cul3 / 34896	FlyBaseID:	FBgn0261268	Length:	934	Species:	Drosophila melanogaster
Sequence 2:	XP_017951653.1	Gene:	cul4b / 100151714	XenbaseID:	XB-GENE-963628	Length:	865	Species:	Xenopus tropicalis

Alignment Length:	900	Identity:	308/900 - (34%)
Similarity:	486/900 - (54%)	Gaps:	103/900 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 SAQGLASASRRSYHLAASGGRVRADNRINTN-------HPLTPTPLSMPVPAPAAPAVVKTETSA 141
            |.|||::.:..:..:...|.......|:|.:       .||:| |.:....:......::.|.:.
Frog    20 SKQGLSTPNPPAQEVRTEGNSTSKKRRLNISSSDKDDLDPLSP-PRNSSSSSNHIQKKLRFEDTL 83

  Fly   142 TTSG---------PSTSASASAESTEKRFKEI-----------------------ARKYP----- 169
            ...|         ||:|.|:|:.....|.|.:                       |...|
Frog    84 DFLGLDVKMAEESPSSSCSSSSTPQAVRSKNLLISPVGVGHHANGLTKASPVSSFANSKPGSAKK 148

  Fly   170 LWLPEYKRRAFNASMDEKYVETIWASLKNAIQEIQKKNNSGLSFEQLYRNAYNMVLHKHGNRLYY 234
            |.:..:|.:   ..:.|.|.:..|..||.|::.||...:...:.|:||:...|:..:|....||.
Frog   149 LVIKNFKDK---PKLPENYTDETWQKLKGAVEAIQNSTSIKYNLEELYQAVENLCSYKISANLYK 210

  Fly   235 GLREVVSEHLE---HKVRADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQQRE-V 295
            .||::..:|::   |:.|.|.|:::  .||.|:::.|.||...|:|||.|.:::||.||.|.. :
Frog   211 QLRQICEDHIKAQIHQFREDALDSV--LFLKKIDKCWQDHCRQMIMIRSIFLFLDRTYVLQNSML 273

  Fly   296 DNVYNLGLILFRDQVVRYSEIQKALREKLLGMVMEERHGEAINHLAIKNACSMLITLGINSRTVY 360
            .:::::||.|||:.::...::|....:.:|.::..||:||||:...:::..|||..|     .:|
Frog   274 PSIWDMGLELFRNHIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDL-----QIY 333

  Fly   361 EEDFEKPFLAQSAAFYKFESQNFLAENNAGVYIKKVEARITEESSRAALYLDKDTEPRIVRVVEE 425
            ::.||:.||.::...|..|.|..:.|.....|:..|..|:.||:.|...|||:.|:..::..||:
Frog   334 QDSFEQRFLEETNRLYAAEGQRLMQEREVPEYLHHVNKRLEEEADRVITYLDQSTQKPLIATVEK 398

  Fly   426 ELIKKHMRPIVEMENSGVVYMIKNSKTEDLACTYKLFSRLKEEGLKVIADTMSAYLREQGRMLVK 490
            :|:.:|:...::   .|:.:::..::.:||:..|:||||:: .|::|:......|::..|..:|.
Frog   399 QLLGEHLTATLQ---KGLNHLLDENRIQDLSLLYQLFSRVR-GGVQVLLQHWIEYIKAFGSTIVI 459

  Fly   491 EEENGNTNPITFVQNLLDLKDRFDQFLVHSFANDRIFKNVISSDFEHFLNLN-NKSPEYLSLFID 554
            ..|...    |.||.|||.||:.|..:...|..:..|.|.:...||.|:|.. ||..|.::.::|
Frog   460 NPEKDK----TMVQELLDFKDKVDHVIDVCFLKNEKFVNAMKEAFETFINKRPNKPAELIAKYVD 520

  Fly   555 DKLKKGGKGMSEQEIESILDKTMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKL 619
            .||:.|.|..:::|:|.:|||.|::|||:..|||||.:||..||||||:.||.|.|.||:|:|||
Frog   521 SKLRTGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKL 585

  Fly   620 KTECGCQFTSKLEGMFKDMSVSNTIMDEFKNFVNNNNLSLGGVELTVRILTTGFWPTQTATPNCN 684
            |.|||..||||||||||||.:|..||..||.::.|.|:. |.:||||.|||.|:|||.... ..:
Frog   586 KHECGAAFTSKLEGMFKDMELSKDIMVHFKQYMQNQNVP-GNIELTVNILTMGYWPTYVPM-EVH 648

  Fly   685 IPAAPREAFDIFKNFYLNKHSGRQLTLQPQMGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVP 749
            :|....:..:|||.|||.|||||:|..|..:|...:.|.|.     |.:|:
Frog   649 LPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGQCVLKAEFN-----EGKKE-------------- 694

  Fly   750 TTTRKHILQVSTYQMCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSK 814
                   ||||.:|..|||:||..|..:.::|.|.|.|.:.||.|.||||:.|:  .|:||::
Frog   695 -------LQVSLFQTLVLLMFNEGDEFSLEEIRQATGIEDSELRRTLQSLACGR--ARVLVKS-- 748

  Fly   815 TKTKDIEPTDEFYVNDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKA 879
            .|:||::..|:|..||.|..:..|::|..:..| |:..|:..|..:|.:||:::|:||||||||.
Frog   749 PKSKDVDDGDKFTFNDDFRHQLFRIRINQIQMK-ETVEEQASTTERVFQDRQYQIDAAIVRIMKM 812

  Fly   880 RKRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934
            ||.|:||||||:|.:|||  |...|..:|||||.||:|:|::|..|:...|||:|
Frog   813 RKTLSHNLLVSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYVA 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul3	NP_723909.2	Cullin	196..831	CDD:279260	231/639 (36%)
		CULLIN	582..724	CDD:214545	75/141 (53%)
		Cullin_Nedd8	866..926	CDD:287520	34/59 (58%)
cul4b	XP_017951653.1	Cullin	169..766	CDD:366357	233/643 (36%)
cul4b	XP_017951653.1	Cullin_Nedd8	794..859	CDD:214883	38/66 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0000491
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.930