DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dao and smyd1b

DIOPT Version :9

Sequence 1:	NP_001260462.1	Gene:	dao / 34891	FlyBaseID:	FBgn0028862	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_001034725.1	Gene:	smyd1b / 569027	ZFINID:	ZDB-GENE-060522-1	Length:	486	Species:	Danio rerio

Alignment Length:	528	Identity:	96/528 - (18%)
Similarity:	169/528 - (32%)	Gaps:	185/528 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 FKSEEESRRLREAGNDSYRKERHPLKASD-LFTEAIFLAPARNTLAAALAHA--NRSLVLFDCG- 220
            |.|..:.|.|| |..:::        |.| ||.|..|.:...::.|:::.|:  .|...|..||
Zfish     7 FDSPGKGRGLR-ATKEAW--------AGDVLFAEPPFASVVFDSQASSICHSCFRRQEKLQRCGQ 62

  Fly   221 -LYAESYD-------------DCLCALDLGYPEEYLPLIKLRQAACAL-------------KLRN 258
             .:|:..|             :|......|.|    |...:|.||..|             :|..
Zfish    63 CRFAQYCDKTCQRAGWEEHKLECAAIKTYGKP----PSENVRLAARILWRMDKQGSVVSDNQLTT 123

  Fly   259 FALCEEHLHELLHIELNQVFEARTH---ELW-------------HQCEVLKVERFEMAVQTGDDL 307
            ....|:|:.::...:|.. |:...|   :.|             |...|:....|.::.|.|  |
Zfish   124 LEDLEDHICDISEDDLKD-FKVDIHNFLDYWPRNSKPHTVDSVSHILGVINCNGFMVSDQRG--L 185

  Fly   308 DINDSKAFEIAWLDNSSSLHTTRAVAKNA------LIFESE------AVAMVPSG---NCRVCDY 357
            .......|....|.|.........:..|.      .:|.|:      |:..:.:|   .....||
Zfish   186 QAVGVGLFPNLCLVNHDCWPNCTVILNNGNQSAIDTVFHSQKRIELRALGKISAGEEVTVAYVDY 250

  Fly   358 CGIT----------QFIPFPCIYCSNRLVVYCSRQCRFKHAAIHAVECFGHQIELFESFGEVFGM 412
            ..::          .|....|.:|:.::    ....:...|.:..|:....|::
Zfish   251 LNVSADRQRLLKQQYFFDCTCKHCTEKI----KDDLKMAGAEVDGVKVPEEQVK----------- 300

  Fly   413 PRLLQLAFRMLITGLPELLGHCRKKPTLSKLWSAINGGLQERQDIAYSAVLRLERLKEERPTDTV 477
                            |:....|:|  |.|:..|       |.:..|:.|:::.|...|: .:.|
Zfish   301 ----------------EVTEFSRQK--LEKMEKA-------RIEANYNEVVKICRECVEK-QENV 339

  Fly   478 IALALAAHILSIYLSKCTT---------FFDQ------------LEKSLPTASRMSSA------- 514
            :|   ..||  .||..|.|         |||:            |:...|..:::..|
Zfish   340 LA---DTHI--YYLRVCCTLSEVLSYLQFFDEASEYARKMVDGYLKLYHPNNAQLGMATMRAGVT 399

  Fly   515 EWE---------LLC---AALLMRH---------IGQLRHRSLTACRSFVLPADPHVFSPLNEFQ 558
            .|:         ::|   |.|::.|         :..:|.::....|.|  ..:.:|:..:.|..
Zfish   400 HWQAGFIEVAHGMICKAFAILMITHGPTHPITKDLEAMRMQTEMELRMF--QQNEYVYHSMREAA 462

  Fly   559 LWAAPMRL 566
            |...|||:
Zfish   463 LKNQPMRM 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dao	NP_001260462.1	TPR_11	165..235	CDD:290150	19/87 (22%)
		TPR repeat	200..235	CDD:276809	9/51 (18%)
		TPR repeat	243..270	CDD:276809	8/39 (21%)
		zf-MYND	355..395	CDD:280009	7/49 (14%)
smyd1b	NP_001034725.1	zf-MYND	47..85	CDD:280009	7/37 (19%)
smyd1b	NP_001034725.1	SET	<173..247	CDD:214614	12/75 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582773
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740