DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dao and smyd4

DIOPT Version :9

Sequence 1:	NP_001260462.1	Gene:	dao / 34891	FlyBaseID:	FBgn0028862	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	XP_012812690.1	Gene:	smyd4 / 779741	XenbaseID:	XB-GENE-945037	Length:	777	Species:	Xenopus tropicalis

Alignment Length:	865	Identity:	193/865 - (22%)
Similarity:	315/865 - (36%)	Gaps:	234/865 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 LLITPVQR-----QKLSRNLEDGDLEASTSAAPLSR------PENGEEDDDLIGAVGGLGISSPT 133
            |:..|||.     |.:..:|...:.|..:|.|.|..      ....::::.||..:    ..:.|
Frog    38 LMEHPVQEWQDQAQSIWAHLTSSEKEKFSSIADLDEIFQACLSHLQQDEEQLIERL----CCNVT 98

  Fly   134 TTKEPVLDFRPHVLKWFQHLRHQTGHFKSEEESRRLREAGNDSYRKERHPLKASDLFTEAIFLAP 198
            ..|:      |:.:::|                   :|.||..:.:::: ..|:.|:::||..|.
Frog    99 VAKD------PNAVQFF-------------------KEEGNKRFAEKQY-ATAAGLYSKAISHAK 137

  Fly   199 ARNTLAAALAHANRSLVLFDCGLYAESYDDCLCALDLGYPEEYLPLIKLRQAACALKLRNFALCE 263
            : .:.|.|:..||||..||..|.|:...:|...|.|.||||.....|..|:|.|..:||..:.|:
Frog   138 S-GSEALAVCFANRSAALFYLGQYSVCLEDIQHAQDHGYPERLRNKILQRKAECFQRLRKPSSCD 201

  Fly   264 EHLHELLHIELNQVFEARTHELWHQCEVLKVERFEMAVQTGDDLDINDSKAFEIAWLDNSSSLH- 327
            ..|..:..::..:..:..|       |.||    |||:.....: .|.|.|..:.: |.....|
Frog   202 PKLECVETVKPKKEPQTST-------ERLK----EMALDRNPHI-TNASCALHLNF-DTRKGRHL 253

  Fly   328 -TTRAVAKNALIFESEAVA--MVPSGN--------------C-RVCDYCGITQFIPFPCIYCSNR 374
             .::.:.:..::...||.|  ::|...              | ..|.||........||.|||
Frog   254 LASQNIEQGEVLIWEEAFASVIIPERKQWRKEIKWDTRITACDHYCHYCLNRVIASLPCQYCS-- 316

  Fly   375 LVVYCSRQCRFK-HAAIHAVECFGHQIELFESFGEV---FGMPRLLQLAFR-MLITGLPELLGHC 434
            ...|||::|..| ..:.|.:||         |.|::   .||  ....|.| :|:.|       |
Frog   317 FARYCSQECMDKAWRSYHYIEC---------SMGDLLLALGM--FCHTALRAVLVAG-------C 363

  Fly   435 RK-KPTLSKLWSA----------INGGLQERQDIAYSAVLRLERLKEERPTDTVIALALAAHILS 488
            |. ..:|.:..||          ......|:...:|.:|:.|....|..|.:......|.|  .:
Frog   364 RLFSQSLEQTGSADATDKTKVCNSKNTYHEKYCSSYQSVVNLLPHTENHPAERKFLCGLTA--AA 426

  Fly   489 IYLSKC-------TTFFDQLEKSLPTASRMSSAEWELLCAAL---LMRHIGQL--RHRSLTACRS 541
            :|...|       .:...|.|||| |....:..:|..:...|   ::||:.||  ..:::||.:.
Frog   427 LYKKLCLIMAKDLVSSTSQTEKSL-TKESGTIEDWSSVRQFLGPTVLRHMLQLYCNAQAVTALQE 490

  Fly   542 FVLPADPHVFSPLNEFQLWAAPMRLQEGHLHLLAGEVAV-VSYSVYPDTLNLCRHSCSSTICAKF 605
                         ||          .|..|.|:....:: ::.:|:| .|:|..|||.......|
Frog   491 -------------NE----------DESSLSLVKSNKSIRLATAVFP-VLSLLNHSCDPNTTVSF 531

  Fly   606 SGRTVTALALLDLPAGSGIYNCFAGGNFQQLPREERTKQLLESG--IRCHCNACQLTHSDDQFHK 668
            :||.||..|...:.....:.:|: |.:..::...|| :|||:..  ..|.|.||.   .:.:..|
Frog   532 TGRFVTVRANRPIRRDEEVTHCY-GPHKLRMDVAER-QQLLKDQYFFVCQCKACT---EELKGKK 591

  Fly   669 FHRYRCDNPNCMEIFTPNALPHAPSLRWWLSEEYTQPEFNGADLIMC--PHCGEYQKLEWFWAFT 731
            .|.:.|  |.|                        :.:..|.:.:.|  ..|          .:|
Frog   592 THGFFC--PLC------------------------KAQLEGEEALYCTGARC----------TYT 620

  Fly   732 TSLIDCELIEERCKLYAAIERAENQLMDLH---------------ECKVALARLLLEQCLMVHRE 781
            .|  ..:|.....:|...|:.|:.||.|..               ||.::...|||.: :|.|..
Frog   621 AS--QTQLTSRLNQLGNHIQIAKVQLQDNKTDNAKMTLMSCLSEAECFLSQDHLLLGE-IMDHLA 682

  Fly   782 GATVLD-DWEFNKLGSILRSVLPSVMAQYGGQSIEYVK--------YFSYFW--DVM-------- 827
            .|...| :|:  .....||..:..|...||..|:|...        .|:.|.  |.|
Frog   683 QAEASDGNWK--AAAGHLRKSISIVKVHYGSSSMELGHELFKLAQILFNGFEVPDAMRTIMEAQK 745

  Fly   828 ALSNYKCNDRELMQMLNALE 847
            .||.:...|..|:|.|..:|
Frog   746 VLSMHYGPDHNLVQELKTME 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dao	NP_001260462.1	TPR_11	165..235	CDD:290150	20/69 (29%)
		TPR repeat	200..235	CDD:276809	12/34 (35%)
		TPR repeat	243..270	CDD:276809	8/26 (31%)
		zf-MYND	355..395	CDD:280009	14/40 (35%)
smyd4	XP_012812690.1	TPR repeat	106..134	CDD:276809	7/47 (15%)
		TPR_11	107..170	CDD:290150	20/83 (24%)
		TPR repeat	143..173	CDD:276809	11/29 (38%)
		zf-MYND	299..338	CDD:280009	14/40 (35%)
		SET	<509..555	CDD:279228	14/47 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1278034at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46165
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020