DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pol32 and Pold3

DIOPT Version :9

Sequence 1:NP_001188816.1 Gene:Pol32 / 34892 FlyBaseID:FBgn0283467 Length:431 Species:Drosophila melanogaster
Sequence 2:NP_001355309.1 Gene:Pold3 / 67967 MGIID:1915217 Length:462 Species:Mus musculus


Alignment Length:496 Identity:117/496 - (23%)
Similarity:195/496 - (39%) Gaps:114/496 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 LDDCMIDFDRCVLVTDLLEEYK-LSY------KEVNDVLEAYI---KEQEPATKFEKRFLVHGKR 61
            :|:.:.|.::.|       .|| |||      .:...:|..|:   :::....:....:||.|..
Mouse    10 IDEFVTDQNKIV-------TYKWLSYTLGVHVNQAKQMLYEYVERKRKENSGAQLHVTYLVSGSL 67

  Fly    62 KTQGSDSGEDLYSVVLESRMQDWLAKVQ-DAESQLYSVKIAGGTKAPAAIFKPMQHLEVKLAKVE 125
            ...|....:  .:||.|.:::...:|:. .|...:||::     ||......|:.:.:..:.| .
Mouse    68 IQNGHSCHK--VAVVREDKLEAVKSKLAVTASIHVYSIQ-----KAMLKDSGPLFNTDYDILK-S 124

  Fly   126 QRPGAGKI--------VPSANGTTPHNGVKSEPTKSEPSKSAVKLEPSKSSLKSE----PA-KSK 177
            ......|.        ||.|...:|.:      .|.|.|......|...|.|.:.    || |..
Mouse   125 NLQNCSKFSAIQCAAAVPRAPAESPSS------RKYEQSNLQAASEAQASELTTNGHGPPASKQA 183

  Fly   178 AEKP----------VASKSSPEDKKTSPKEQ----ASKAKPAAAKKGSI-NSFFTAAASKPKDVK 227
            :::|          .|:|:...:|:|.|:.:    ||.|...|..|||: ::||..||.....| 
Mouse   184 SQQPKGIMGMLISKAATKTQDTNKETKPEAREVTSASSAGGKAPGKGSVMSNFFGKAAMNKLKV- 247

  Fly   228 ATPSKSTSGTVDNFFKKQPAGAKKS---PPESEDKSKKDASNSNKKEASKKKSPSPT--KKPTTA 287
                        |...:|....:|:   ||.|..:.|..|..:.|| :|:|..|...  |:.::.
Mouse   248 ------------NLDSEQAVKEEKTVEQPPVSVTEPKLAAPPAQKK-SSRKSEPGKVQQKEKSSR 299

  Fly   288 NTSMQLFDEESAESSDEEEKLDMLRRKVIESDNDSDQ--------EKASSSKRRRISDSED---- 340
            ...:.|.|||:.|:  |..|....|.|:.:||:..|:        .:|.|.....:|...|    
Mouse   300 GKRVDLSDEEAKET--EHLKKKRRRIKLPQSDSSEDEVFEDSPEMYEADSPSPPPVSPPPDPMPK 362

  Fly   341 EEQPPKKSADEETIALDEKMDTEPANETYLDEDGFVITQR-----------KPTKAQPANKKVSP 394
            .|.||.|.:..||   ..:......::|::||:|.::|::           :..|.:||:....|
Mouse   363 TEPPPVKRSSGET---KRRRKRVLKSKTFVDEEGCIVTEKVYESESCTDSEEELKMKPASAHKPP 424

  Fly   395 KAAA---PVNKKKSPPSAAKA-GKDAPKTKQAGIMNFFSKK 431
            .||.   |..::|.|...|.| ||   ..:|..|..||.||
Mouse   425 AAAVKREPREERKGPKKGAAALGK---ANRQVSITGFFQKK 462

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pol32NP_001188816.1 CDC27 <153..431 CDD:370537 84/329 (26%)
Pold3NP_001355309.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 144..186 11/47 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 200..230 8/29 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 254..384 34/135 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 403..462 17/61 (28%)
PIP-box. /evidence=ECO:0000250|UniProtKB:Q15054 452..459 2/6 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_28HEU
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.