DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dao and Smyd4-2

DIOPT Version :9

Sequence 1:	NP_001260462.1	Gene:	dao / 34891	FlyBaseID:	FBgn0028862	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_648574.1	Gene:	Smyd4-2 / 39414	FlyBaseID:	FBgn0036282	Length:	663	Species:	Drosophila melanogaster

Alignment Length:	731	Identity:	153/731 - (20%)
Similarity:	244/731 - (33%)	Gaps:	229/731 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 LGISSPTTTKEPVLDFRPHVLKWFQH---------------LRHQTGHFKSEEESRRLREAGNDS 176
            |.|.|.....:|||....||...|:.               |...:|....||....|::|
  Fly    55 LSIFSDREVCDPVLGVLEHVQPVFKQKDALFSAQRRAQADKLYLMSGSGDGEESRELLQQA---- 115

  Fly   177 YRKERHPLKASDLFTEAIFLAPARNT-------LAAALAHANRSLVLFDCGLYAESYDDCLCALD 234
                   |.|::|   |:..||.||.       |..|||:.:|:.:|...|....:.:|...|::
  Fly   116 -------LMAANL---AVMRAPDRNADPVLDEGLTLALAYRSRASILIRLGEGEAALNDLKLAIN 170

  Fly   235 LGYP-----EEYLPLIKL-------RQAACALKL---------RNFALCEEHL-------HELLH 271
            .|..     :.||.:.|.       .:|..:||:         .:.|||.:.|       .|...
  Fly   171 FGLELKSSVDYYLKMAKAYAVMGEPARAEISLKIAEKMPGCDATHIALCRKELSSVKPKPKEATS 235

  Fly   272 IELNQVFEARTHELWHQCEVLKVERFEMAVQTGDDLDINDSKAFEIAWLDNSSSLHTTRAVAKNA 336
            .::.|:....:.||....:|:::            ::..|...|.:|    :..|.|     .:.
  Fly   236 EQVPQLAHGESAELVGASKVVRL------------VETKDKGRFVVA----NEGLRT-----GDV 279

  Fly   337 LIFESE-AVAMVPSGNCRVCDYCGITQFIPFPCIYCSNRLVVYCSRQCRFKH-AAIHAVECFGHQ 399
            |:||.. |..:.||.....|.:|......|..|::||.  :.:||.||..:. ::.|..||  ..
  Fly   280 LLFEEPVAACLEPSYFGTHCHHCFKRLHTPVSCLHCSG--IAFCSAQCMGEACSSYHRFEC--EY 340

  Fly   400 IELFESFGEVFGMPRLLQLAFRMLITGLPELLGHCRKKPTLSKLWSAINGGLQERQDIAYSAVLR 464
            ::|.  .|.  ||..|..:|.| :.|..|.|                       .|.:| :|.|.
  Fly   341 MDLM--IGS--GMSILCFIALR-IFTQAPSL-----------------------EQGLA-TANLL 376

  Fly   465 LERL---KEERPTDTVIALALAAHILSIYLSKCTTFFDQLEKSL-PTASRMSSAEWELLCAALLM 525
            .|.|   :|:|..|..:..||.:..|...|.|...|..:..:.: |||.       ||..|..|:
  Fly   377 FEHLCSHEEDRQPDDYLRRALMSGFLLRILQKSLYFGRRKTEGVNPTAV-------ELQVATALL 434

  Fly   526 RHIGQLRHRSLTACRSFVLPADPHVFSPLNEFQLWAAPMRLQEGH-------LHLLAGEVAVVSY 583
            ..:..|::                     |..|::..  ::.|.|       ::|.||.....||
  Fly   435 GLLQVLQY---------------------NAHQIYQT--QVTEEHRFDGSKTVYLAAGLYGTGSY 476

  Fly   584 SVYPDTLNLCRHSCSSTICAKFSGRTVTALALLDLPAGSGI---YN-CFAGGNFQQLPREERTKQ 644
                     ..|.|..:....|.|:.:...|.....|...:   |. .|...|.::..|..|.:.
  Fly   477 ---------FNHECWPSTACHFVGKKLVLTATRPHRANELVAVNYGPIFIKNNLKERQRSLRGRY 532

  Fly   645 LLESGIRCHCNACQ-----LTHSDDQFHKFHRYRCDNPNCMEIFTPNALPHAPSLRWWLSEEYTQ 704
                ...|.|.|||     |...|.|.    |:.|.:.||     .|.|.....|
  Fly   533 ----SFSCSCMACQENWPLLQKLDKQV----RFWCTSANC-----SNLLKFPKDL---------- 574

  Fly   705 PEFNGADLIMCPHC----------GEYQKLEWFWAFTTSLIDCELIEERCKLY----------AA 749
                 |..:.||.|          .:..|:|..:......::.:...|..:|:          ||
  Fly   575 -----AKDVRCPRCRKNISLKESVAKMIKIEELYREAARAMEAQKTVEAIELFKESLDMFFQVAA 634

  Fly   750 IERAENQL--MDLHEC 763
            :...:..:  ..||:|
  Fly   635 LPHKDTIVAQQSLHKC 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dao	NP_001260462.1	TPR_11	165..235	CDD:290150	19/76 (25%)
		TPR repeat	200..235	CDD:276809	11/41 (27%)
		TPR repeat	243..270	CDD:276809	9/49 (18%)
		zf-MYND	355..395	CDD:280009	11/40 (28%)
Smyd4-2	NP_648574.1	TPR_11	142..205	CDD:290150	15/62 (24%)
		zf-MYND	299..338	CDD:280009	11/40 (28%)
		SET	<474..513	CDD:279228	8/47 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452063
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1278034at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR46165
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850