Protein Alignment PolD3 and POLD3

DIOPT Version :10

• Sequence 1: NP_609743.1
• Gene: PolD3 / 34892
• FlyBaseID: FBgn0283467
• Length: 431
• Species: Drosophila melanogaster
• Sequence 2: NP_006582.1
• Gene: POLD3 / 10714
• HGNCID: 20932
• Length: 466
• Species: Homo sapiens
• Alignment Length: 500
• Identity: 108/500 - (21%)
• Similarity: 177/500 - (35%)
• Gaps: 118/500 - (23%)

  Fly     7 LDDCMIDFDRCVLVTDLLEEYK-LSY------KEVNDVLEAYI---KEQEPATKFEKRFLVHGKR 61
            :|:.:.|.::.|       .|| |||      .:...:|..|:   :::....:....:||.|..
Human    10 IDEFVTDQNKIV-------TYKWLSYTLGVHVNQAKQMLYDYVERKRKENSGAQLHVTYLVSGSL 67

  Fly    62 KTQGSDSGEDLYSVVLESRMQDWLAKVQ-DAESQLYSVKIAGGTKAPAAIFKPMQHLEVKLAKVE 125
            ...|....:  .:||.|.:::...:|:. .|...:||::     ||......|:.:.:..:.| .
Human    68 IQNGHSCHK--VAVVREDKLEAVKSKLAVTASIHVYSIQ-----KAMLKDSGPLFNTDYDILK-S 124

  Fly   126 QRPGAGKI--------VPSANGTTPHNGVKSEPTKSEPSKSAVKLEPSKSSLKSE-----PAKSK 177
            ......|.        ||.|              .:|.|.|:.|.|.|...:.||     ...:.
Human   125 NLQNCSKFSAIQCAAAVPRA--------------PAESSSSSKKFEQSHLHMSSETQANNELTTN 175

  Fly   178 AEKPVASKSSPEDKKTSPKEQASKAKPAAAKKGSINSFFTAAASKPKDVKATPSKS--TSGTVDN 240
            ...|.|||...:..|......|||   ||||....|......|.:..:..|..:|:  ....:.|
Human   176 GHGPPASKQVSQQPKGIMGMFASK---AAAKTQETNKETKTEAKEVTNASAAGNKAPGKGNMMSN 237

  Fly   241 FFKKQPAGAKKSPPESEDKSKKD---------------ASNSNKKEASKKKSP-SPTKKPTTANT 289
            ||.|......|...:||...|::               |:.:..|::|||..| ...:|......
Human   238 FFGKAAMNKFKVNLDSEQAVKEEKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKKRGK 302

  Fly   290 SMQLFDEESAESSDEEEKLDMLRRKVIESDNDSDQEKASSSKRRRISDSEDEEQPPKKSADEETI 354
            .:.|.|:|:.|:.:..:|  ..|.|:.|||:..|:....|.   ...::|....||..|...|.:
Human   303 RVALSDDETKETENMRKK--RRRIKLPESDSSEDEVFPDSP---GAYEAESPSPPPPPSPPLEPV 362

  Fly   355 ALDEKMDTEP------------------ANETYLDEDGFVITQRK------PTKAQPANKKVSPK 395
               .|.:.||                  .::||||.:|.::|::.      ....:..|.|.|..
Human   363 ---PKTEPEPPSVKSSSGENKRKRKRVLKSKTYLDGEGCIVTEKVYESESCTDSEEELNMKTSSV 424

  Fly   396 AAAPVNKKKSPPSAAKAGKDAPK---------TKQAGIMNFFSKK 431
            ...|....|..|...:.|   ||         .:|..|..||.:|
Human   425 HRPPAMTVKKEPREERKG---PKKGTAALGKANRQVSITGFFQRK 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolD3	NP_609743.1	CDC27	<153..431	CDD:462819	78/333 (23%)
POLD3	NP_006582.1	CDC27	19..466	CDD:462819	105/489 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	169..188		4/18 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	199..232		9/35 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	274..393		28/126 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	406..466		13/62 (21%)
		PIP-box. /evidence=ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:22148433	456..463		2/6 (33%)