DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dao and Zmynd15

DIOPT Version :9

Sequence 1:	NP_001260462.1	Gene:	dao / 34891	FlyBaseID:	FBgn0028862	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_001025100.1	Gene:	Zmynd15 / 574428	MGIID:	3603821	Length:	736	Species:	Mus musculus

Alignment Length:	423	Identity:	82/423 - (19%)
Similarity:	116/423 - (27%)	Gaps:	158/423 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SAAVS-GSGATSAAATASAPPAVTLSELIGQQLKHLNADELLHKDELQLLLLITPVQRQKLSR-- 92
            |..:| |.||.....     |.:..|.|:|.:                     .|:..:.||.
Mouse    66 SVGISLGQGAEPGPG-----PGLGASRLLGDE---------------------PPLHLRDLSPYV 104

  Fly    93 ---NLEDGDLEASTSAAPLSRPENG--EEDDDLIGAVGGLGISSPTTTKEPVLDFRPHVLKWFQH 152
               :||||              |.|  ||:|:..|...|:....|....||.    |...::.|.
Mouse   105 SFVSLEDG--------------EEGEEEEEDEEHGERPGMEKVEPQEGGEPA----PPSKRFPQE 151

  Fly   153 LRHQTGHFKSEEESRRLREAGNDSYRKERHPLKASDLFTEAIFLAPARNTLAAALAHANRSLVLF 217
            .:.......:::|:.|...:..:....||.|.|...          .:|..||.| |       .
Mouse   152 AKPAPESEVTQQEASREEGSREERPEDERAPEKRKG----------QKNAEAAPL-H-------L 198

  Fly   218 DCGLYAESYDDCLCALDL---------GY--------PEEYLPLIKLRQAACAL------KLRNF 259
            .|.|........:..:||         |.        |..|..|  ....||.:      |.|..
Mouse   199 SCLLLVTDEHGTILGIDLLMDGAQGSVGQNPGTENLAPRAYALL--CHSMACPMGSGDPRKPRQL 261

  Fly   260 ALCEEHLHELLHIELNQVFEARTHELWHQCEVLKVERFEMAVQTGDDLDINDSKAFEIAWLDNSS 324
            .:.:.|||               .||......|.|:..:..::|.     .....|..|.|
Mouse   262 TVGDAHLH---------------RELESLVPRLGVKLAKTPMRTW-----GPRPGFTFASL---- 302

  Fly   325 SLHTTRAVAKNALIFESEAVAMVPSGNCRVCDYCGITQFIP--FPCIYCSNRLVVYCSRQC---- 383
                                      ..|.|..|....|..  .||..||  .|:||...|
Mouse   303 --------------------------RARTCHVCHKHSFEVKLTPCPQCS--AVLYCGEACLQAD 339

  Fly   384 --RFKHAAIHAVECFGHQIELF-ESFGEVFGMP 413
              |......|...|  .::..| |..||:..:|
Mouse   340 WRRCPDDVSHRFWC--PRLSAFMERVGELASLP 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dao	NP_001260462.1	TPR_11	165..235	CDD:290150	13/69 (19%)
		TPR repeat	200..235	CDD:276809	7/34 (21%)
		TPR repeat	243..270	CDD:276809	8/32 (25%)
		zf-MYND	355..395	CDD:280009	13/47 (28%)
Zmynd15	NP_001025100.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	70..94		8/49 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..192		23/110 (21%)
		zf-MYND	307..353	CDD:280009	13/47 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	556..583
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	696..736
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838890
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830